Patents by Inventor Jorgen Berntsen
Jorgen Berntsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11942220Abstract: A method of processing a series of images of an embryo to determine estimated timings of developmental events for the embryo, wherein the method comprises: determining feature information for each image, the feature information for each image representing the content of the image; establishing machine learned classifiers for associating each image with a respective likelihood of the image being associated with one or more developmental events based on the feature information for the image; applying the machine learned classifiers to the feature information for each image to determine a respective likelihood of the image being associated with one or more developmental events, and determining estimated timings for the plurality of developmental events for the embryo from the respective likelihoods of the respective images being associated with respective ones of the plurality of developmental events. The method may further comprise determining an indication of a confidence estimate for the timings.Type: GrantFiled: May 29, 2019Date of Patent: March 26, 2024Assignee: VITROLIFE A/SInventors: Jens Rimestad, Jørgen Berntsen, Michael Sass Hansen, Sebastian Gerrit Jan Brandes Kraaijenzank
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Patent number: 11124764Abstract: Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a sample platform comprising a plurality of receptacles for holding embryos within the incubation chamber for incubation. The sample platform may comprise a slide carrier on which embryo slides containing the receptacles may be placed incubation. The sample platform is rotatable about a rotation axis relative to the incubation chamber housing so as to allow receptacles to be selectively rotated to a monitoring position that is aligned with a viewing port provided in the incubation chamber housing, for example an opening or window. An imaging device is located outside the incubation chamber and arranged to image embryos within the incubation chamber at the monitoring position through the viewing port.Type: GrantFiled: January 13, 2015Date of Patent: September 21, 2021Assignee: UNISENSE FERTILITECH A/SInventors: Niels Ramsing, Jonas Lerche Hansen, Kim Bondergaard Madsen, Troels Kofoed Mejer, Jorgen Berntsen
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Publication number: 20210249135Abstract: A method of processing a series of images of an embryo to determine estimated timings of developmental events for the embryo, wherein the method comprises: determining feature information for each image, the feature information for each image representing the content of the image; establishing machine learned classifiers for associating each image with a respective likelihood of the image being associated with one or more developmental events based on the feature information for the image; applying the machine learned classifiers to the feature information for each image to determine a respective likelihood of the image being associated with one or more developmental events, and determining estimated timings for the plurality of developmental events for the embryo from the respective likelihoods of the respective images being associated with respective ones of the plurality of developmental events. The method may further comprise determining an indication of a confidence estimate for the timings.Type: ApplicationFiled: May 29, 2019Publication date: August 12, 2021Applicant: VITROLIFE A/SInventors: Jens RIMESTAD, Jørgen BERNTSEN, Michael Sass HANSEN, Sebastian Gerrit Jan Brandes KRAAIJENZANK
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Patent number: 10844342Abstract: Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a slide carrier comprising a plurality of compartment walls that define compartments for holding embryo slides within the incubation chamber for incubation. The slide carrier is moveable, for example by rotation, relative to the incubation chamber housing to allow a selected compartment to be moved to a loading position defined at least in part by a loading port wall associated with the incubation chamber housing. The loading port wall is arranged to cooperate with the wall of a compartment in the loading position to restrict the extent to which the environment of the compartment in the loading position is in fluid communication with the environments of other compartments in the incubation chamber.Type: GrantFiled: January 13, 2015Date of Patent: November 24, 2020Assignee: UNISENSE FERTILITECH A/SInventors: Niels Ramsing, Kim Bondergaard Madsen, Jonas Lerche Hansen, Troels Kofoed Mejer, Jorgen Berntsen
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Patent number: 10282842Abstract: Apparatus and methods for helping a user establish values (e.g. timings) for a plurality of parameters of interest (e.g. cell divisions) relating to the development of an embryo from a series of images of the embryo are described. For each parameter of interest an image is selected for display to a user seeking to establish a value for the parameter of interest. For example, the selected image may be an image predicted to be an image reflecting the value for the parameter of interest. For example, the selected image may be based on a calculated timing for a particular developmental event. The timing may be calculated from a numerical analysis of the images or maybe predetermined. If the user is unable to determine a value for the parameter of interest from the selected image, the user may scroll through neighboring images until the user can determine a value for the parameter of interest.Type: GrantFiled: February 12, 2015Date of Patent: May 7, 2019Assignee: UNISENSE FERTILITECH A/SInventors: Anton Paarup Kylling, Jorgen Berntsen, Niels Ramsing, Soren Porsgaard, Tine Qvistgaard Kajhoj, Reidun Berghold Kuhlmann
