Patents by Inventor Jose A. Lopez
Jose A. Lopez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240376437Abstract: The present disclosure provides methods and compositions useful for generating cellular models of VWF disease from human pluripotent stem cells. In one aspect, the present disclosure relates to a method for the generation of an in vitro cellular model of VWF disease comprising VWF disease-relevant endothelial cells derived from human pluripotent stem cells (hPSCs). In an embodiment, the human pluripotent stem cells (hPSCs) are treated with an agent effective in suppressing or deleting at least one gene sequence encoding a protein and/or a subunit thereof, where the protein and/or subunit thereof is associated with VWF-linked secretion. The present disclosure also provides uses of the cellular models disclosed herein.Type: ApplicationFiled: February 16, 2024Publication date: November 14, 2024Applicant: University of WashingtonInventors: Hongxia Fu, Benjamin Freedman, Jose A. Lopez
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Patent number: 11105820Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: GrantFiled: September 11, 2020Date of Patent: August 31, 2021Assignees: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20210088535Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: September 28, 2020Publication date: March 25, 2021Applicants: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20200408785Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: September 11, 2020Publication date: December 31, 2020Applicants: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 10794921Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: GrantFiled: July 27, 2018Date of Patent: October 6, 2020Assignees: University of Washington, Puget Sound Blood CenterInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20190041410Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: July 27, 2018Publication date: February 7, 2019Applicants: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 10073102Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: GrantFiled: February 17, 2017Date of Patent: September 11, 2018Assignees: University of Washington through its Center for Commercialization, BloodworksInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20170227555Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: February 17, 2017Publication date: August 10, 2017Applicants: University of Washington through its Center for Commercialization, Puget Sound Blood CenterInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 9599613Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: GrantFiled: July 20, 2012Date of Patent: March 21, 2017Assignees: University of Washington through its Center for Commercialization, Puget Sound Blood CenterInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Patent number: 9428454Abstract: A process for the complete or partial oxygenation of hydrocarbons comprises contacting a C1-C8 hydrocarbon, molecular oxygen, and hydrogen peroxide, in the presence of water and a heterogeneous catalyst, under conditions suitable to convert the C1-C8 hydrocarbon to at least one corresponding C1-C8 oxygenate product, wherein the heterogeneous catalyst provides confinement and contains both Brønsted-Lowry acid centers and Lewis acid centers. The reaction may be carried out at a temperature ranging from 2° C. to 90° C. The use of molecular oxygen increases the economic attractiveness of the process while also improving yield.Type: GrantFiled: October 3, 2012Date of Patent: August 30, 2016Assignee: University College Cardiff Consultants LimitedInventors: Graham J. Hutchings, Michael M. Forde, Jose A. Lopez-Sanchez, Nikolaos Dimitratos
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Publication number: 20160097033Abstract: The present disclosure provides devices composed of a three-dimensional biocompatible matrix having hematopoietic stem or other progenitor cells embedded in the matrix, and a perfusable microvessel forming a lumen disposed within the matrix. The devices are useful for production of blood and cells and particles and for in vitro assays. The present disclosure also provides methods for generating blood cells.Type: ApplicationFiled: October 6, 2015Publication date: April 7, 2016Inventors: Jose A. LOPEZ, Ying ZHENG, Sijie SUN, Surya KOTHA
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Patent number: 9155708Abstract: An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor ? (TNF?) over-expressed in a host microorganism.Type: GrantFiled: October 10, 2008Date of Patent: October 13, 2015Assignee: PROBELTE PHARMA, S.A.Inventors: Sergio A. Streitenberger, Marcos Peñalver Mellado, José A. López Más, Yolanda Pedreño López, Juan P. Sola González, Pedro Martínez Ortiz, Victoriano Mulero Mendez, Francisco Roca Soler, Jorge Galindo Villegas
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Patent number: 9132104Abstract: The present invention relates to nutritional products containing hydroxytyrosol, particularly fond products (i.e.: fortified edible oils and fortified edible oil-containing products) and dietary supplements (i.e.: soft gel capsules containing fortified edible oils) with increased antioxidant capacity to be used as a source of hydroxytyrosol for preventing or treating cardiovascular diseases, plaque build-up in the arteries, arterial hypertension, and metabolic syndrome, thanks to the nutritional supply of an hydroxytyrosol rich composition.Type: GrantFiled: November 5, 2012Date of Patent: September 15, 2015Assignee: PROBELTE PHARMA S.A.Inventors: Jose A. Lopez Mas, Marcos Penalver Mellado
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Publication number: 20150196498Abstract: Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).Type: ApplicationFiled: January 20, 2015Publication date: July 16, 2015Inventors: Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Penalver Mellado, Pedro Martinez Oritz
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Patent number: 8968811Abstract: Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).Type: GrantFiled: July 6, 2012Date of Patent: March 3, 2015Assignee: Probelte Pharma, S.A.Inventors: Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Peñ{tilde over ( )}alver Mellado, Pedro Martinez Ortiz
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Publication number: 20140315760Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.Type: ApplicationFiled: July 20, 2012Publication date: October 23, 2014Applicants: PUGET SOUND BLOOD CENTER, University of Washington through its Center for CommercializationInventors: Daniel M. Ratner, Jill M. Johnsen, James T. Kirk, José A. López, Norman D. Brault, Shaoyi Jiang
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Publication number: 20140303400Abstract: A process for the complete or partial oxygenation of hydrocarbons comprises contacting a C1-C8 hydrocarbon, molecular oxygen, and hydrogen peroxide, in the presence of water and a heterogeneous catalyst, under conditions suitable to convert the C1-C8 hydrocarbon to at least one corresponding C1-C8 oxygenate product, wherein the heterogeneous catalyst provides confinement and contains both Brønsted-Lowry acid centers and Lewis acid centers. The reaction may be carried out at a temperature ranging from 2° C. to 90° C. The use of molecular oxygen increases the economic attractiveness of the process while also improving yield.Type: ApplicationFiled: October 3, 2012Publication date: October 9, 2014Applicant: UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITEDInventors: Graham J. Hutchings, Michael M. Forde, Jose A. Lopez - Sanchez, Nikolaos Dimitratos
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Patent number: 8784285Abstract: A wearable harness system for exercise including an elastic waistband, a harness assembly, swivel strap assemblies, fixed strap assemblies and elastic bands. At least one elastic band is engaged to the loops of gloves and/or footwear. The elastic waistband adjusts around a user's body. The fixed strap and the swivel strap assemblies mount upon the lower and upper corners, respectively, of the harness assembly. Each swivel strap assembly comprises a base plate and an exterior plate with first and second edges disposed at predetermined angles. Between the base plate and the exterior plate is a strap assembly with a loop. A pin passes through the central holes of the base plate, the exterior plate and the strap assembly. Threads secure the base plate and the exterior plate to the harness assembly and the elastic band. The strap assemblies may rotate from a vertical to a horizontal position.Type: GrantFiled: April 11, 2012Date of Patent: July 22, 2014Inventors: Jose A. Lopez, Liliana Leal Rivera
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Publication number: 20130178537Abstract: Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).Type: ApplicationFiled: July 6, 2012Publication date: July 11, 2013Applicant: Probelte Pharma, S.A.Inventors: Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Penalver Mellado, Pedro Martinez Ortiz
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Patent number: D948951Type: GrantFiled: December 23, 2019Date of Patent: April 19, 2022Inventor: Jose A. Lopez