Abstract: The present invention provides a method for the treatment of cancer with erdafitinib.

Abstract: Recombinant microorganisms configured for enhanced production of compounds such as 2-pyrone-4,6-dicarboxylic acid (PDC) and methods of using the recombinant microorganisms for the production of these compounds. The recombinant microorganisms include one or more modifications that reduce 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) cis-trans isomerase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) methyl esterase activity, and/or vanillate/3-O-methylgallate O-demethylase activity. The recombinant microorganisms can be used to generate PDC from media comprising plant-derived phenolics, such as syringyl phenolics, guaiacyl phenolics, and p-hydroxyphenyl phenolics. The plant-derived phenolics can be derived from pretreated lignin, including depolymerized lignin or other chemically altered lignin.

Abstract: The present disclosure relates to a method of artisan bread production. In particular, the present disclosure provides methods for producing artisan breads with improved dough rheology (consistency), increased volume, porosity, textural shelf life, aroma and flavor, while maintaining a more uniform and aesthetically-pleasing shape with the use of organic acids and non-wheat flour.

Abstract: Drilling fluids having improved rheology under downhole temperature and pressure. The improved rheology (IR) drilling fluids are particularly suited for use in deepwater drilling operations. The IR drilling fluids are invert emulsion fluids with viscosifier to rheology modifier weight ratios between about 6 and about 14. The IR drilling fluids exhibit low shear yield point variance and/or yield point variance of below 60 percent based on high-temperature, high-pressure viscometer measurements.

Abstract: A shield assembly for a shaft includes a first tubular section having a first end and a second end and a second tubular section having a first end and a second end. The first and second tubular sections are each hollow receiving the shaft. The first tubular section includes a first outer diameter and the second tubular section includes a second outer diameter, the first outer diameter being greater than the second outer diameter. The first tubular section and the second tubular section are telescopically coupled to one another where the second tubular section is movably disposed at least partially within the first tubular section.

Abstract: Feederhouse gearboxes are provided for installation on combine harvesters. In embodiments, the feederhouse gearbox includes a gearbox housing, an output shaft rotatable about an output axis, and a primary drive input. The primary drive input is mechanically linked to an engine of the combine harvester when the feederhouse gearbox is installed thereon. A reverser drive input is mechanically linked to a reverser motor of the combine harvester when the feederhouse gearbox is installed on the combine harvester. The feederhouse gearbox further includes a selector mechanism within the gearbox housing and movable between a primary drive position and a reverser drive position, a primary gear train transmitting rotation from the primary drive input to the output shaft when the selector mechanism is in the primary drive position, and a reverser worm drive transmitting rotation from the reverser drive input to the output shaft when the selector mechanism is in the reverser drive position.

Abstract: Recombinant microorganisms configured for enhanced production of compounds such as 2-pyrone-4,6-dicarboxylic acid (PDC) and methods of using the recombinant microorganisms for the production of these compounds. The recombinant microorganisms include one or more modifications that reduce 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) cis-trans isomerase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) methyl esterase activity, and/or vanillate/3-O-methylgallate O-demethylase activity. The recombinant microorganisms can be used to generate PDC from media comprising plant-derived phenolics, such as syringyl phenolics, guaiacyl phenolics, and p-hydroxyphenyl phenolics. The plant-derived phenolics can be derived from pretreated lignin, including depolymerized lignin or other chemically altered lignin.

Abstract: Views of a virtual environment can be displayed on mobile devices in a real-world environment simultaneously for multiple users. The users can operate selections devices in the real-world environment that interact with objects in the virtual environment. Virtual characters and objects can be moved and manipulated using selection shapes. A graphical interface can be instantiated and rendered as part of the virtual environment. Virtual cameras and screens can also be instantiated to created storyboards, backdrops, and animated sequences of the virtual environment. These immersive experiences with the virtual environment can be used to generate content for users and for feature films.

Abstract: Drilling fluids having improved rheology under downhole temperature and pressure. The improved rheology (IR) drilling fluids are particularly suited for use in deepwater drilling operations. The IR drilling fluids are invert emulsion fluids with viscosifier to rheology modifier weight ratios between about 6 and about 14. The IR drilling fluids exhibit low shear yield point variance and/or yield point variance of below 60 percent based on high-temperature, high-pressure viscometer measurements.

