Patents by Inventor José Ángel TURIEL HERNANDEZ

José Ángel TURIEL HERNANDEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF UPADACITINIB
    Publication number: 20230139156
    Abstract: The invention relates to a process for the preparation of compounds of formula (I), which are useful intermediates in the synthesis of Upadacitinib and structurally related compounds, by using Weinreb amide (III), or an equivalent thereof, as key intermediate.
    Type: Application
    Filed: December 18, 2020
    Publication date: May 4, 2023
    Inventors: Yolanda FERNÁNDEZ SAINZ, Antonio LORENTE BONDE-LARSEN, Alfonso PÉREZ ENCABO, José Ángel TURIEL HERNANDEZ, José Enrique GÓMEZ PULIDO, Mario LADERAS MUÑOZ
  • Process and intermediates for the preparation of benzo[b]thiophene compounds
    Patent number: 11312708
    Abstract: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
    Type: Grant
    Filed: February 7, 2020
    Date of Patent: April 26, 2022
    Assignee: CRYSTAL PHARMA, S.A.U.
    Inventors: Alfonso Pérez Encabo, José Ángel Turiel Hernandez, Yolanda Fernández Sainz, Antonio Lorente Bonde-Larsen
  • Methods for the preparation of deoxycholic acid, and intermediates useful in the preparation of deoxycholic acid
    Patent number: 11117925
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: September 14, 2021
    Assignee: BIONICE, S.L.U.
    Inventors: Antonio Lorente Bonde-Larsen, Ignacio Herraiz Sierra, Yolanda Fernandez Sainz, Jose Luis Barredo Fuente, Alfonso Perez Encabo, Jose Angel Turiel Hernandez
  • Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
    Patent number: 11104702
    Abstract: A process for the preparation of obeticholic acid and derivatives thereof by: (a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof to obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereof and (b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: August 31, 2021
    Assignee: CRYSTAL PHARMA, S.A.U.
    Inventors: Ignacio Herráiz Sierra, Yolanda Fernández Sainz, Carlos Cordovilla Losada, Alfonso Pérez Encabo, José Angel Turiel Hernandez
  • PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20200262863
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to DCA and pharmaceutically acceptable salts thereof, the carbon atoms of which are derived partially or solely from plant sources.
    Type: Application
    Filed: October 24, 2018
    Publication date: August 20, 2020
    Inventors: Ignacio Herraiz Sierra, Alfonso Pérez Encabo, Antonio Lorente Bonde-Larsen, Francisco Javier Guerra Navarro, Yolanda Fernandez Sainz, José Luis Barredo Fuente, José Angel Turiel Hernandez
  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS
    Publication number: 20200172523
    Abstract: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
    Type: Application
    Filed: February 7, 2020
    Publication date: June 4, 2020
    Inventors: Alfonso PÉREZ ENCABO, José Ángel TURIEL HERNANDEZ, Yolanda FERNÁNDEZ SAINZ, Antonio LORENTE BONDE-LARSEN
  • PROCESS AND INTERMEDIATES FOR THE SYNTHESIS OF OBETICHOLIC ACID AND DERIVATIVES THEREOF
    Publication number: 20200165289
    Abstract: A process for the preparation of obeticholic acid and derivatives thereof by: (a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof to obtain a compound of formula (IIIa) and/or (IIIb), or salts or solvates thereof and (b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof
    Type: Application
    Filed: June 22, 2018
    Publication date: May 28, 2020
    Inventors: Ignacio HERRÁIZ SIERRA, Yolanda FERNANDEZ SAINZ, Carlos CORDOVILLA LOSADA, Alfonso PÉREZ ENCABO, José Angel TURIEL HERNANDEZ
  • Process and intermediates for the preparation of benzo[b]thiophene compounds
    Patent number: 10597386
    Abstract: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: March 24, 2020
    Assignee: Crystal Pharma, S.A.U.
    Inventors: Alfonso Pérez Encabo, José Ángel Turiel Hernandez, Yolanda Fernández Sainz, Antonio Lorente Bonde-Larsen
  • PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS
    Publication number: 20190040048
    Abstract: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
    Type: Application
    Filed: September 30, 2016
    Publication date: February 7, 2019
    Inventors: Alfonso PÉREZ ENCABO, José Ángel TURIEL HERNANDEZ, Yolanda FERNÁNDEZ SAINZ, Antonio LORENTE BONDE-LARSEN
  • METHODS FOR THE PREPARATION OF DEOXYCHOLIC ACID, AND INTERMEDIATES USEFUL IN THE PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20180305395
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to novel intermediates useful for the preparation of DCA and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 6, 2017
    Publication date: October 25, 2018
    Inventors: Antonio LORENTE BONDE-LARSEN, Ignacio HERRAIZ SIERRA, Yolanda FERNANDEZ SAINZ, Jose Luis BARREDO FUENTE, Alfonso PEREZ ENCABO, Jose Angel TURIEL HERNANDEZ
  • PREPARATION OF DEOXYCHOLIC ACID
    Publication number: 20180086786
    Abstract: The present invention relates to new and improved processes for the preparation of deoxycholic acid (DCA) and pharmaceutically acceptable salts thereof, as well as to DCA and pharmaceutically acceptable salts thereof, the carbon atoms of which are derived solely from plant sources.
    Type: Application
    Filed: December 4, 2017
    Publication date: March 29, 2018
    Inventors: Antonio LORENTE BONDE-LARSEN, Ignacio HERRAIZ SIERRA, Yolanda FERNANDEZ SAINZ, Jose Luis BARREDO FUENTE, Alfonso PEREZ ENCABO, Jose Angel TURIEL HERNANDEZ, Francisco Javier GUERRA NAVARRO
  • SYNTHESIS OF ABIRATERONE AND RELATED COMPOUNDS
    Publication number: 20140011992
    Abstract: The present invention relates to processes for obtaining abiraterone and derivatives thereof, such as abiraterone acetate, by means of a Suzuki coupling through a steroid borate of general formula (IV) or a C—C coupling through a steroid hydrazone of general formula (II), as well as to intermediates useful in said processes.
    Type: Application
    Filed: December 20, 2012
    Publication date: January 9, 2014
    Applicant: CRYSTAL PHARMA, S.A.U.
    Inventors: Alfonso Perez Encabo, Jose Angel Turiel Hernandez, Francisco Javier Gallo Nieto, Antonio Lorente Bonde-Larsen, Celso Miguel Sandoval Rodriguez