Abstract: The present disclosure provides complexes comprising: i) a cationic oligosaccharide comprising one or more cationic moieties bonded to a trehalose, a sucrose, or a gluco-n-oligosaccharide moiety, where n is 2-6; ii) a surfactant; and iii) one or more additives selected from: a sterol, a helper lipid, an immunomodulator, and a targeting molecule; and uses thereof.

Abstract: The present disclosure provides complexes comprising a cationic oligosaccharide and an RNA, wherein the cationic oligosaccharide comprises a plurality of cationic moieties bonded to a trehalose, a sucrose, or a gluco-n-oligosaccharide moiety, where n is 2-6, and a ratio of N/P in the complex is less than 20:1

Abstract: Various systems and methods are provided for a biased cathode assembly of an X-ray tube with improved thermal management and a method of manufacturing same. In one example, a cathode assembly of an X-ray tube comprises an emitter assembly including an emitter coupled to an emitter support structure, and an electrode assembly including an electrode stack and a plurality of bias electrodes. The emitter assembly including a plurality of independent components that are coupled together. The electrode assembly including a plurality of independent components that are coupled together, and the emitter assembly being coupled to the electrode assembly.

Abstract: The present disclosure provides compositions comprising an oligosaccharide of formula (I), wherein said compositions are useful for delivery of certain agents, including, for example, nucleic acids.

Abstract: The present disclosure provides a compound of formula I, as well as complexes and compositions comprising a compound of formula I, wherein said compositions and complexes are useful for delivery of certain agents, including, for example, nucleic acids.

Abstract: The present disclosure provides compounds, compositions, and complexes useful for delivery of certain agents, including, for example, nucleic acids.

Abstract: The present disclosure provides methods and compositions useful for generating cellular models of VWF disease from human pluripotent stem cells. In one aspect, the present disclosure relates to a method for the generation of an in vitro cellular model of VWF disease comprising VWF disease-relevant endothelial cells derived from human pluripotent stem cells (hPSCs). In an embodiment, the human pluripotent stem cells (hPSCs) are treated with an agent effective in suppressing or deleting at least one gene sequence encoding a protein and/or a subunit thereof, where the protein and/or subunit thereof is associated with VWF-linked secretion. The present disclosure also provides uses of the cellular models disclosed herein.

Abstract: A mobile kit for imaging microscopic organisms in a liquid sample, comprises a slide having a liquid sample chamber with a liquid sample inlet, and a slide reader containing a lens and configured to receive the slide and image the liquid sample chamber through the lens using a mobile imaging device that is coupled to the slide reader. The liquid sample chamber of the slide is a linear elongated liquid sample chamber, and the slide reader comprises a track configured to receive the slide and guide movement of the slide along the track allowing the length of the linear elongated liquid sample chamber to be imaged through the lens and a drive module configured to move the slide along the track.

Abstract: A cooling/heating method including the application and removal of a pressurising gas on a hybrid organic-inorganic porous material (MOF) whereby a breathing transition is produced. In this transition, a change in volume in the structure of the compound occurs when its pores open/close, together with adsorption/desorption of a gas after applying and removing a pressurising gas on the compound; and breathing which occurs at temperatures close to ambient temperature (from ?20° C. to 60° C.) and at low pressures (from 10?5 bar up to 50 bar) and with great isothermal entropy changes (>100 J K?1 kg?1). A cooling/heating device comprising the hybrid materials defined above.

Abstract: Embodiments described herein address the problem of treating or ameliorating fungal infections and biofilm formation, and in particular Candida infection. Certain aspects are directed to anti-fungal compounds and compositions.

Abstract: The present invention relates to 1,2-dihydroquinoline-2-ones of formula (I): or a pharmaceutically acceptable salt or solvate thereof, for its use in the treatment of limb girdle muscular dystrophy.

Abstract: Various systems and methods are provided for a biased cathode assembly of an X-ray tube with improved thermal management and a method of manufacturing same. In one example, a cathode assembly of an X-ray tube comprises an emitter assembly including an emitter coupled to an emitter support structure, and an electrode assembly including an electrode stack and a plurality of bias electrodes. The emitter assembly including a plurality of independent components that are coupled together. The electrode assembly including a plurality of independent components that are coupled together, and the emitter assembly being coupled to the electrode assembly.