Abstract: Views of a virtual environment can be displayed on mobile devices in a real-world environment simultaneously for multiple users. The users can operate selections devices in the real-world environment that interact with objects in the virtual environment. Virtual characters and objects can be moved and manipulated using selection shapes. A graphical interface can be instantiated and rendered as part of the virtual environment. Virtual cameras and screens can also be instantiated to created storyboards, backdrops, and animated sequences of the virtual environment. These immersive experiences with the virtual environment can be used to generate content for users and for feature films.

Abstract: The present invention relates to new vulcanisable elastomeric compositions for components of tyres, comprising modified silicate fibres as fillers. The silicate fibres are modified according to the process with controlled pH of the invention. In addition, the invention regards components of tyres, comprising elastomeric materials obtainable by vulcanisation of said compositions, and tyres for vehicles comprising one or more of said components. The vulcanised elastomeric materials according to the invention are characterised by good static and dynamic mechanical properties, in particular by particularly low hysteresis. Advantageously the tyres of the invention comprising one or more of said components have a limited rolling resistance.

Abstract: Views of a virtual environment can be displayed on mobile devices in a real-world environment simultaneously for multiple users. The users can operate selections devices in the real-world environment that interact with objects in the virtual environment. Virtual characters and objects can be moved and manipulated using selection shapes. A graphical interface can be instantiated and rendered as part of the virtual environment. Virtual cameras and screens can also be instantiated to created storyboards, backdrops, and animated sequences of the virtual environment. These immersive experiences with the virtual environment can be used to generate content for users and for feature films.

Abstract: The present invention provides a method for the treatment of cancer with erdafitinib.

Abstract: The animal waste-collecting device is adapted for use with a companion animal. The animal waste-collecting device is configured for use in the collection of the excrement of the companion animal. The animal waste-collecting device comprises a telescopic structure, a ring mount, a capture head, and a lamp. The ring mount attaches the capture head to the telescopic structure such that the faces of the capture head rotate relative to the center axis of the telescopic shaft. The capture head is configured for use with a disposable collection bag. The disposable collection bag attaches to the capture head such that the excrement is captured during the elimination process of the companion animal.

Abstract: An overheat detection system comprising a controller for declaring the overheat, and two wiring connections running along a monitored system and configured to react upon overheat. The controller is configured to determine an electrical status of each wiring connection at least between operative and inoperative, the inoperative status corresponding to an electrical anomaly thereof, and electrically connect or disconnect the wiring connections depending on the electrical status thereof, wherein the declaration of overheat is based on a dynamic reconfiguration of the overheat detection system.

Abstract: Systems and methods for automatically mapping English phonemes to graphemes to support better reading and spelling instruction may include a mapping process for systematically dividing text words into graphemes made up of one or more text characters corresponding to appropriately identified phonemes (which may be represented by one or more phonetic characters). The process may also include automatically correlating each phoneme of a word with a grapheme representing the phoneme in order to produce a phoneme-to-grapheme map that may be optimized for educational use. Some embodiments may include a teaching process for presenting the results of the mapping process to students.

Abstract: Views of a virtual environment can be displayed on mobile devices in a real-world environment simultaneously for multiple users. The users can operate selections devices in the real-world environment that interact with objects in the virtual environment. Virtual characters and objects can be moved and manipulated using selection shapes. A graphical interface can be instantiated and rendered as part of the virtual environment. Virtual cameras and screens can also be instantiated to created storyboards, backdrops, and animated sequences of the virtual environment. These immersive experiences with the virtual environment can be used to generate content for users and for feature films.

Abstract: A method for treating inflammation and/or autoimmune diseases comprises administering to a subject in need thereof, a composition comprising a CDK8 inhibitor. In another aspect, a method for increasing IL-10 production comprises administering to a subject in need thereof a CDK8 inhibitor. In another aspect, a method for enhancing Treg cell differentiation, comprising administering a composition comprising a CDK8 inhibitor. In certain example embodiments, the subject suffers from an inflammatory bowel disease. In certain other example embodiments, the subject requires immunosuppression to prevent rejection following a transplantation procedure.