Patents by Inventor José Diago

José Diago has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lyophilization Process
    Publication number: 20090186865
    Abstract: An improved process for the production of lyophilized Piperacillin alone or in combination with Tazobactam with improved pH adjustment, by degassing the solution of products to a controlled low carbon dioxide content prior to lyophilization.
    Type: Application
    Filed: December 1, 2006
    Publication date: July 23, 2009
    Applicant: SANDOZ AG
    Inventors: José Diago, Joan Cabre, Josep Salvador, Pere Lloveras, Irina Kosilek, Norbert Atzl
  • Derivatives of azithromycin
    Patent number: 7410952
    Abstract: The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: August 12, 2008
    Assignee: Sandoz AG
    Inventors: Albert Codony, José Diago, Rafael Garcia, Jordi Rifa
  • Derivatives of azithromycin
    Publication number: 20070043214
    Abstract: The invention relates to derivatives of azithromycin, processes for the manufacture thereof and pharmaceutical compositions thereof preferably together with azithromycin.
    Type: Application
    Filed: April 16, 2004
    Publication date: February 22, 2007
    Inventors: Albert Codony, Jose Diago, Rafael Garcia, Jordi Rifa
  • Processes for the preparation of gabapentin
    Patent number: 7098362
    Abstract: The present invention relates to new processes for the preparation of gabapentin by the desilylation of a silylated gabapentin or by the silylation-desilylation of an acid addition salt of gabapentin with a silylating agent.
    Type: Grant
    Filed: July 19, 2005
    Date of Patent: August 29, 2006
    Assignee: Sandoz AG
    Inventors: Rafael Garcia, Johannes Ludescher, Jordi Rifa, José Diago
  • Processes for the preparation of Gabapentin
    Publication number: 20060020034
    Abstract: The present invention relates to new processes for the preparation of gabapentin by the desilylation of a silylated gabapentin or by the silylation-desilylation of an acid addition salt of gabapentin with a silylating agent.
    Type: Application
    Filed: July 19, 2005
    Publication date: January 26, 2006
    Inventors: Rafael Garcia, Johannes Ludescher, Jordi Rifa, Jose Diago
  • Macrolide solvates
    Patent number: 6949519
    Abstract: Azithromycin in the form of a monohydrate comprising from 4.0% to 6.5% of water, a process for its preparation and its use in pharmaceutical compositions.
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: September 27, 2005
    Assignee: Sandoz AG
    Inventors: Victor Centellas, José Diago, Rafael Garcia, Johannes Ludescher
  • Macrolide solvates
    Publication number: 20040053862
    Abstract: Azithromycin in the form of a monohydrate comprising from 4.0% to 6.5% of water, a process for its preparation and its use in pharmaceutical compositions.
    Type: Application
    Filed: October 10, 2003
    Publication date: March 18, 2004
    Inventors: Victor Centellas, Jose Diago, Rafael Garcia, Johannes Ludescher
  • Macrolides
    Patent number: 6703372
    Abstract: Azithromycin in the form of a stable monohydrate and processes for the preparation of azithromycin in the form of an, e.g. stable, monohydrate.
    Type: Grant
    Filed: December 18, 2001
    Date of Patent: March 9, 2004
    Assignee: Biochemie S.A.
    Inventors: Victor Centellas, Rafael Garcia, Marta Poch, José Diago, Johannes Ludescher, Immaculada Bosch
  • Macrolide intermediates in the preparation of clarithromycin
    Patent number: 6599886
    Abstract: The present invention relates to a process for the production of clarithromycin from an aqueous medium in anhydrous form and in the form of a hydrate.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: July 29, 2003
    Assignee: Biochemie S.A.
    Inventors: Victor Centellas, José Diago
  • Erthromycin a oxime solvates
    Patent number: 6504017
    Abstract: Erythromycin A oxime in the form of a hemihydrate.
    Type: Grant
    Filed: January 4, 2000
    Date of Patent: January 7, 2003
    Assignee: Biochemie S.A.
    Inventors: Immaculada Bosch, Victor Centellas, José Diago
  • Macrolide production
    Patent number: 6420537
    Abstract: A process for the production of azithromycins by methylation of the nitrogen atom in position 9 of the ring structure in 9-deoxo-9a-aza-9a-homoerythromycins in the presence of formaldehyde and in the presence of a reducing agent in non-halogenated solvent; and azithromycin which is free from halogenated organic solvent in a stable anhydrous form; or in the form of a solvate with non-halogenated solvent with the exception of water.
    Type: Grant
    Filed: November 7, 2000
    Date of Patent: July 16, 2002
    Assignee: Biochemie S.A.
