Abstract: An integration application comprising a plurality of components may be provided. The components may provide connections between systems. The integration application may be configured to allow the systems to exchange data. It may be determined that a new version of a first one of the components is a candidate for release. Prior to release of the new version of the first component, the integration application may be tested using the new version of the first component and an existing version of the first component. An instance of the integration application may be automatically caused to be upgraded to include the new version of the first component.

Abstract: This disclosure provides compounds of Formula I, II, and III and pharmaceutically acceptable salts thereof for use as mitochondrial uncouplers, where the variables, e.g. R1-R9, X1, X2, and Y1 are defined in the specification. The disclosure also provides pharmaceutical compositions comprising a compound or pharmaceutically acceptable salt of Formula I, II, or III, alone or in combination with another active compound. Compounds and compositions of Formula I, II, and III are useful for treating or preventing certain conditions such as obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Compounds of Formula I, II, and III are also useful for regulating glucose homeostatis and insulin action.

Abstract: A method for inhibiting corrosion of pipelines and other metal surfaces, particularly those used in the oil-and-gas industry, is disclosed. The method comprises treating a brine-exposed metal surface with a film-forming composition. The composition comprises a quaternary surfactant, which is made by reacting a polyalkylene glycol (PAG), a haloalkanoic acid, and a tertiary fatty amine that optionally incorporates amide or ester functionality. The surfactant comprises a PAG monoester quat and a PAG diester diquat and may have other components. The quaternary surfactants provide good corrosion protection and can partition effectively from an oily phase into a brine phase in the absence of agitation. The surfactants are easy to synthesize economically and have structures that can be tailored to meet local HLB requirements.

Abstract: Compositions may include those of the formula: (I) wherein R1 is an alkyl chain having a carbon number in the range of greater than 40 to 200, R2 is a multiester, R3 is hydrogen, an ion, or an alkyl chain having a carbon number in the range of 1 to 200, m is an integer selected from 0 to 4, and n is an integer selected from the range of 0 to 4, wherein the sum of m and n is 1 or greater. Compositions may include a reaction product of a polyisobutylene-substituted succinic anhydride and a hydroxy-functional dendrimer, wherein the molar ratio of polyisobutylene-substituted succinic anhydride to hydroxy-functional dendrimer is within the range of 10:1 to 30:1.

Abstract: Compositions may include those of the formula: (I) wherein R1 is an alkyl chain having a carbon number in the range of greater than 40 to 200, R2 is a multiester, R3 is hydrogen, an ion, or an alkyl chain having a carbon number in the range of 1 to 200, m is an integer selected from 0 to 4, and n is an integer selected from the range of 0 to 4, wherein the sum of m and n is 1 or greater. Compositions may include a reaction product of a polyisobutylene-substituted succinic anhydride and a hydroxy-functional dendrimer, wherein the molar ratio of polyisobutylene-substituted succinic anhydride to hydroxy-functional dendrimer is within the range of 10:1 to 30:1.

Abstract: The disclosure provides compounds of Formula (I-A) and (I-B) and the pharmaceutically acceptable salts thereof. The variables, R, R2, R3, X1, X2, X3, Y1, Y, and Z are defined herein. Certain compounds of Formula (I-A) and (I-B) act as selective mitochondrial protonophore uncouplers that do not affect plasma membrane potential. These compounds are useful for treating or decreasing the risk of conditions responsive to mitochondrial uncoupling, such as cancer, obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH), Because mitochondrial uncouplers decrease the production of reactive oxygen species (ROS), which are known to contribute to age-related cell damage, the compounds are useful for increasing lifespan. Compounds and salts of Formulae (I-A) and (I-B) are also useful for regulating glucose homeostasis or insulin action in a patient.

Abstract: The present invention is directed to compositions containing polymer matrix, fiber and/or additives which are suitable for load bearing applications for medical devices. The matrix can be formed from a group of polymers which resorb inside the body after implantation. These compositions contain reinforcing fibers that are incorporated into a resorbable polymer matrix to improve properties such as mechanical. The reinforcing fibers can be resorbable, non-resorbable, natural, or metallic. Additives can be incorporated into the matrix material or the fibers or both to provide a secondary effect. These additives can be bioceramics to provide an osteoconductive effect; antimicrobial particles such as silver; coloring agents, and radiopaque additives to make the implants visible under fluoroscopy. The additives may also contribute to improve mechanical properties.

