Abstract: The invention provides a robust method to detect cancer in DNA extracted from an exploratory tissue biopsy or plasma sample obtained from a patient, comprising measuring a level of DNA methylation at a plurality of defined differentially methylated regions of the genome comprising multiple CpG sites.

Abstract: The invention relates to a robot for tightening bolt nuts on a vehicle chassis, the robot comprising a polyarticulated arm at the end of which is a nut tightening tool. A sleeve-shaped centering member is fixed around the nut tightening tool and comprises a frustoconical surface which makes it possible, on contact with a nut, to reposition the nut tightening tool automatically in the axis of the nut.

Abstract: Compounds are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

Abstract: A wing having a main wing section with a forward spar and an aft spar extending through an internal cavity. The forward and aft spars are spaced apart and delimiting a dry segment of the internal cavity. A winglet is rotatably coupled to the main wing section by a cant hinge defining a cant axis about which the winglet rotates relative to the main wing section between an extended position in which the winglet is aligned with the main wing section, and a folded position in which the winglet is rotated about the cant axis. A linkage assembly disposed in the dry segment is pivotably mounted to one of the forward and aft spars and is coupled to the cant hinge. The linkage assembly is displaceable to apply a force to move the winglet between the extended position and the folded position during flight of the aircraft.

Abstract: Compounds are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

Abstract: The invention relates to a robot for tightening bolt nuts on a vehicle chassis, the robot comprising a polyarticulated arm at the end of which is a nut tightening tool. A sleeve-shaped centering member is fixed around the nut tightening tool and comprises a frustoconical surface which makes it possible, on contact with a nut, to reposition the nut tightening tool automatically in the axis of the nut.

Abstract: Compounds are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

Abstract: Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

Abstract: A wing having a main wing section with a forward spar and an aft spar extending through an internal cavity. The forward and aft spars are spaced apart and delimiting a dry segment of the internal cavity. A winglet is rotatably coupled to the main wing section by a cant hinge defining a cant axis about which the winglet rotates relative to the main wing section between an extended position in which the winglet is aligned with the main wing section, and a folded position in which the winglet is rotated about the cant axis. A linkage assembly disposed in the dry segment is pivotably mounted to one of the forward and aft spars and is coupled to the cant hinge. The linkage assembly is displaceable to apply a force to move the winglet between the extended position and the folded position during flight of the aircraft.

Abstract: The design and synthesis of a novel bis-furan scaffold tailored for high efficiency at inhibiting transthyretin amyloid formation is reported. In vitro results show that the discovered compounds are more efficient inhibitors of amyloid formation than tafamidis, a drug currently used in the treatment of familial amyloid polyneuropathy (FAP), despite their lower molecular weight and lipophilicity. Moreover, ex vivo experiments with the strongest inhibitor in the series, conducted in human blood plasma from normal and FAP Val30Met-transthyretin carriers, disclose remarkable affinity and selectivity profiles. The promises and challenges facing further development of this compound are discussed under the light of increasing evidence implicating transthyretin stability as a key factor not only in transthyretin amyloidoses and several associated co-morbidities, but also in Alzheimer's disease.

Abstract: Compounds of formula (II) are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).

Abstract: The design and synthesis of a novel bis-furan scaffold tailored for high efficiency at inhibiting transthyretin amyloid formation is reported. In vitro results show that the discovered compounds are more efficient inhibitors of amyloid formation than tafamidis, a drug currently used in the treatment of familial amyloid polyneuropathy (FAP), despite their lower molecular weight and lipophilicity. Moreover, ex vivo experiments with the strongest inhibitor in the series, conducted in human blood plasma from normal and FAP Val30Met-transthyretin carriers, disclose remarkable affinity and selectivity profiles. The promises and challenges facing further development of this compound are discussed under the light of increasing evidence implicating transthyretin stability as a key factor not only in transthyretin amyloidoses and several associated co-morbidities, but also in Alzheimer's disease.