    Inventors: Immaculada Bosch, Victor Centellas, José Diago
  • Macrolide intermediates in the preparation of clarithromycin
    Publication number: 20020025938
    Abstract: The present invention relates to a process for the production of clarithromycin from an aqueous medium in anhydrous form and in the form of a hydrate.
    Type: Application
    Filed: June 8, 2001
    Publication date: February 28, 2002
    Inventors: Victor Centellas, Jose Diago
  • Production of a crystalline salt of amoxicillin
    Patent number: 6103897
    Abstract: A process for the production of a crystalline salt of amoxicillin utilizing ethanol as a solvent, and crystallizing the salt of amoxicillin in the presence of a salifying compound.
    Type: Grant
    Filed: August 3, 1998
    Date of Patent: August 15, 2000
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Joan Cabre, Jose Diago, Asuncion Esteve, Johannes Ludescher
  • Silylation process
    Patent number: 5998610
    Abstract: A process for the silylation of 6-aminopenicillanic acid or 7-amino-desacetoxy-cephalosporanic acid by silylation in certain carboxylic acid esters and its use in the production of 6-alpha-aminoacyl-penicillins and 7-alpha-aminoacyl-desacetoxy-cephalosporins.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: December 7, 1999
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Victor Centellas, Jose Diago, Johannes Ludescher
  • Process for separating pivalic acid from spent reaction mixtures
    Patent number: 5990351
    Abstract: A process for recovering 2,2-dimethylpropanoic acid in highly pure form from a mixture of 2,2-dimethylpropanoic acid and impurities which may be obtained in the production of a beta lactam antibiotic, by degrading impurities and separating off the volatile fragments.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: November 23, 1999
    Assignee: Biochemie GmbH
    Inventors: Joan Cabre, Victor Centellas, Jose Diago, Asuncion Esteve, Joan Serrat
  • Processes for the production of 6-.alpha.-aminoacyl-penicillin and 7-.alpha .
    Patent number: 5840885
    Abstract: A new process is described for the production of 6-alpha-amino-penicillins and 7-alpha-amino-desacetoxy-cephalosporins free from halogen-containing solvents by acylating 6-APA, 7-ADCA or a derivative thereof in a halogen-free solvent.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 24, 1998
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Jose Diago, Johannes Ludescher
  • Beta lactam production
    Patent number: 5719276
    Abstract: A new process is described for the production of 6-alpha-amino-penicillins and 7-alpha-amino-desacetoxy-cephalosporins free from halogen-containing solvents by acylating 6-APA, 7-ADCA or a derivative thereof in a halogen-free solvent.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 17, 1998
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Jose Diago, Johannes Ludescher
  • Beta lactam production
    Patent number: 5608055
    Abstract: A new process is described for the production of 7-alpha-aminoacyl-cephalosporin free from halogen-containing solvents by acylating 7-amino-ceph-3-em-4-carboxylic acid or a derivative thereof in a halogen-free solvent.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 4, 1997
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Jose Diago, Johannes Ludescher
  • Process for preparing cephalosporins and intermediates therefor
    Patent number: 5037988
    Abstract: The invention relates to activated aminothiazolyl-oximinoacetic acid derivatives, their production and their use in the production of e.g. amides, in particular cephalosporin antibiotics.
    Type: Grant
    Filed: June 19, 1989
    Date of Patent: August 6, 1991
    Assignee: Gema S.A.
    Inventors: Jose Diago Meseguer, Asuncion Esteve Bianchini, Carlos E. Lenhardt Padro, Esteve Sans Pitarch
  • Piperazine intermediates
    Patent number: 5015736
    Abstract: A new compound called N,N'-carbonyl-bis-(4-ethyl-2,3-dioxo)-piperazine of Formula I ##STR1## A process for the preparation thereof based on the reaction of 4-ethyl-2,3-dioxo-piperazine or a trimethylsilyl derivative thereof with carbonyl chloride or a derivative thereof.The use of the compound of Formula I as an intermediate in the preparation of compounds of Formula II ##STR2## where R is a radical, substituted in alpha position, of a molecule of an acid selected from the group formed by phenylacetic acid, p-hydroxy phenylacetic acid, a 6-(phenylacetamido)-penicillanic acid and a 7-(phenylacetamido)-cephalosporanic acid.
    Type: Grant
    Filed: November 15, 1989
    Date of Patent: May 14, 1991
    Assignee: Gema, S.A.
    Inventors: Juan Cabre Castellvi, Jose Diago Meseguer, Asuncion Esteve Bianchini, Carlos E. Lenhardt Padro, Esteve Sans Pitarch