Abstract: Provided herein are methods of manufacturing a mold, wherein the methods comprise: (a) applying one or more input parameters to determine effect on process constraints in making a solid mesh; (b) printing a block of a micro-architected material; (c) determining porosity of the block; (d) determining feasibility of the micro-architected material to print; (e) defining architecture parameters of the mold based on solid mesh input parameters; (f) printing the mold, wherein the feasibility is an ability to print the solid mesh without clogging solid mesh; wherein if the micro-architected material is found not feasible at step (d), the solid mesh input parameters are adjusted and steps (b)-(d) are repeated.

Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.

Abstract: The present disclosure provides a compound comprising a modified tetracycline derivative, covalently coupled through a linker to a low-hydrophobicity bioactive molecule useful for treating neurodegenerative diseases, wherein the modified tetracycline derivative is optionally defined by the following formula:

Abstract: The invention relates to a nutraceutical formulation of blueberry extract, fish oil (omega-3 and omega-6), recombinant human lactoferrin, vitamin A and vitamin E, for human oral consumption. The invention belongs to the field of ophthalmology and has been developed as a coadjuvant for preserving the health of the precorneal film and of the eye surface. This formulation contains an extract of natural origin (Vaccinium myrtillus L) with antioxidant and anti-inflammatory properties; it also uses eicosapentaenoic acid (EPA), omega-6, and docosahexaenoic acid (DHA), omega-3, obtained from fish oil and which, together with lactoferrin, vitamin A and vitamin E, improves tear quality, since these compounds have anti-microbial and anti-inflammatory effects. This formulation has been designed as a coadjuvant for preserving the health of the precorneal film.

Abstract: A system includes a wind turbine a wind and a first control device for controlling the wind turbine. The first control device is configured to acquire a yaw misalignment of the wind turbine, which yaw misalignment is a difference between the actual yaw angle and a wind direction at the wind turbine; and to determine at least one of a target pitch angle of the blade and a target torque of the generator based on the yaw misalignment to optimize a power output from the wind turbine. Further, a wind farm includes the system and a method of controlling a wind turbine.

Abstract: It is provided a method, device and system to facilitate the design or and architecture of a computer project and its subsequent automatic implementation, based on a hand-written/drawn draft (e.g. on paper). This draft directly becomes the tool that will be used, automatically, as the basis for the final computer project implementation.

Abstract: Provided herein is a stimulation and measurement device. The stimulation and measurement device includes a microwell plate having a top side, a bottom side, and at least one well extending from the top side towards the bottom side; a first assembly removably positioned on the top side of the microwell plate; a second assembly removably positioned on the bottom side of the microwell plate; and a microcontroller. The first assembly includes a first printed circuit board having at least one pair of stimulating light emitting diodes (LEDs) positioned thereon to align with one of the wells. The second assembly includes a second printed circuit board having at least one photodiode positioned thereon to align with one of the pairs of stimulating LEDs, and at least one excitation LED paired with each of the photodiodes. The microcontroller is configured to control the stimulating LED(s), the photodiode(s), and the excitation LED(s).

Abstract: CRISPNA, a new tool for genome editing and diagnosis. The present invention relates to methods and systems for genome editing and diagnosis, and specifically relates to use of Peptide Nucleic Acids (PNAs) to direct the Cas proteins to their DNA or RNA targets.

Abstract: Stable, macroscopic single-crystal chiral liquid crystal compositions are described. The compositions include a single-crystal chiral liquid crystal material on a patterned surface. The patterned surface seeds a particular crystallographic orientation at the substrate-liquid crystal interface. Also described are methods of forming the single-crystal chiral liquid crystal compositions.

Abstract: A method performed by a network node, for handling an outgoing call from a first user in a communications network. The network node receives a request for the outgoing call to be set up via a first persona out of multiple personas associated with the first user, which request is obtained as a voice instruction from the first user via a Digital Assistant device. The voice instruction comprises a personalized name associated with the first persona of the first user. The network node identifies among the multiple personas associated with the first user, an Internet Protocol Multimedia Subsystem (IMS) user ID corresponding to the first persona based on the personalized name received in the voice instruction. The network node sends to an IMS node in the communications network, the identified IMS user ID, and a request to initiate the outgoing call via the first persona of the first user.

Abstract: A floating platform for high-power wind turbines, comprising a concrete substructure, said concrete substructure forming the base of the platform, which remains semi-submerged in the operating position, and consisting of a square lower slab on which a series of beams and five hollow reinforced concrete cylinders are constructed, distributed at the corners and the center of said lower slab; a metal superstructure supported on the concrete substructure and forming the base for connection with the wind turbine tower, said tower being coupled at the center thereof; and metal covers covering each of the cylinders, on which the metal superstructure is supported and to which vertical pillars are secured, linked together by beams, which join at the central pillar by an element whereon the base of the wind turbine tower is secured.