Abstract: A method for inhibiting corrosion of pipelines and other metal surfaces, particularly those used in the oil-and-gas industry, is disclosed. The method comprises treating a brine-exposed metal surface with a film-forming composition. The composition comprises a quaternary surfactant, which is made by reacting a polyalkylene glycol (PAG), a haloalkanoic acid, and a tertiary fatty amine that optionally incorporates amide or ester functionality. The surfactant comprises a PAG monoester quat and a PAG diester diquat and may have other components. The quaternary surfactants provide good corrosion protection and can partition effectively from an oily phase into a brine phase in the absence of agitation. The surfactants are easy to synthesize economically and have structures that can be tailored to meet local HLB requirements.

Abstract: A non-toxic, alcohol-free disinfectant and sanitizing composition comprising a non-ionic surfactant system, an alkylated vegetable oil, a sodium-containing base, benzalkonium chloride, citric acid and purified water for use on skin, hands and hard surfaces. The materials from which it is manufactured are all renewable, non-toxic, alcohol-free, nonflammable and the composition is readily biodegradable. The composition does not rely upon alcohol to produce its antimicrobial effects. The invention provides effective alternative to alcohol-based disinfectant and sanitizers and may be particularly useful in personal care and cleaning household products for schools, hospitals, restaurants, hotels and supermarkets. Furthermore, the invention also met the Environmental Protection Agency (EPA) standards and protocols for disinfectants on hard surfaces.

Abstract: A wireless ranging system (700) estimates a distance (703) between wireless devices (701, 702) by calibrating the devices through exchanging calibration packets (512, 524) to adjust transceiver settings for performing phase measurements at the wireless devices, and then transmitting a measurement packet (704) from a first wireless device to a second wireless device to synchronize the first and second wireless devices and to perform a two-way IQ data capture sequence at different carrier frequencies during processing of the measurement packet so that the first and second wireless devices each measure phase values for each of the plurality of different carrier frequencies, where the phase values at each of the first and second wireless devices are processed to generate a combined phase offset vector which is processed to determine a first estimated distance between the first and second wireless devices.

Abstract: A waste treatment unit. It comprises at least one gasifier having a main receptacle (1) with a waste inlet (2), a syngas outlet (6) and an ashtray outlet (8). In the interior of the receptacle there is a body (4) with at least one inclined section (7) disposed opposite to the waste inlet (2), and with a base (14) which creates a depletion shaft (17) that prevents the passage of waste; and a dividing wall (9a) in contact with said body (4) or an evacuation tube (9a) in the interior of the body (4), such as to create a waste zone (15) that encompasses at least the zone where the inclined section (7) is located, and a waste-free zone (16) wherethrough the syngas produced during oxidation of the waste flows towards the syngas outlet (6).

Abstract: A wireless ranging system (700) estimates a distance (703) between wireless devices (701, 702) by calibrating the devices through exchanging calibration packets (512, 524) to adjust transceiver settings for performing phase measurements at the wireless devices, and then transmitting a measurement packet (704) from a first wireless device to a second wireless device to synchronize the first and second wireless devices and to perform a two-way IQ data capture sequence at different carrier frequencies during processing of the measurement packet so that the first and second wireless devices each measure phase values for each of the plurality of different carrier frequencies, where the phase values at each of the first and second wireless devices are processed to generate a combined phase offset vector which is processed to determine a first estimated distance between the first and second wireless devices.

Abstract: Compositions may include those of the formula: (I) wherein R1 is an alkyl chain having a carbon number in the range of greater than 40 to 200, R2 is a multiester, R3 is hydrogen, an ion, or an alkyl chain having a carbon number in the range of 1 to 200, m is an integer selected from 0 to 4, and n is an integer selected from the range of 0 to 4, wherein the sum of m and n is 1 or greater. Compositions may include a reaction product of a polyisobutylene-substituted succinic anhydride and a hydroxy-functional dendrimer, wherein the molar ratio of polyisobutylene-substituted succinic anhydride to hydroxy-functional dendrimer is within the range of 10:1 to 30:1.

