Patents by Inventor Jos Prickaerts

Jos Prickaerts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR USE IN NEURODEGENERATIVE DISORDERS
    Publication number: 20240279183
    Abstract: The present invention relates to compounds, pharmaceutical compositions and medicaments suitable for use in the prevention and/or treatment of neurodegenerative disorders, such as for example demyelinating diseases. These compounds have been found to improve cognition and/or neuroplasticity as well as to induce and/or stimulate remyelination of the myelin sheet. Furthermore, the present invention relates to methods for synthesis of said compounds.
    Type: Application
    Filed: June 2, 2022
    Publication date: August 22, 2024
    Inventors: Tim Vanmierlo, Melissa Schepers, Elisabeth Piccart, Jos Prickaerts
  • SELECTIVE PDE4D INHIBITORS AGAINST DEMYELINATING DISEASES
    Publication number: 20210145838
    Abstract: The current invention relates to selective PDE4D inhibitors for use in the prevention and/or treatment of demyelinating diseases of the central nervous system and of the peripheral nervous system.
    Type: Application
    Filed: April 4, 2019
    Publication date: May 20, 2021
    Inventors: Tim Vanmierlo, Jos Prickaerts, Paul Wieringa
  • THE USE OF SGC ACTIVATORS AND SGC STIMULATORS FOR THE TREATMENT OF COGNITIVE IMPAIRMENT
    Publication number: 20210052528
    Abstract: The present invention relates to sGC activators and sGC stimulators for use in the treatment of cognitive impairment in a mammal in need of such treatment, in particular for use in the treatment of vascular dementia.
    Type: Application
    Filed: April 12, 2019
    Publication date: February 25, 2021
    Applicant: Bayer Aktiengesellschaft
    Inventors: Peter Sandner, Jos Prickaerts
  • Treatment of cognitive impairment with PDE4 inhibitor
    Patent number: 10357486
    Abstract: This invention relates to the treatment of varying degrees of cognitive impairment associated with, for example, aging, Alzheimer's disease, schizophrenia with low dose administration of a PDE4 inhibitor, specifically roflumilast.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: July 23, 2019
    Assignee: UNIVERSITEIT MAASTRICHT
    Inventors: Jos Prickaerts, Marlies van Duinen, Anke Sambeth, Arjan Blokland
  • Compounds having a selective PDE4D inhibiting activity
    Patent number: 10017480
    Abstract: Compounds of formula (I), wherein Z=cyclopentyl. cyclopropylmethyl, —CH3; R??—CH3, CHF2, X=formula (II) (III) (IV) (V) Y=—CO; —C?O(CH2), —CH(OH)—CH2, —CH2—C?O, —CH2—CH2—C?O; —CH2—CH(OH)—CH2, —CH2—CH(OCOR1)—CH2 NR2? —N(CH2—CH2OH)2, formula (VI) (VII) (VIII) (IX) (X) (XI) R1=optionally substituted C1-C8 alkyl, optionally substituted aryl; optionally substituted aralkyl, preferably C1-C3 alkyl, more preferably CH3; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; these compounds have a PDE4D inhibiting activity and can be used as a medicament for treating dementia, in particular Alzheimer disease, and for improving memory.
    Type: Grant
    Filed: February 10, 2015
    Date of Patent: July 10, 2018
    Assignees: UNIVERSITA DEGLI STUDI DI GENOVA, THE TRUSTEES OF COLUMBIA UNIVERSITY, MAASTRICHT UNIVERSITY
    Inventors: Olga Bruno, Chiara Brullo, Alessia Romussi, Ernesto Fedele, Roberta Ricciarelli, Ottavio Arancio, Jos Prickaerts
  • Treatment of Cognitive Impairment With PDE4 Inhibitor
    Publication number: 20150051254
    Abstract: This invention relates to the treatment of varying degrees of cognitive impairment associated with, for example, aging, Alzheimer's disease, schizophrenia with low dose administration of a PDE4 inhibitor, specifically roflumilast.
    Type: Application
    Filed: August 15, 2014
    Publication date: February 19, 2015
    Inventors: Jos Prickaerts, Marlies van Duinen, Anke Sambeth, Arjan Blokland
  • Treatment of Cognitive Impairment with Combination Therapy
    Publication number: 20150051246
    Abstract: Treatment of varying degrees of cognitive impairment associated with Alzheimer's disease with a combination of a phosphodiesterase 4 inhibitor and an acetylcholinestase inhibitor, including roflumilast and donepezil hydrochloride.
    Type: Application
    Filed: August 15, 2014
    Publication date: February 19, 2015
    Inventors: Tadataka Yamada, Jos Prickaerts, Marlies van Duinen, Anke Sambeth, Arjan Blokland