Patents by Inventor José María Gorgojo Lobato

José María Gorgojo Lobato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7842821
    Abstract: The invention is aimed at a compound of formula (I) wherein n is 0, 1 or 2, R1 is a linear or branched alkyl group, R2 is selected from a substituted or non substituted alkyl group, substituted or non substituted aryl group, substituted or non substituted aralkyl group, substituted or non substituted heterocyclyl group, or a substituted or non substituted heterocyclylalkyl group. Another object of the invention is a process for obtaining these compounds from the corresponding compound with a hydroxy group in position 4 by means of reacting with a sulfonamide in the presence of a phosphine and a dialkyl azadicarboxylate. The deprotection of the compound of formula (I) gives rise to the corresponding amine. The intermediate and the processes described are very useful in the synthesis of pharmaceutical products.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: November 30, 2010
    Assignee: Ragactives, S.L.
    Inventors: José María Gorgojo Lobato, Luis Octavio Silva Guisasola, Jorge Martín Juárez
  • Publication number: 20090076287
    Abstract: The invention is aimed at a compound of formula (I) wherein n is 0, 1 or 2, R1 is a linear or branched alkyl group, R2 is selected from a substituted or non substituted alkyl group, substituted or non substituted aryl group, substituted or non substituted aralkyl group, substituted or non substituted heterocyclyl group, or a substituted or non substituted heterocyclylalkyl group. Another object of the invention is a process for obtaining these compounds from the corresponding compound with a hydroxy group in position 4 by means of reacting with a sulfonamide in the presence of a phosphine and a dialkyl azadicarboxylate. The deprotection of the compound of formula (I) gives rise to the corresponding amine. The intermediate and the processes described are very useful in the synthesis of pharmaceutical products.
    Type: Application
    Filed: November 4, 2005
    Publication date: March 19, 2009
    Applicant: RAGACTIVES, S.L.
    Inventors: Jose Maria Gorgojo Lobato, Luis Octavio Silva Guisasola, Jorge Martin Juarez
  • Patent number: 7057045
    Abstract: The 17?-(substituted)-3-oxo-?1,2-4-azasteroids (I), wherein R1 is C1–C4 alkyl, OR2, wherein R2 is a C1–C4 alkyl radical, or NR3R4, wherein R3 and R4, equal or different, represent hydrogen or a C1–C4 alkyl radical, can be obtained by means of a process comprising cleaving the oxazolidinedione ring present in a 2-(substituted)-3-hydroxyoxazolidinedione of formula (IV), wherein R5 is Br or trichloromethylsulfonyl, and removing the substituent at position 2, to form a double bond at position 1,2. Some compounds (I) are testosterone-5?-reductase inhibitors and can be used in the treatment of hyperandrogenic disorders.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: June 6, 2006
    Assignee: Ragactives, S.L.
    Inventors: Jose Maria Gorgojo Lobato, Antonio Lorente Bonde-Larsen, Jorge Martin Juarez
  • Publication number: 20040254209
    Abstract: The 17&bgr;-(substituted)-3-oxo-&Dgr;1,2-4-azasteroids (I), wherein R1 is C1-C4 alkyl, OR2, wherein R2 is a C1-C4 alkyl radical, or NR3R4, wherein R3 and R4, equal or different, represent hydrogen or a C1-C4 alkyl radical, can be obtained by means of a process comprising cleaving the oxazolidinedione ring present in a 2-(substituted)-3-hydroxyoxazolidinedione of formula (IV), wherein R5 is Br or trichloromethylsulfonyl, and removing the substituent at position 2, to form a double bond at position 1,2. Some compounds (I) are testosterone-5&agr;-reductase inhibitors and can be used in the treatment of hyperandrogenic disorders.
    Type: Application
    Filed: March 26, 2004
    Publication date: December 16, 2004
    Applicant: Ragactives, S.L.
    Inventors: Jose Maria Gorgojo Lobato, Antonio Lorente Bonde-Larsen, Jorge Martin Juarez