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Patent number: 9588104Abstract: The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.Type: GrantFiled: November 12, 2013Date of Patent: March 7, 2017Assignee: Unisense FertiliTech A/SInventors: Niels B. Ramsing, Jorgen Berntsen, Jens K. Gundersen, Holger Soe Plougsgaard
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Publication number: 20170009202Abstract: Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a sample platform comprising a plurality of receptacles for holding embryos within the incubation chamber for incubation. The sample platform may comprise a slide carrier on which embryo slides containing the receptacles may be placed incubation. The sample platform is rotatable about a rotation axis relative to the incubation chamber housing so as to allow receptacles to be selectively rotated to a monitoring position that is aligned with a viewing port provided in the incubation chamber housing, for example an opening or window. An imaging device is located outside the incubation chamber and arranged to image embryos within the incubation chamber at the monitoring position through the viewing port.Type: ApplicationFiled: January 13, 2015Publication date: January 12, 2017Applicant: UNISENSE FERTILITECH A/SInventors: Niels Ramsing, Jonas Lerche Hansen, Kim Bondergaard Madsen, Troels Kofoed Mejer, Jorgen Berntsen
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Publication number: 20170009195Abstract: Apparatus and methods for monitoring embryos in an incubator are described. The apparatus comprises an incubation chamber defined by an incubation chamber housing and a slide carrier comprising a plurality of compartment walls that define compartments for holding embryo slides within the incubation chamber for incubation. The slide carrier is moveable, for example by rotation, relative to the incubation chamber housing to allow a selected compartment to be moved to a loading position defined at least in part by a loading port wall associated with the incubation chamber housing. The loading port wall is arranged to cooperate with the wall of a compartment in the loading position to restrict the extent to which the environment of the compartment in the loading position is in fluid communication with the environments of other compartments in the incubation chamber.Type: ApplicationFiled: January 13, 2015Publication date: January 12, 2017Applicant: UNISENSE FERTILITECH A/SInventors: Niels Ramsing, Kim Bondergaard Madsen, Jonas Lerche Hansen, Troels Kofoed Mejer, Jorgen Berntsen
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Publication number: 20160379364Abstract: Apparatus and methods for helping a user establish values (e.g. timings) for a plurality of parameters of interest (e.g. cell divisions) relating to the development of an embryo from a series of images of the embryo are described. For each parameter of interest an image is selected for display to a user seeking to establish a value for the parameter of interest. For example, the selected image may be an image predicted to be an image reflecting the value for the parameter of interest. For example, the selected image may be based on a calculated timing for a particular developmental event. The timing may be calculated from a numerical analysis of the images or maybe predetermined. If the user is unable to determine a value for the parameter of interest from the selected image, the user may scroll through neighbouring images until the user can determine a value for the parameter of interest.Type: ApplicationFiled: February 12, 2015Publication date: December 29, 2016Applicant: Unisense FertiliTech A/SInventors: Anton Paarup Kylling, Jorgen Berntsen, Niels Ramsing, Soren Porsgaard, Tine Qvistgaard Kajhoj, Reidun Berghold Kuhlmann
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Publication number: 20140212911Abstract: The present invention relates to a system arranged for assisting secure handling of cells in order to minimize the risk of handling mistakes resulting in mix-up of cell samples. The system allows for one to one identification of cells during a whole culturing period. This is obtained by providing a culturing system with loading/exit control means which ensures that only one device is capable of being loaded/removed at a time.Type: ApplicationFiled: March 31, 2014Publication date: July 31, 2014Applicant: UNISENSE FERTILITECH A/SInventors: Niels B. Ramsing, Jorgen Berntsen, Jens K. Gundersen, Holger Soe Plougsgaard
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Publication number: 20140141463Abstract: The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.Type: ApplicationFiled: November 12, 2013Publication date: May 22, 2014Applicant: UNISENSE FERTILITECH A/SInventors: Niels B. Ramsing, Jorgen Berntsen, Jens K. Gundersen, Holger Soe Plougsgaard
