Abstract: The disclosed subject matter refers to hydroxyapatite and bioglass-based pellets of homogeneous size and spherical shape, whose interconnective porous structure, in the micrometer range, allows for an enhanced osteoconductivity and osteointegration, with specific application as a synthetic bone graft and to the respective production process. The production process is based on the pharmaceutical technology of extrusion and spheronization employing a porogenic agent and applying a sinterization stage in the presence of a vitreous liquid phase, which reverts on behalf of a higher reproducibility, superior yield and greater production capacity.

Abstract: The disclosed invention is based on hydroxyapatite, biocompatible glass and silicon, aiming to develop an improved bone substitute, which presents higher mechanical resistance, bioactivity and osteoregeneration, and susceptible of being used in several medical and surgical fields, with application in the treatment of bone disease caused by trauma or genetic factors, as osteoconductive support for cellular growth. The abovementioned bone substitute comprises hydroxyapatite, a biocompatible glass of the P2O5—CaO system in a percentage up to 10 wt % relatively to the hydroxyapatite weight, and a silicon source in a concentration up to 10 wt % relatively to hydroxyapatite and biocompatible glass weight.

Abstract: The present invention provides a synthetic silicon-substituted apatite or hydroxyapatite which comprises 0.1% to 5% by weight of silicon. The silicon-substituted apatite or hydroxyapatite may be used as a synthetic bone material for use in bone substitution, implants, fillers and cements, coatings for metallic implants, and for making hydroxyapatite-polymer composites. The silicon-substituted apatite is prepared by reacting a calcium salt or calcium hydroxide with orthophosphoric acid or a salt of orthophosphoric acid in the presence of a silicon-containing compound, the molar ratio of calcium ions to phosphorous-containing ions being from 1:0.5 to 1:0.7 and the molar ratio of calcium ions to silicon-containing ions being at least 1:0.2, whereby a precipitate of a silicon-substituted apatite is formed. On heating and/or sintering the silicon-substituted apatite at a temperature of from 500° C. to 1400° C.