Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salt thereof, stereoisomers, tautomers as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A method for monitoring battery cells of a primary on-board electrical system battery of a motor vehicle by galvanostatic impedance spectroscopy is provided. An AC signal having alternating currents of different frequencies is impressed onto the battery cells as an excitation signal, cell voltage signals of the battery cells are detected as frequency-dependent response signals to the excitation signal, impedance spectra of the battery cells are determined depending on the excitation signal and the response signals, and the primary on-board electrical system battery is divided into at least two subsections each having at least one battery cell in order to provide the excitation signal. The primary on-board electrical system battery is electrically connected to a secondary on-board electrical system battery of the motor vehicle.

Abstract: Various systems and methods are provided for a biased cathode assembly of an X-ray tube with improved thermal management and a method of manufacturing same. In one example, a cathode assembly of an X-ray tube comprises an emitter assembly including an emitter coupled to an emitter support structure, and an electrode assembly including an electrode stack and a plurality of bias electrodes. The emitter assembly including a plurality of independent components that are coupled together. The electrode assembly including a plurality of independent components that are coupled together, and the emitter assembly being coupled to the electrode assembly.

Abstract: An energy storage module, particularly a solid state battery, an energy storage system, a vehicle and a method for measuring an electrical voltage on an energy storage module or on an energy storage system is based on two stacked and series-connected energy storage cells, each have an anode layer and a cathode layer. A contact, which is electrically connected to an anode layer located within the stack of a first energy storage cell and to a cathode layer located within the stack of a second energy storage cell, which is adjacent to the first energy storage cell, leads out of the stack such that at least one contact can be contacted from outside the stack.

Abstract: The instant disclosure provides biomarkers and methods for identifying subjects at risk of developing cytokine release syndrome (CRS), neurotoxicity, or both after adoptive immunotherapy to guide preemptive intervention, modified therapy, or the like. For example, adverse event biomarkers may be measured in a subject before pre-conditioning chemotherapy, before immunotherapy (e.g., adoptive immunotherapy infusion comprising a chimeric antigen receptor (CAR)-modified T cell), or shortly after pre-conditioning chemotherapy and/or immunotherapy. Exemplary biomarkers include temperature, cytokine levels and endothelial activation biomarkers, such as angiopoietin-2, von Willebrand factor (vWF), ratio of angiopoietin-2 to angiopoietin-1, and ratio of ADAMTS13 to vWF. Also provided are methods of treating subjects identified as at risk of developing cytokine release syndrome (CRS), neurotoxicity, or both to minimize such potential adverse events.

Abstract: Various systems and methods are provided for a biased cathode assembly of an X-ray tube with improved thermal management and a method of manufacturing same. In one example, a cathode assembly of an X-ray tube comprises an emitter assembly including an emitter coupled to an emitter support structure, and an electrode assembly including an electrode stack and a plurality of bias electrodes. The emitter assembly including a plurality of independent components that are coupled together. The electrode assembly including a plurality of independent components that are coupled together, and the emitter assembly being coupled to the electrode assembly.

Abstract: A device for securing at least one insulating tube on a duct, includes an inner ring configured to be mounted on the duct, an outer ring coaxial to the inner ring, and a transverse web linking the inner and outer rings, the inner and outer rings and the transverse web forming two recesses, arranged on either side of the transverse web, each configured to receive an end of an insulating tube.

Abstract: The present invention is a method for obtaining a ceramic slurry for the production of filaments for 3D FDM printing, comprising adding a polysaccharide, a glycol or an ethanolamine as a gelling agent to a suspension of ceramic material in order to produce said ceramic slurry. The invention also comprises the green body obtained from said slurry and the ceramic filament extruded from the green body.

Abstract: A method for monitoring battery cells of a primary on-board electrical system battery of a motor vehicle by galvanostatic impedance spectroscopy is provided. An AC signal having alternating currents of different frequencies is impressed onto the battery cells as an excitation signal, cell voltage signals of the battery cells are detected as frequency-dependent response signals to the excitation signal, impedance spectra of the battery cells are determined depending on the excitation signal and the response signals, and the primary on-board electrical system battery is divided into at least two subsections each having at least one battery cell in order to provide the excitation signal. The primary on-board electrical system battery is electrically connected to a secondary on-board electrical system battery of the motor vehicle.

Abstract: A method for congestion control in a data communication protocol employing acknowledged communication may include measuring a flight size. A transmission rate may be measured. A trend of the flight size may be determined. A trend of the transmission rate may be determined, and the trend may be derived from a transmission rate gradient calculation, in which either the transmission rate measurements or the transmission rate gradient calculations or both may be filtered to reduce their temporal variability. Whether there is a congestion may be detected according to the determined trend of the transmission rate and the trend of the flight size. Upon detection of the congestion, a change may be made from a current congestion control state to a new congestion control state. Data may be transmitted while respecting a maximum amount of unacknowledged data which the transmitting node may transmit. An apparatus is also disclosed.