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Publication number: 20140128667Abstract: The present invention relates to a system and a method for determining quality criteria in order to select the most viable embryos after in vitro fertilization. The present invention may further be applied for iteratively adapting embryo quality criteria based on new knowledge, historical selection & fertilization data and cooperation between fertility clinics.Type: ApplicationFiled: June 29, 2012Publication date: May 8, 2014Applicant: UNISENSE FERTILITECH A/SInventors: Niels B Ramsing, Jens K Gundersen, Karen Marie Hilligsøe, Jørgen Berntsen, Inge Errebo Agerholm
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Patent number: 8633017Abstract: The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.Type: GrantFiled: June 27, 2008Date of Patent: January 21, 2014Assignee: Unisense FertiliTech A/SInventors: Niels B. Ramsing, Jorgen Berntsen, Jens K. Gundersen, Holger Soe Plougsgaard
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Publication number: 20130102837Abstract: The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and/or ii) determining the extent and/or spatial distribution of cellular or organelle movement during the cell division period; and/or iii) determining duration of an inter-division period; and/or iv) determining the extent and/or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.Type: ApplicationFiled: July 31, 2012Publication date: April 25, 2013Applicant: Unisense FertiliTech A/SInventors: Niels B. Ramsing, Jorgen Berntsen
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Publication number: 20120309043Abstract: The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and/or ii) determining the extent and/or spatial distribution of cellular or organelle movement during the cell division period; and/or iii) determining duration of an inter-division period; and/or iv) determining the extent and/or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.Type: ApplicationFiled: January 31, 2012Publication date: December 6, 2012Applicant: Unisense FertiliTech A/SInventors: Niels B. Ramsing, Jorgen Berntsen
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Patent number: 8265357Abstract: The present invention relates to a method and a system for determination of a change in a cell population, as well as a method for using said method and system for estimating a quality measure of embryos and for selecting embryos for in vitro fertilization, said method comprising the steps of sequentially acquiring at least two images of the cell population, comparing at least a part of the at least two images obtaining at least one difference image, computing a parameter from the at least one difference image, based on said computed parameter determining whether a change has occurred.Type: GrantFiled: October 16, 2006Date of Patent: September 11, 2012Assignee: Unisense FertiliTech A/SInventors: Niels B. Ramsing, Jorgen Berntsen
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Publication number: 20110165609Abstract: The present invention relates to a device, a system and a method for performing monitoring and/or cultivation of microscopic objects. Microscopic objects are in particular microscopic organisms like bacteria and cell cultures, such as cultivation objects like tissue samples and embryos, providing optimal and safe cultivation conditions for incubation during embryo development and for facilitating the selection of optimal embryos to be used in in vitro fertilization (IVF) by facilitating embryo handling for automated digital imaging and time-lapse microscopy.Type: ApplicationFiled: June 27, 2008Publication date: July 7, 2011Inventors: Niels B. Ramsing, Jorgen Berntsen, Jen K. Gunmark, Holger Soe Plougsgaard
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Publication number: 20100041090Abstract: The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and/or ii) determining the extent and/or spatial distribution of cellular or organelle movement during the cell division period; and/or iii) determining duration of an inter-division period; and/or iv) determining the extent and/or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.Type: ApplicationFiled: June 15, 2007Publication date: February 18, 2010Applicant: Unisense FertiliTech A/SInventors: Niels B. Ramsing, Jorgen Berntsen
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Publication number: 20080247628Abstract: The present invention relates to a method and a system for determination of a change in a cell population, as well as a method for using said method and system for estimating a quality measure of embryos and for selecting embryos for in vitro fertilisation, said method comprising the steps of sequentially acquiring at least two images of the cell population, comparing at least a part of the at least two images obtaining at least one difference image, computing a parameter from the at least one difference image, based on said computed parameter determining whether a change has occurred.Type: ApplicationFiled: October 16, 2006Publication date: October 9, 2008Applicant: Unisense FertiliTech A/SInventors: Niels B. Ramsing, Jorgen Berntsen