Abstract: AG5 andrographolide derivative for use in the treatment of the inflammatory reaction caused by a cytokine storm, particularly produced by CoViD-19, bacteria with superantigens or by CAR-T, TIL or BiTE cell therapies.

Abstract: The present invention relates to a system for the controlled fragmentation of solids by means of acoustic beams, comprising at least one acoustic beam generation unit (100); and one feedback and control unit (200) of said generation unit (100). Advantageously, the acoustic beams generated by the system are acoustic vortex beams; and the feedback and control unit (200) further comprises a feedback subsystem (12), configured to receive the information relating to the fragmented solids and to utilize it so as to adapt the operation of the acoustic beam generation unit (100). Given that the generation of shearing stresses is more efficient using vortex beams, the amplitudes of the ultrasonic field needed to fragment the calculi are much lower than in current extracorporeal shock wave lithotripsy techniques. Likewise, the system minimizes unwanted effects on soft tissues surrounding the solid.

Abstract: A novel radio frequency sequence, suitable for performing Magnetic Resonance Imaging (MRI) of 2-dimensional (2D) slices of samples exhibiting short magnetization coherence times (i.e., hard tissues). The SS-ZTE pulse sequence contains the following steps: a) magnetizing all spins in the sample from a longitudinal direction to the transverse plane; b) exciting the 2D slice of interest, which comprises the selective locking of said 2D sample slice magnetization while spoiling the magnetization in the rest of sample volume; c) making the magnetization of the selected 2D slice impervious to reconfigurations of the magnetic field gradients from slice selection to encoding and readout; d) reading out of the free induction decay signal of the sample; e) repeating steps (a-d) with different readout directions, so as to gather a corresponding number of radial spokes of the plane defined by the 2D sample slice.

Abstract: A planar-symmetry device for high-sensitivity gamma ray detection, which allows real-time tomography image reconstruction with very good spatial resolution. Advantageously, the multi-pinhole collimators of the device move during data collection and/or one or more of the pinholes thereof moves independently, thereby allowing possible artifacts resulting from overlap areas of the detector to be completely eliminated.

Abstract: A device for the detection of gamma rays used primarily in a PET scanner is based on a scintillator heterostructure combining the high stopping power of scintillators commonly used in PET scanners (such as L(Y)SO, BGO, etc.) and very fast scintillators based on polymers loaded with fast emitting dyes or nanocrystals, or thin layers of nanocrystals or multiple quantum well structures. The particular arrangement of this detector module allows combining all the important features of a high-performance Time-of-Flight PET (TOFPET) detector module, i.e., a high photoelectric detection efficiency for the gamma rays, a precise 3D information (including the depth of interaction DOI) of the gamma ray conversion in the module, and good energy resolution.

Abstract: A device for the detection of gamma rays presents a high resolution in the three-dimensional position of the impact of the gamma ray within one or more scintillation crystal blocks coupled to an array of photosensors, for the determination of the impact energy of said gamma ray, the determination of the instant in time when said impact occurred, the interaction depth and the determination of the time-of-flight. Advantageously, in said device, the scintillation crystal detection blocks are optically isolated, in such a way that the scintillation light can only exit said blocks via the output region; and the scintillation crystal detection blocks and the array of photosensors are disposed in direct optical coupling.

Abstract: The present invention relates to a method for obtaining elastic properties of a soft solid by means of quasi-omnidirectional transverse waves generated by a focused ultrasound beam, with a helical phase profile that produces an acoustic vortex that generates a transverse wave front, not only in the direction perpendicular to the ultrasound beam but also in the same direction as the ultrasound beam. The invention also allows control of the transverse wave front generated, which facilitates the carrying out of elastography studies at different frequencies and increases the amplitude of the transverse waves produced, thereby improving the signal-to-noise ratio.

Abstract: The invention relates to a device for the detection of gamma rays coming from a source without image truncation and without image overlapping, comprising, at least, two detection cells and each of said cells comprising a detection space adapted to receive the gamma rays that penetrate through an opening, wherein said detection space comprises one or more detection assemblies, with some of said assemblies being positioned such that they stand in the way of the gamma rays coming into the overlap volume thereof.

Abstract: The present invention relates to a method for the detection of gamma rays with the capacity to determine multiple interactions and the corresponding time sequence thereof. The method utilizes a device having: one or more detection means for detecting the energy load qi deposited on the coordinates (x, y, z) of a detecting element and the time instant ti corresponding to the detection of said deposition; electronic data reading and acquisition means connected to the detection means of the device, said electronic means being configured for capturing, digitizing, and transmitting the detection signals of the device; and at least one processing unit connected to the electronic means, configured with software and/or hardware means for recording and/or processing data generated by the electronic data reading and acquisition means.

Abstract: The invention relates to a device for the detection of gamma rays (1) coming from a source (2) without image truncation and without image overlapping, comprising, at least, two detection cells (3) and each of said cells comprising a detection space (7) adapted to receive the gamma rays (1) that penetrate through an opening (5), wherein said detection space (7) comprises one or more detection assemblies (8, 8?), with some of said assemblies (8?) being positioned such that they stand in the way of the gamma rays (1) coming into the overlap volume (11) thereof.

Abstract: A positron emission tomography (PET) assembly includes an annular housing and an annular scintillator disposed within the annular housing. The annular scintillator includes an annular, substantially continuous crystal scintillator tube configured to absorb ionizing radiation and to emit light energy. A plurality of photo detectors are annularly disposed around the annular scintillator within the annular housing and configured to detect the emitted light energy.

