Patents by Inventor Jorn Gorlach
Jorn Gorlach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020142319Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: August 7, 2001Publication date: October 3, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy R. Hargiss, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia
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Publication number: 20020106712Abstract: The present inventors have discovered that pyruvate orthophosphate dikinase (PPDK) is essential for plant growth. Specifically, the inhibition PPDK gene expression in plant seedlings results in significant developmental abnormalities, including abnormal cotyledon development, abnormal or aborted primary leaf development and significantly reduced growth. Thus, PPDK can be used as a target for the identification of herbicides. Accordingly, the present invention provides methods for the identification of compounds that inhibit PPDK expression or activity, comprising: contacting a compound with a PPDK and detecting the presence and/or absence of binding between said compound and said a PPDK, or detecting a decrease in PPDK expression or activity. The methods of the invention are useful for the identification of herbicides.Type: ApplicationFiled: December 11, 2000Publication date: August 8, 2002Inventors: Andreas S. Kloti, Robert A. Ascenzi, Neil E. Hoffman, Keith R. Davis, Adel Zayed, Jorn Gorlach, Douglas C. Boyes, Jeffrey P. Woessner, Carol M. Hamilton, Maja C. Kricker
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Publication number: 20020081667Abstract: A self-amplifying, transcriptional activation system is described.Type: ApplicationFiled: December 6, 2000Publication date: June 27, 2002Inventors: Jorn Gorlach, Kurt Boudonck
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Publication number: 20020062014Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: May 23, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020059663Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: May 16, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Patent number: 6383787Abstract: Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.Type: GrantFiled: May 10, 2000Date of Patent: May 7, 2002Assignee: Novartis AGInventors: Thomas Schupp, James Madison Ligon, Istvan Molnar, Ross Zirkle, Devon Dawn Cyr, Jörn Görlach
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Publication number: 20020040490Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: April 4, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020040489Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: April 4, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Patent number: 6358719Abstract: Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.Type: GrantFiled: May 10, 2000Date of Patent: March 19, 2002Assignee: Novartis AGInventors: Thomas Schupp, James Madison Ligon, Istvan Molnar, Ross Zirkle, Devon Dawn Cyr, Jörn Görlach
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Patent number: 6355457Abstract: Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.Type: GrantFiled: May 10, 2000Date of Patent: March 12, 2002Assignee: Novartis AGInventors: Thomas Schupp, James Madison Ligon, Istvan Molnar, Ross Zirkle, Devon Dawn Cyr, Jörn Görlach
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Patent number: 6355459Abstract: Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.Type: GrantFiled: May 10, 2000Date of Patent: March 12, 2002Assignee: Novartis AGInventors: Thomas Schupp, James Madison Ligon, Istvan Molnar, Ross Zirkle, Devon Dawn Cyr, Jörn Görlach
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Patent number: 6355458Abstract: Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.Type: GrantFiled: May 10, 2000Date of Patent: March 12, 2002Assignee: Novartis AGInventors: Thomas Schupp, James Madison Ligon, Istvan Molnar, Ross Zirkle, Devon Dawn Cyr, Jörn Görlach
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Publication number: 20020023281Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: February 21, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Publication number: 20020023280Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: February 21, 2002Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Patent number: 6346404Abstract: Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.Type: GrantFiled: May 10, 2000Date of Patent: February 12, 2002Assignee: Novartis AGInventors: Thomas Schupp, James Madison Ligon, Istvan Molnar, Ross Zirkle, Devon Dawn Cyr, Jörn Görlach
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Publication number: 20020004939Abstract: Morphological markers are used in a method of visually identifying plants transformed with a nucleotide sequence (e.g., a heterologous gene). The nucleotide sequence is transformed into a plant that exhibits an abnormal phenotype for a morphological marker. If the transformation of the plant is successful, the progeny of the transformed plant will exhibit a normal phenotype. In a preferred embodiment, the plant is Arabidopsis and the morphological marker is Gl1, which is associated with trichome production on plant leaves. The method is also useful for identifying plants that are homozygous for the transformed gene, and for identifying transformants in the T2 generation that are true crosses, rather than self-crosses.Type: ApplicationFiled: April 11, 2001Publication date: January 10, 2002Inventors: Douglas C. Boyes, Carol M. Hamilton, Andreas Kloti, Jorn Gorlach, Neil Hoffman
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Publication number: 20010044940Abstract: Isolated nucleotide compositions and sequences are provided for Arabidopsis thaliana genes. The nucleic acid compositions find use in identifying homologous or related genes; in producing compositions that modulate the expression or function of its encoded protein, mapping functional regions of the protein; and in studying associated physiological pathways. The genetic sequences may also be used for the genetic manipulation of cells, particularly of plant cells. The encoded gene products and modified organisms are useful for screening of biologically active agents, e.g. fungicides, insecticides, etc.; for elucidating biochemical pathways; and the like.Type: ApplicationFiled: January 26, 2001Publication date: November 22, 2001Inventors: Jorn Gorlach, Yong-Qiang An, Carol M. Hamilton, Jennifer L. Price, Tracy M. Raines, Yang Yu, Joshua G. Rameaka, Amy Page, Abraham V. Mathew, Brooke L. Ledford, Jeffrey P. Woessner, William David Haas, Carlos A. Garcia, Maja Kricker, Ted Slater, Keith R. Davis, Keith Allen, Neil Hoffman, Patrick Hurban
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Patent number: 6121029Abstract: Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.Type: GrantFiled: June 17, 1999Date of Patent: September 19, 2000Assignee: Novartis AGInventors: Thomas Schupp, James Madison Ligon, Istvan Molnar, Ross Zirkle, Devon Dawn Cyr, Jorn Gorlach