Abstract: Pharmaceutical compositions of the active substances glimepiride with metformin or its salts such as hydrochloride, succinate, fumarate, etc. are useful to control blood glucose in patients with type 2 diabetes. To prove the effectiveness of the combination, clinical studies were conducted that demonstrated the existence of not only an additive effect, but also a synergistic effect of the two drugs compared with monotherapy using only one of the drugs used in combination. In consequence, the combination may be used as an effective and safe therapy to control blood glucose in patients with type 2 diabetes, using different proportions of the active substances in combinations suitable for the needs of different patients.

Abstract: Pharmaceutical compositions of the active substances glimepiride with metformin or its salts such as hydrochloride, succinate, furmarate, etc. are useful to control blood glucose in patients with type 2 diabetes. To prove the effectiveness of the combination, clinical studies were conducted that demonstrated the existence of not only an additive effect, but also a synergistic effect of the two drugs compared with monotherapy using only one of the drugs used in combination. In consequence, the combination may be used as an effective and safe therapy to control blood glucose in patients with type 2 diabetes, using different proportions of the active substances in combinations suitable for the needs of different patients.

Abstract: Improved single-step process for preparing 7,16-deoxy-2-aza-10-O-cladinosyl-12-O-desosaminyl-4,5-dihydroxy-6-ethyl-3,5,9,11,13,15-hexamethylbicycle[11.2.1]hexadeca-1(2)-en-8-ona from erythromycin A, with high yield and under soft conditions suitable for its industrial production. The transformation of erythromycin A into an intermediate compound, called 6,9-iminoether, which is obtained in a single step, is achieved by forming the mesitylenesulfonyloxime “in situ” from erythromycin, which in the presence of a base in aqueous acetone undergoes a Beckmann's transposition creating the iminoether with the help of the hydroxyl in position 6 of the macrolide ring; this intermediary is transformed into the antibiotic 9-deoxo-9a-methyl-9a-aza-9a-homoerythromycin A, which is obtained by precipitation in hexane, thereby obtaining an innovative form, with an anhydrous crystalline structure and physical characteristics different from the forms known to date.