Patents by Inventor Josè L. Adrio

Josè L. Adrio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Penicillin conversion
    Patent number: 6383773
    Abstract: The present invention provides a biological system for expanding the dethiazolidine ring of penicillins into the dehydrothiazine ring of cephalosporins or cephalosporin precursors. In particular, the invention defines reaction conditions under which expandase enzyme can convert penicillin substrates other than penicillin N into cephalosporins. The invention therefore provides a relatively inexpensive, uncomplicated, and environmentally friendly biological system for cephalosporin production from penicillins, which system can replace the synthetic chemical approaches currently utilized. In particular, the invention provides a system for producing DOAG and/or DAG, which can be enzymatically converted into 7-ADCA and 7-ADAC, which, in turn, can be enzymatically or chemically converted into valuable cephalosporins of commerce.
    Type: Grant
    Filed: April 22, 1999
    Date of Patent: May 7, 2002
    Assignee: Massachusetts Institute of Technology
    Inventors: Arnold L. Demain, Hiroshi Cho, Jacqueline M. Piret, Josè L. Adrio, Maria-Josefa E. Fernandez, Marco A. Bàez-Vàsquez, Gilberto Hintermann
  • PENICILLIN CONVERSION
    Publication number: 20010006795
    Abstract: The present invention provides a biological system for expanding the dethiazolidine ring of penicillins into the dehydrothiazine ring of cephalosporins or cephalosporin precursors. In particular, the invention defines reaction conditions under which expandase enzyme can convert penicillin substrates other than penicillin N into cephalosporins. The invention therefore provides a relatively inexpensive, uncomplicated, and environmentally friendly biological system for cephalosporin production from penicillins, which system can replace the synthetic chemical approaches currently utilized. In particular, the invention provides a system for producing DOAG and/or DAG, which can be enzymatically converted into 7-ADCA and 7-ADAC, which, in turn, can be enzymatically or chemically converted into valuable cephalosporins of commerce.
    Type: Application
    Filed: April 22, 1999
    Publication date: July 5, 2001
    Inventors: ARNOLD L. DEMAIN, HIROSHI CHO, JACQUELINE M. PIRET, JOSE L. ADRIO, MARIA-JOSEFA E. FERNANDEZ, MARCO A. BAEZ-VASQUEZ, GILBERTO HINTERMANN