Patents by Inventor José Alejandro MADRIGAL

José Alejandro MADRIGAL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170246217
    Abstract: The present invention shows that CB plasma contains soluble NKG2D ligands and that the incubation of PBMCs with CB plasma results in decreased cytotoxicity, decreased proliferation and inhibition of IFNy production by NKG2D bearing cells, in particular, NK cells. Interaction of NKG2D with soluble NKG2D ligand leads to blocking of the NKG2D receptor, and renders NKG2D bearing cells refractory to activation and inhibits cell functions. Notably, this is a mechanism naturally employed by tumor cells or viruses such as CMV to escape the immune system.
    Type: Application
    Filed: September 16, 2015
    Publication date: August 31, 2017
    Inventors: Bernat SORIA ESCOMS, Abdelkrim HMADCHA, José Alejandro MADRIGAL, Aurore SAUDEMONT, Steven COX, Raquel LAZA