Abstract: The present invention relates to a microneedle patch composition comprising one or more microneedles each comprising: (a) a tapered tip portion containing a therapeutically active ingredient dispersed in a matrix of a biodegradable polymer capable of providing sustained release of the therapeutically active ingredient over a period of at least two days after insertion of the microneedle or microneedles into the skin, and (b) a fast dissolving microneedle backing layer portion containing a water-soluble polymer overlayering the tip portion, said microneedle or microneedles being attached to and extending from an adhesive surface of a removable substrate.

Abstract: A trigonal cutting insert for a shoulder milling tool includes an upper side, an opposite lower side and a peripheral side surface. A plurality of indexable cutting edges extend along corners of the cutting insert, each cutting edge having a main cutting edge, a corner cutting edge, and a surface-wiping secondary cutting edge. The upper side includes a recessed central surface, and a plurality of positively inclined rake surfaces having a main rake surface portion, a corner rake surface portion, and a secondary rake surface portion. A concave indentation is formed in the corner rake surface portion and in at least an initial part of the main rake surface portion adjacent to the corner rake surface portion, wherein the concave indentation has an elongated shape.

Abstract: A cutting insert and a shoulder milling tool are disclosed. The cutting insert includes a surface-wiping secondary cutting edge inclined in relation to a median plane of the cutting insert such that a distance to the median plane decreases in a direction toward a corner cutting edge. The corner cutting edge, as seen in a side view along the median plane and towards a main cutting edge, has a concave curve.

Abstract: A cutting insert and a shoulder milling tool are disclosed. The cutting insert includes a surface-wiping secondary cutting edge inclined in relation to a median plane of the cutting insert, such that a distance to the median plane decreases in a direction toward a corner cutting edge. A circumferential surface includes a clearance surface extending along a main cutting edge. The clearance surface along the main cutting edge extends at an acute angle to the median plane, such that the clearance surface forms a negative nominal clearance angle, and wherein the circumferential surface includes first and second abutment surfaces configured for abutment against axial and/or radial support surfaces of the milling tool, the abutment surfaces extending along at least part of the main cutting edge and the surface-wiping secondary cutting edge.

Abstract: A cutting insert for a shoulder milling tool has a trigonal shape and includes a first surface, a second surface, and a circumferential surface extending between the first surface and the second surface. The circumferential surface includes a countersunk circumferential waist portion. The circumferential surface has a first and a second clearance surface extending along a first and a second main cutting edge. Each of the first and second clearance surfaces forma a negative nominal clearance angle. Each of the first and second main cutting edges is arranged inside the countersunk circumferential waist portion, as seen in the view towards the first and second surfaces, respectively.

Abstract: A cutting insert and a shoulder milling tool are disclosed. The cutting insert includes a surface-wiping secondary cutting edge inclined in relation to a median plane of the cutting insert, such that a distance to the median plane decreases in a direction toward a corner cutting edge. A circumferential surface includes a clearance surface extending along a main cutting edge. The clearance surface along the main cutting edge extends at an acute angle to the median plane, such that the clearance surface forms a negative nominal clearance angle, and wherein the circumferential surface includes first and second abutment surfaces configured for abutment against axial and/or radial support surfaces of the milling tool, the abutment surfaces extending along at least part of the main cutting edge and the surface-wiping secondary cutting edge.

Abstract: A trigonal cutting insert for a shoulder milling tool includes an upper side, an opposite lower side and a peripheral side surface. A plurality of indexable cutting edges extend along corners of the cutting insert, each cutting edge having a main cutting edge, a corner cutting edge, and a surface-wiping secondary cutting edge. The upper side includes a recessed central surface, and a plurality of positively inclined rake surfaces having a main rake surface portion, a corner rake surface portion, and a secondary rake surface portion. A concave indentation is formed in the corner rake surface portion and in at least an initial part of the main rake surface portion adjacent to the corner rake surface portion, wherein the concave indentation has an elongated shape.

