Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.

Abstract: The present invention provides for closed loop multimedia content management systems and methods to ensure accurate and timely delivery of VOD content from multiple content providers using multiple distribution systems. The present invention provides for a method of distributing multimedia content using a VOD management system by receiving a multimedia asset data file and associated metadata from a content provider and/or a MSO, tracking the delivery of the multimedia asset data file to a MSO, tracking the upload of the multimedia asset data file to a VOD server maintained by the MSO, and providing usage reports relating to usage of multimedia asset data files by end users of the MSO. Usage reports are prepared by receiving data from the VOD servers regarding the files requested by end users, creating a master reporting database using that data, and generating the usage reports using the data contained in the master reporting database.

Abstract: The present invention provides for methods, systems, and devices for simultaneously receiving and processing multimedia asset packages transmitted by a plurality of multimedia content providers. The methods and systems of the present invention implement a multiport catcher appliance configured to receive a plurality of transmissions, simultaneously, from multiple content providers in a multimedia asset distribution system. The multimedia catcher receiver includes a multimedia network interface unit configured to simultaneously receive multimedia data segments from content providers, a multimedia network interface unit that provides the multimedia data segments to a receive unit, a receive unit configured to reconstruct and validate a multimedia asset package using multimedia data segments transmitted by a content provider, and a content management system to manage multimedia asset packages and provide multimedia asset packages to a multimedia server.

Abstract: An embodiment of the present invention is a technique to localize content management of media content assets. A local content is received at a regional media center. The local content corresponds to an event localized within a locality. The local content is prepared into an asset using a media content management system. An asset package containing the asset is propagated to a head-end for distribution to a subscriber in the locality. In another embodiment of the invention, an asset package containing an asset and asset attributes is received from a propagation unit. The asset is created from a local content corresponding to an event localized within a locality. The asset is distributed to a subscriber in the locality.

Abstract: An embodiment of the present invention is an on-line global media exchange (GMX) marketplace. The GMX marketplace manages media content participants. The participants include a first party and a second party. The first and second parties include at least one of a content owner, a buyer, an advertiser, and a third-party service provider. A transaction among the participants is executed via the on-line GMX marketplace. The transaction is customized according to, and negotiated between, the first and second parties.

Abstract: The present invention relates to chromium(III) complexes defined by following formula: wherein: each R1 is independently selected from hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, C6-C20 aryl, C2-C20 alkenyl, optionally comprising 1 to 5 heteroatoms such as Si, N, P, O, F, Cl, B; each R2 is independently selected from hydrogen, C1-C20 alkyl, C3-C20 cycloalkyl, silyl, C6-C20 aryl, C2-C20 alkenyl, optionally comprising 1 to 5 heteroatoms such as Si, N, P, O, F, Cl, B; R1 and R2 can join together forming one or more aromatic or aliphatic rings optionally containing heteroatoms; each A is independently selected from nitrogen, phosphorous, As, Sb; each E is independently selected from carbon, phosphorus, nitrogen; Z is a group comprising at least a nitrogen, phosphorous, oxygen or sulfur atom which is able to coordinate to the chromium atom; Z can join one or more R2 groups to form one or more rings; each p is independently 1 or 2; each n is independently 0, 1 or 2; each X is independently an atom or group cova

Abstract: A linear variable differential transformer (LVDT) system is disclosed. The system has an LVDT. A signal conditioner circuit is coupled to the LVDT. The signal conditioner circuit uses an inductance of the LVDT primary as a micro-power excitation carrier frequency to lower a drive power of the system. The signal conditioner circuit generates output currents that are summed and filtered to generate a position proportional voltage.

Abstract: An embodiment of the present invention is a technique to localize content management of media content assets. A local content is received at a regional media center. The local content corresponds to an event localized within a locality. The local content is prepared into an asset using a media content management system. An asset package containing the asset is propagated to a head-end for distribution to a subscriber in the locality. In another embodiment of the invention, an asset package containing an asset and asset attributes is received from a propagation unit. The asset is created from a local content corresponding to an event localized within a locality. The asset is distributed to a subscriber in the locality.

Abstract: A catalyst system, a polymerization process using that catalyst system and polymers produced therefrom. The catalytic system results from the combination of bridged indenyl metallocenes of general formula I and an organoaluminium or boron perfluorinated co-catalyst, where M is a transition metal of Group 4 of the Periodic Table of the elements, Q is a divalent substituent and X1 and X2 are monovalent anionic ligands. Polyethylene copolymers made with such catalysts can have from narrow to broad to bimodal molecular weight distribution and melt indexes from about 0 to higher than 10 without the need of molecular weight regulators, depending on proper selection of the indenyl substituent, number of substituents (single or both indenes substituted) and the type of stereoisomeric form used: pure (racemic or meso) or mixtures thereof.

Abstract: Catalyst component for the polymerization of alpha-olefins in solution, in suspension, in gas phase at low and high pressure and temperature or in mass at high pressures and high or low temperatures, characterised in that is defined by general formulas I or II wherein: R, equal to or different from each other, is hydrogen or a radical which contains from 1 to 20 carbon atoms; this group optionally contains heteroatoms of groups 14 to 16 of the periodic table of the elements and boron; at least one group R contains a group OSiR?3, Q is selected from a group comprising: boron or an element from groups 14 or 16 of the periodic table; m value can change from 1 to 4 and it preferably is 1 or 2; L, equal to or different from each other, is a cyclic organic group united to M through a ? bond, or it is an atom from groups 15 or 16 of the periodic table; L1 and L2, equal to or different from each other, have the same meaning of L; M is a metal from groups 3, 4, 10 of the periodic table, lanthanide or actinide.

Abstract: The present invention provides for methods, systems, and devices for simultaneously receiving and processing multimedia asset packages transmitted by a plurality of multimedia content providers. The methods and systems of the present invention implement a multiport catcher appliance configured to receive a plurality of transmissions, simultaneously, from multiple content providers in a multimedia asset distribution system. The multimedia catcher receiver includes a multimedia network interface unit configured to simultaneously receive multimedia data segments from content providers, a multimedia network interface unit that provides the multimedia data segments to a receive unit, a receive unit configured to reconstruct and validate a multimedia asset package using multimedia data segments transmitted by a content provider, and a content management system to manage multimedia asset packages and provide multimedia asset packages to a multimedia server.

Abstract: The present invention provides for closed loop multimedia content management systems and methods to ensure accurate and timely delivery of VOD content from multiple content providers using multiple distribution systems. The present invention provides for a method of distributing multimedia content using a VOD management system by receiving a multimedia asset data file and associated metadata from a content provider and/or a MSO, tracking the delivery of the multimedia asset data file to a MSO, tracking the upload of the multimedia asset data file to a VOD server maintained by the MSO, and providing usage reports relating to usage of multimedia asset data files by end users of the MSO. Usage reports are prepared by receiving data from the VOD servers regarding the files requested by end users, creating a master reporting database using that data, and generating the usage reports using the data contained in the master reporting database.