Abstract: An apparatus for allocating computer memory for memory diagnostics is disclosed. The apparatus may include a processor and memory that stores code executable by the processor, and may include code that identifies an unreserved amount of memory in a computer system, code that requests a portion of the memory based on the unreserved amount of memory, and code that determines whether an allocated portion of the memory comprises non-contiguous memory addresses. In some embodiments, the apparatus includes code that locks the allocated portion of the memory in response to the allocated portion consisting solely of contiguous memory addresses, and code that performs a memory diagnostic test on the allocated portion of the memory.

Abstract: For performing advanced memory test diagnostics, an apparatus, method, and computer program product are disclosed. The apparatus may include a processor, a memory that stores code executable by the processor, an address space module that identifies an address space having a plurality of blocks of memory addresses, a memory diagnostic module that performs, at least three times, a memory test procedure using a block pattern, wherein a first block pattern is used the first time, a second block pattern is used the second time, and a third block pattern is used the third time, and a memory fault module that determines the presence of a memory fault based on results of the memory test procedures.

Abstract: A block for construction of foundation systems retaining walls and gabions and to methods to build walls or gabions from said block. The block is comprised by at least two sides or faces of rectangular and flat configuration (1 and 2); at least one side or face (3) which has at least one of the ends in convex form; at least two sides or faces (4 and 5) which have at least one of its ends in convex form and that together with the convex end of the side or face (3) can provide said block with an apex (6) and respective geodynamic form. The present block is intended for the civil construction sector, more specifically for the construction of retaining walls by means of blocks or applying formwork with the form of the blocks.

Abstract: For performing advanced memory test diagnostics, an apparatus, method, and computer program product are disclosed. The apparatus may include a processor, a memory that stores code executable by the processor, an address space module that identifies an address space having a plurality of blocks of memory addresses, a memory diagnostic module that performs, at least three times, a memory test procedure using a block pattern, wherein a first block pattern is used the first time, a second block pattern is used the second time, and a third block pattern is used the third time, and a memory fault module that determines the presence of a memory fault based on results of the memory test procedures.

Abstract: An apparatus for allocating computer memory for memory diagnostics is disclosed. The apparatus may include a processor and memory that stores code executable by the processor, and may include code that identifies an unreserved amount of memory in a computer system, code that requests a portion of the memory based on the unreserved amount of memory, and code that determines whether an allocated portion of the memory comprises non-contiguous memory addresses. In some embodiments, the apparatus includes code that locks the allocated portion of the memory in response to the allocated portion consisting solely of contiguous memory addresses, and code that performs a memory diagnostic test on the allocated portion of the memory.

Abstract: A block for construction of foundation systems retaining walls and gabions and to methods to build walls or gabions from said block. The block is comprised by at least two sides or faces of rectangular and flat configuration (1 and 2); at least one side or face (3) which has at least one of the ends in convex form; at least two sides or faces (4 and 5) which have at least one of its ends in convex form and that together with the convex end of the side or face (3) can provide said block with an apex (6) and respective geodynamic form. The present block is intended for the civil construction sector, more specifically for the construction of retaining walls by means of blocks or applying formwork with the form of the blocks.

Abstract: A prefabricated form assembly for making a concrete floor is disclosed. The form comprises an elongated form plate having a front for forming and retaining a flowable concrete material before it sets, anchor elements extending from the back face of the form plate, and being destined to be embedded into the concrete floor; and an L-shaped lintel having a back wall connected to the front face of the form plate and a bearing wall for supporting a masonry wall. Advantageously the construction of a concrete floor adapted to structurally retain a masonry wall using prefabricated form assemblies according to the invention no more requires the use of different groups of workers from different building trades as in the prior art, only one group of workers is required.

Abstract: A prefabricated form assembly for making a concrete floor is disclosed. The form comprises an elongated form plate having a front for forming and retaining a flowable concrete material before it sets, anchor elements extending from the back face of the form plate, and being destined to be embedded into the concrete floor; and an L-shaped lintel having a back wall connected to the front face of the form plate and a bearing wall for supporting a masonry wall. Advantageously the construction of a concrete floor adapted to structurally retain a masonry wall using prefabricated form assemblies according to the invention no more requires the use of different groups of workers from different building trades as in the prior art, only one group of workers is required.