Abstract: A cutting insert for a shoulder milling tool has a trigonal shape and includes a first surface, a second surface, and a circumferential surface extending between the first surface and the second surface. The circumferential surface includes a countersunk circumferential waist portion. The circumferential surface has a first and a second clearance surface extending along a first and a second main cutting edge. Each of the first and second clearance surfaces forma a negative nominal clearance angle. Each of the first and second main cutting edges is arranged inside the countersunk circumferential waist portion, as seen in the view towards the first and second surfaces, respectively.

Abstract: A cutting insert and a shoulder milling tool are disclosed. The cutting insert includes a surface-wiping secondary cutting edge inclined in relation to a median plane of the cutting insert such that a distance to the median plane decreases in a direction toward a corner cutting edge. The corner cutting edge, as seen in a side view along the median plane and towards a main cutting edge, has a concave curve.

Abstract: The present invention relates to a microneedle patch composition comprising one or more microneedles each comprising: (a) a tapered tip portion containing a therapeutically active ingredient dispersed in a matrix of a biodegradable polymer capable of providing sustained release of the therapeutically active ingredient over a period of at least two days after insertion of the microneedle or microneedles into the skin, and (b) a fast dissolving microneedle backing layer portion containing a water-soluble polymer overlayering the tip portion, said microneedle or microneedles being attached to and extending from an adhesive surface of a removable substrate.

Abstract: A milling insert having an upper side, an under side, a clearance face disposed between the upper and under side, and at least one cutting edge that includes two main edges, which converge toward a nose edge. The cutting edge is formed between two ground part surfaces situated on both sides of a cutting edge line, by on one hand, a primary clearance surface, which is included in the clearance face and is off-plane from a lower, secondary clearance surface, and, on the other hand, a peripheral chip surface, which is included in the upper side and situated on a higher level than a land disposed inside, and which is narrower than the primary clearance surface and has a width of at least 0.3 mm. The milling insert may advantageously be used in milling tools for gear hobbing.

Abstract: A film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a volatile solvent, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent. The composition is capable of forming, after application on skin and evaporation of the solvent, a continuous phase comprising the film-forming polymer and the plasticizer and a dispersed phase comprising droplets of the oily release-enhancing agent.

Abstract: A sprayable film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethylether, and a mixture of dimethyl ether, diethylether and methylethyl ether, and a second propellant selected from C3-5 alkanes, hydrofluoroalkanes, hydrochloroalkanes, fluoroalkanes and chlorofluoroalkanes, the propellant being present in an amount of 50-99.5% w/w of the composition, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent.

Abstract: A film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a volatile solvent, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent. The composition is capable of forming, after application on skin and evaporation of the solvent, a continuous phase comprising the film-forming polymer and the plasticizer and a dispersed phase comprising droplets of the oily release-enhancing agent.

Abstract: A sprayable film-forming pharmaceutical composition for dermal application comprises at least one therapeutically active ingredient dissolved in a pharmaceutically acceptable propellant selected from the group consisting of dimethyl ether, diethyl ether and methylethylether, and a mixture of dimethyl ether, diethylether and methylethyl ether, and a second propellant selected from C3-5 alkanes, hydrofluoroalkanes, hydrochloroalkanes, fluoroalkanes and chlorofluoroalkanes, the propellant being present in an amount of 50-99.5% w/w of the composition, the composition further comprising a film-forming polymer, a plasticizer and an oily release-enhancing agent.

Abstract: A milling insert having an upper side, an under side, a clearance face disposed between the upper and under side, and at least one cutting edge that includes two main edges, which converge toward a nose edge. The cutting edge is formed between two ground part surfaces situated on both sides of a cutting edge line, by on one hand, a primary clearance surface, which is included in the clearance face and is off-plane from a lower, secondary clearance surface, and, on the other hand, a peripheral chip surface, which is included in the upper side and situated on a higher level than a land disposed inside, and which is narrower than the primary clearance surface and has a width of at least 0.3 mm. The milling insert may advantageously be used in milling tools for gear hobbing.

Abstract: A device for grasping and handling generally cylinder sector shaped articles such as pieces of cake or the like, comprises two blade parts (1, 2) and a grip (8, 9) located at one end of these blades. The two blade parts (1, 2) are pivotably connected with each other by means of a hinge (4) located at that end of the blade parts which is opposite to the grip (8, 9).