Abstract: Compositions may include those of the formula: (I) wherein R1 is an alkyl chain having a carbon number in the range of greater than 40 to 200, R2 is a multiester, R3 is hydrogen, an ion, or an alkyl chain having a carbon number in the range of 1 to 200, m is an integer selected from 0 to 4, and n is an integer selected from the range of 0 to 4, wherein the sum of m and n is 1 or greater. Compositions may include a reaction product of a polyisobutylene-substituted succinic anhydride and a hydroxy-functional dendrimer, wherein the molar ratio of polyisobutylene-substituted succinic anhydride to hydroxy-functional dendrimer is within the range of 10:1 to 30:1.

Abstract: The disclosure provides compounds of Formula (I-A) and (I-B) and the pharmaceutically acceptable salts thereof. The variables, R, R2, R3, X1, X2, X3, Y1, Y, and Z are defined herein. Certain compounds of Formula (I-A) and (I-B) act as selective mitochondrial protonophore uncouplers that do not affect plasma membrane potential. These compounds are useful for treating or decreasing the risk of conditions responsive to mitochondrial uncoupling, such as cancer, obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH), Because mitochondrial uncouplers decrease the production of reactive oxygen species (ROS), which are known to contribute to age-related cell damage, the compounds are useful for increasing lifespan. Compounds and salts of Formulae (I-A) and (I-B) are also useful for regulating glucose homeostasis or insulin action in a patient.

Abstract: The present invention is directed to compositions containing polymer matrix, fiber and/or additives which are suitable for load bearing applications for medical devices. The matrix can be formed from a group of polymers which resorb inside the body after implantation. These compositions contain reinforcing fibers that are incorporated into a resorbable polymer matrix to improve properties such as mechanical. The reinforcing fibers can be resorbable, non-resorbable, natural, or metallic. Additives can be incorporated into the matrix material or the fibers or both to provide a secondary effect. These additives can be bioceramics to provide an osteoconductive effect; antimicrobial particles such as silver; coloring agents, and radiopaque additives to make the implants visible under fluoroscopy. The additives may also contribute to improve mechanical properties.

Abstract: The present invention is directed to bioresorbable polymer blend compositions with tunable mechanical properties for manufacturing medical devices. These blends are multicomponent blends, comprise multiple polymer components and may or may not require additives in the form of fibers or particles for the potential enhancement of mechanical and/or biological properties.

Abstract: A securing system for a luminaire can include a first cable that is configured to be disposed at least partially within a cavity of the luminaire. The securing system can also include a first securing mechanism that receives a first portion of the first cable, where the first securing mechanism is coupled to a first component of the luminaire, where the first securing mechanism has a motile setting and a non-motile setting. The securing system can further include a second securing mechanism that receives a second portion of the first cable, where the second securing mechanism is coupled to a second component of the luminaire. The first securing mechanism, when in the non-motile setting, can secure the first component and the second component in a fixed position relative to each other using the first cable.

Abstract: This disclosure provides compounds of Formula I, II, and III and pharmaceutically acceptable salts thereof for use as mitochondrial uncouplers, where the variables, e.g. R1-R9, X1, X2, and Y1 are defined in the specification. The disclosure also provides pharmaceutical compositions comprising a compound or pharmaceutically acceptable salt of Formula I, II, or III, alone or in combination with another active compound. Compounds and compositions of Formula I, II, and III are useful for treating or preventing certain conditions such as obesity, type II diabetes, fatty liver disease, insulin resistance, Parkinson's disease, ischemia reperfusion injury, heart failure, non-alcoholic fatty liver disease (NALFD), and non-alcoholic steatohepatitis (NASH). Compounds of Formula I, II, and III are also useful for regulating glucose homeostatis and insulin action.

Abstract: Methods may include emplacing into a hydrocarbon production stream a composition containing an asphaltene inhibitor, wherein the asphaltene inhibitor includes the formula: wherein R1 is an alkyl chain having a carbon number in the range of greater than 40 to 200, R2 is a multiester group, R3 is hydrogen, an ion, or an alkyl chain having a carbon number in the range of 1 to 200, m is an integer selected from 0 to 4, and n is an integer selected from the range of 0 to 4, wherein the sum of m and n is 1 or greater.