Abstract: The invention relates to a method for producing a lens for an ultrasound apparatus, as well as to an apparatus comprising the lens. The method comprises choosing a source point, providing a treatment volume situated inside a bone tissue model, providing a plurality of nodes distributed inside the treatment volume, and simulating the emission of a spherical wave from each of the nodes. Thus, a simulated wave front is created, in which each spherical wave has an amplitude and a phase, there being at least two nodes with different amplitudes and/or phases. The simulated wave front is received on a receiving surface. On the basis of the processed results, a holographic lens surface is designed, which can generate a wave pattern equivalent to the simulated wave.

Abstract: A PET imaging device for observing a brain includes a hollow three-dimensional structure with a shape capable of housing a head. The PET imaging device comprising multiple independent gamma ray detection modules that together form a structure capable of surrounding the head, said detection modules comprise continuous scintillation crystal blocks, wherein “continuous” means that the crystal blocks can be continuous in one or in two directions, each of the continuous scintillation crystal blocks has a polygonal main cross-section, and said structure is an elongated structure having a major axis in a direction corresponding to the front-nape direction and a shorter axis in a direction corresponding to a straight line joining ears on the head. The continuous scintillation crystal blocks are positioned adjacent to fit laterally in an exact manner with each other throughout their entire thickness, building a mosaic, without gaps between adjacent crystal blocks and without overlapping each other.

Abstract: A read network topology for a matrix output device with a number of outputs determined by cross-joining “m” rows and “n” columns comprises a basic filtering block replicated for all the outputs and separately assigned to each of the outputs; each filtering block contains two filtering circuits that have a common input connection to the assigned matrix output and that provide two separate symmetrical and filtered outputs; all the row outputs (i) from the same row “i” but from different columns are interconnected to an input of an amplifier linked to row “i”, and all the column outputs (j) from the same column “j” but from different rows are connected together to an input of an amplifier linked to column “j”, the complete topology appearing when “i” and “j” are expanded in the respective intervals thereof.

Abstract: A PET imaging device for observing a brain includes a hollow three-dimensional structure with a shape capable of housing a head. The PET imaging device comprising multiple independent gamma ray detection modules that together form a structure capable of surrounding the head, said detection modules comprise continuous scintillation crystal blocks, wherein “continuous” means that the crystal blocks can be continuous in one or in two directions, each of the continuous scintillation crystal blocks has a polygonal main cross-section, and said structure is an elongated structure having a major axis in a direction corresponding to the front-nape direction and a shorter axis in a direction corresponding to a straight line joining ears on the head. The continuous scintillation crystal blocks are positioned adjacent to fit laterally in an exact manner with each other throughout their entire thickness, building a mosaic, without gaps between adjacent crystal blocks and without overlapping each other.

Abstract: The invention relates to a PET imaging device for observing the brain, characterised by comprising a structure with a shape that is capable of accommodating a human head, having independent gamma-ray detection modules, said detection modules having continuous scintillation crystals with a polygonal main section, wherein all together the detection modules form a hollow three-dimensional structure that can surround the head, and with said three-dimensional structure being elongated and having a main axis in the direction corresponding to the forehead-nape direction and a shorter axis in the direction corresponding to the straight line joining the ears, and with the adjacent scintillation crystals fitting together laterally in a precise manner along their entire thickness, forming a mosaic-like structure, i.e. without leaving gaps and without overlapping with one another.

Abstract: The main object of the present invention relates to the design of magnetic coils. In particular, it is aimed at improving the design of magnetic coils to reach high and very fast magnetic fields. The present invention improves the design of one of the main components, gradient coils system, of imaging equipment based on the technique of magnetic resonance imaging (MRI). In this invention, a magnetic coil with incomplete geometrical configuration is provided. The magnetic coil is characterized in that at least one of its spirals is incomplete. The manufacturing method is based on combinatorial filling. In addition, the magnetic coil presented in this invention can achieve intense and fast magnetic gradients.

Abstract: The present invention refers to a method to reduce the number of signals to be read out in a detector characterized in that it comprises using a lower photosensor granularity at least at the center obtaining a granularity degree at the photosensor that is edge dependent, wherein the granularity at the detector corners can be higher than at any other detector zone or wherein the granularity at the detector edges can be higher than at any other detector zone, and wherein the number of signals to be read out is reduced by joining signals in at least the center zone of the detector, or is reduced by using different photosensor elements at the center of the photosensor with regard to the remaining photosensor zones, and its use in nuclear medicine imaging techniques.

Abstract: A gamma ray Compton TOF camera system includes multiple detector modules, each comprising a gamma radiation sensitive material and arranged in layers formed by one or more detector modules. The layers are placed such that they interfere an incoming gamma ray in order to completely or partially absorb it after one or more Compton interactions and are spatially separated in order to allow for the determination of the temporal order of each gamma ray interaction inside the camera system. The camera system also includes read out electronics and a Data Acquisition System where signals from the detector modules will be readout, digitized and sent to a processing unit, which is capable to obtain the 3D position, energy and temporal sequential order of the individual interactions produced by a single incident gamma ray.

Abstract: This disclosure describes an imaging radiation detection module with novel configuration of the scintillator sensor allowing for simultaneous optimization of the two key parameters: detection efficiency and spatial resolution, that typically cannot be achieved. The disclosed device is also improving response uniformity across the whole detector module, and especially in the edge regions. This is achieved by constructing the scintillation modules as hybrid structures with continuous (also referred to as monolithic) scintillator plate(s) and pixelated scintillator array(s) that are optically coupled to each other and to the photodetector.