Abstract: Method for repairing plastic dividers (1), having longitudinal internal cavities (100), by following the steps of: identifying and extracting the damaged areas to be repaired (2), some gaps (4) being defined, preparing inserts (5) with a shape matching the gaps (4), and attaching by heat welds (8) the inserts (5) in the gaps (4); wherein the damaged areas to be repaired are extracted by cuts (3) with a curved path, and wherein in the step of preparing the inserts (5), the inserts are machined with an outer edge (50) aligned with the edges (10) of the divider (1), and an inner edge (51) parallel to the curved path of the cut (3), there being defined between the cut (3) made in the divider (1) and the inner edge (51) of the insert (5) a filling space (7) for filling with filler material (8).

Abstract: A child safety device for medication dispenser including a bottom cap assembly, a top cap assembly. The bottom cap assembly is secured on top of a medication dispenser such as prescription bottles. The bottom cap assembly further includes pawls and a lever lock. On a top surface, the bottom cap includes at least one dosing aperture and dosage regimen indicia. The top cap assembly includes a top cap having an internal ratchet gear that, when mounted upon the bottom cap assembly, interacts with the pawls to permit rotation in only one direction. The top cap further includes stops that are configured to affix the top cap in predetermined positions. The present invention has a 2-step process, by depressing the arm lever to disengage it along the ratchet and pawl system. The user would then twist to move the cap to its respective indicia for its desired scheduling or to their dispensing opening.

Abstract: A computer-implemented method for dynamic, data-driven consolidation of user interface interactions requesting roadside assistance. The method includes identifying a data objective requiring user data, accessing user data, and determining whether the user data satisfies a confidence threshold. Based at least in part on the confidence threshold determination, one of a first data objective representation and a second data objective representation is displayed. A request for roadside assistance—following satisfaction of the confidence threshold—is also issued.

Abstract: A filter assembly includes a body of filter media, a seal, and a compression ring. The body of filter media having a first end surface, a second end surface spaced apart from and opposing the first end surface, and an outer surface extending between the first end surface and the second end surface. The seal surrounds the first end surface. The compression ring is disposed about the second end surface. The compression ring includes a first channel configured to allow fluid communication between the second end surface and the outer surface.

Abstract: Methods and systems for providing processed cocoa nibs are provided. The methods involve coarse grinding cocoa nibs to form a slurry and subjecting less than all of the cocoa slurry to refining. The refined and unrefined volumes or portions of cocoa slurry are then recombined to provide a recombined cocoa product. The cocoa nibs produced by the method may be further processed to provide cocoa liquor or chocolate.

Abstract: The present invention relates to a machine for filling bags with a granular product comprising a filling station, a welding station, and a cooling station. The machine comprises a supporting device for supporting the bags below the stations. The device comprises a supporting surface assembled in a pivoting manner on a pivot shaft, and actuating means. The supporting surface has a first supporting segment for supporting the bags of the filling and welding stations on one side of the pivot shaft and a second segment for supporting the bag of the cooling station on the opposite side of said pivot shaft. The supporting surface can pivot in an alternating manner around said pivot shaft for moving the base of the bag which, in operation, is located in the filling station during filling. The invention also relates to a filling method.

Abstract: The invention relates to a one-component powder coating composition comprising a curing system comprising a curable resin and one or more curing additives for curing the curable resin, wherein the powder coating composition comprises: —one powder coating component comprising the curable resin and the one or more curing additives; and—in the range of from 0.

Abstract: A filter assembly includes a body of filter media, a seal, and a compression ring. The body of filter media having a first end surface, a second end surface spaced apart from and opposing the first end surface, and an outer surface extending between the first end surface and the second end surface. The seal surrounds the first end surface. The compression ring is disposed about the second end surface. The compression ring includes a first channel configured to allow fluid communication between the second end surface and the outer surface.

Abstract: A one-component powder coating composition is provided comprising a curable resin and one or more curing additives for curing the curable resin, wherein the powder coating composition comprises: one powder coating component comprising the curable resin and the one or more curing additives; and 1.0 to 20 wt % of a dry-blended inorganic particulate additive consisting of inorganic components i), ii), and iii), wherein component i) is non-coated aluminium oxide or non-coated silica, component ii) is aluminium hydroxide and/or aluminum oxyhydroxide, and component iii) is silica, and wherein the powder coating component has a particle size distribution with a Dv90 of at most 50 ?m and a Dv50 of at most 30 ?m.