Abstract: A pre-coated metallic substrate wherein a bare metallic substrate having a reflectance higher or equal to 60% at all wavelengths between 0.5 and 5.0 ?m is coated with a pre-coating including at least one titanate and at least one nanoparticle; a method for the manufacture of this pre-coated metallic substrate; a method for the manufacture of a coated metallic substrate and a coated metallic substrate.

Abstract: A high-voltage battery for a motor vehicle includes at least one battery module including a cell block with stacked battery cells, wherein the battery cells are embodied as solid-body cells, the internal resistance of which decreases as the temperature rises, a battery housing having a receiving space for receiving the at least one battery module, and a heat-insulating holding device for holding the at least one battery module in the receiving space. The heat-insulating holding device is designed to minimize heat exchange between the at least one battery module and the battery housing for preventing cooling of the battery cells. A motor vehicle with the high-voltage battery is also provided.

Abstract: A system for secure processor virtualization including a secure initialization memory and one or more processors coupled to the secure initialization memory is disclosed. The secure initialization memory includes initialization instructions for launching a security runtime environment before operating systems and cryptographic keying for security handoffs. The processors are configured to retrieve the initialization instructions from the secure initialization memory at startup, execute the initialization instructions to launch the security runtime environment and retrieve at least a portion of the cryptographic keying, and generate specific keying for chip-level resources the processors by combining instruction sets of the chip-level resources and the cryptographic keying.

Abstract: The instant disclosure provides biomarkers and methods for identifying subjects at risk of developing cytokine release syndrome (CRS), neurotoxicity, or both after adoptive immunotherapy to guide preemptive intervention, modified therapy, or the like. For example, adverse event biomarkers may be measured in a subject before pre-conditioning chemotherapy, before immunotherapy (e.g., adoptive immunotherapy infusion comprising a chimeric antigen receptor (CAR) modified T cell), or shortly after pre-conditioning chemotherapy and/or immunotherapy. Exemplary biomarkers include temperature, cytokine levels and endothelial activation biomarkers, such as angiopoietin 2, von Willebrand factor (vWF), ratio of angiopoietin 2 to angiopoietin 1, and ratio of ADAMTS13 to vWF. Also provided are methods of treating subjects identified as at risk of developing cytokine release syndrome (CRS), neurotoxicity, or both to minimize such potential adverse events.

Abstract: The present invention relates to 1,2,3-triazoles of formula: useful for improving or restoring the intracellular calcium homeostasis and RyR-calstabin binding function in human and animal cells. The present invention also relates to methods for synthesizing said compounds, to pharmaceutical compositions containing them, and to the use thereof for preventing or treating skeletal muscle, heart and nervous system disorders.

Abstract: A system for an at least partially electrically driven or hybrid vehicle includes an electronic devices that is configured to supply current to at least one of the further electrical loads on the vehicle, from a number of series-connected energy storage cells in the electrical energy storage which is smaller than the maximum number of series-connected energy storage cells in the energy storage, in the event that a maximum current for the at least one further electrical load exceeds the maximum current which can be delivered by the voltage converter. The vehicle has an electrical energy storage, which is provided for driving the vehicle and comprises energy storage cells connected in series, and a voltage converter coupled to the energy storage for the supply of at least one further electrical load on the vehicle.

Abstract: A securing device includes at least one rigid ring configured to encircle the pipe, and at least one securing system, rigid and distinct from the ring, including a body which has a first contact face configured to be pressed firmly against and secured to a surface of a structure, and at least one groove in which the ring is housed, the groove being configured to allow the securing system to slide with respect to the ring in a direction of sliding along the ring, while being immobile or near-immobile relative to the ring in a plane perpendicular to the direction of sliding.

Abstract: A system that allows a user to access a secured area by confirming location of the user near the secured area and receipt of an access word by the system. A user in possession of a mobile device may be detected at the entrance to a secured location. The system can select a question asking for a passcode corresponding to certain access to the secured location. The question can be spoken to a user through a loudspeaker at the secured location. The user's spoken response can be processed by the system, for example using keyword spotting, to determine if the proper access word is included. If it is, the system can grant access to the secured area.

Abstract: A method for congestion control in a data communication protocol employing acknowledged communication may include measuring a flight size. A transmission rate may be measured. A trend of the flight size may be determined. A trend of the transmission rate may be determined, and the trend may be derived from a transmission rate gradient calculation, in which either the transmission rate measurements or the transmission rate gradient calculations or both may be filtered to reduce their temporal variability. Whether there is a congestion may be detected according to the determined trend of the transmission rate and the trend of the flight size. Upon detection of the congestion, a change may be made from a current congestion control state to a new congestion control state. Data may be transmitted while respecting a maximum amount of unacknowledged data which the transmitting node may transmit. An apparatus is also disclosed.