Abstract: The present invention relates to 2,4-disubstituted thiadiazolidinones of formula (I): or a pharmaceutically acceptable salt or solvate thereof, for its use in the treatment of limb girdle muscular dystrophy.

Abstract: Disclosed is a method for producing products from warm dough, which includes producing a dough by means of cooking; dispensing the dough into a first container up to a predetermined level; inserting, while the dough is warm, a first forming cutting mold provided with a plurality of tubular cells in the shape of the product to be obtained, for example, a croquette, to fill each of the cells with the dough; and rapidly cooling, thereby forming the croquettes, which are pushed out by means of a first ejector mold to obtain a plurality of croquettes simultaneously. Any leftover dough is dispensed warm into a second container provided with a movable separator, which moves after dispensing, until the dough reaches the predetermined level, and the previous steps are repeated.

Abstract: Described herein is a facile, fast, and economical method for the synthesis of BAL-mediated PVP-BiNPs, using basic laboratory instruments and reagents readily available in most laboratories.

Abstract: Various systems and methods are provided for a biased cathode assembly of an X-ray tube with improved thermal management and a method of manufacturing same. In one example, a cathode assembly of an X-ray tube comprises an emitter assembly including an emitter coupled to an emitter support structure, and an electrode assembly including an electrode stack and a plurality of bias electrodes. The emitter assembly including a plurality of independent components that are coupled together. The electrode assembly including a plurality of independent components that are coupled together, and the emitter assembly being coupled to the electrode assembly.

Abstract: Disclosed is a method for producing products from warm dough, which includes producing a dough by means of cooking; dispensing the dough into a first container up to a predetermined level; inserting, while the dough is warm, a first forming cutting mold provided with a plurality of tubular cells in the shape of the product to be obtained, for example, a croquette, to fill each of the cells with the dough; and rapidly cooling, thereby forming the croquettes, which are pushed out by means of a first ejector mold to obtain a plurality of croquettes simultaneously. Any leftover dough is dispensed warm into a second container provided with a movable separator, which moves after dispensing, until the dough reaches the predetermined level, and the previous steps are repeated.

Abstract: A method for congestion control in a data communication protocol employing acknowledged communication may include measuring a flight size. A transmission rate may be measured. A trend of the flight size may be determined. A trend of the transmission rate may be determined, and the trend may be derived from a transmission rate gradient calculation, in which either the transmission rate measurements or the transmission rate gradient calculations or both may be filtered to reduce their temporal variability. Whether there is a congestion may be detected according to the determined trend of the transmission rate and the trend of the flight size. Upon detection of the congestion, a change may be made from a current congestion control state to a new congestion control state. Data may be transmitted while respecting a maximum amount of unacknowledged data which the transmitting node may transmit. An apparatus is also disclosed.

Abstract: A process for self-cleaning an electrolytic cell involves introducing a stream of seawater into the electrolytic cell having at least one cathode and one anode. The cathode and anode are substantially fully coated with a coating composition. A forward bias is applied between the anode and the cathode at a first current density as seawater flows between the electrodes. Subsequently, a reverse bias is provided at the cathode. The reverse bias is provided at a second current density that is lower than the first current density. When the reverse bias is applied, the polarity of the cathode is reversed for a short duration. This facilitates the generation of a small amount of hydrochloric acid at the previous cathode surface causing the dissolution of calcium, magnesium or other deposits on the surface of the electrodes without damaging the coating composition on the electrodes.

Abstract: A system for digital rights management including a processor in a platform and a memory device comprising instructions that when executed configure the processor to perform operations. The operations may include determining whether a digital media is locally installed in a platform before initiating an operating system, and launching a first UEFI application configured to generate attestation data and communicate attestation based data to a server through an encrypted medium in response to determining the digital media is not installed. The operations may also include receive a binary file of the digital media and a first decryption key and performing a sealing of the binary file using a sealing enclave of the first UEFI application and generating a local decryption second key based on the first key and local entropy. The operations may also include installing the sealed binary file on local storage.