Patents by Inventor Jose Alberto Orfao De Matos Correia E Vale
Jose Alberto Orfao De Matos Correia E Vale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11571457Abstract: The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ?8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10?4, even down to 10?5. Also provided are diagnostic kits and methods for detecting MRD.Type: GrantFiled: October 30, 2020Date of Patent: February 7, 2023Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes Van der Velden, Sebastian Böttcher, Anthonie Willem Langerak, Ester Mejst{hacek over (r)}íková, Tomasz Szczepański, Matthias Ritgen, Paulo Jorge Monteiro Da Silva Lucio
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Publication number: 20220390457Abstract: The invention relates to the field of diagnostic immunology. Provided are means and methods for multiparameter cytometry-based leukocyte subsetting, which is advantageously used for the monitoring of the immune status of a subject, and/or for monitoring the effects of an immune modulatory treatment. Provided among others is a reagent composition comprising antibodies conjugated to a detectable label, the conjugated antibodies being directed against the following combination of markers: CD141, HLA-DR, CD16, CD33, CD300e, CD303 and CD14, wherein the antibodies directed against CD300e and CD303 may be conjugated to the same label.Type: ApplicationFiled: November 5, 2020Publication date: December 8, 2022Inventors: Jacobus Johannes Maria Van Dongen, José Alberto Orfao De Matos Correia E Vale, Cristina Isabel Gonçalves Grunho Teodósio, Martín Pérez Y Andrés, Julia Maria Almeida Parra, Wouter Bernard Louis Van Den Bossche, Vitor Dessanti Botafogo Goncalves, Magdalena Agnieszka Berkowska, Kyra Van Der Pan, Elena Blanco Álvarez, Annieck Margo Diks, Daniela Pinto Damasceno, Alejandro Hernández Delgado
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Patent number: 11442060Abstract: The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.Type: GrantFiled: January 14, 2020Date of Patent: September 13, 2022Assignees: Erasmus University Medical Center Rotterdam, Universidad De SalamancaInventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale
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Publication number: 20210263017Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: March 8, 2021Publication date: August 26, 2021Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Martín Ayuso, Carlos Eduardo Pedreira
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Publication number: 20210177936Abstract: The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ?8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10?4, even down to 10?5. Also provided are diagnostic kits and methods for detecting MRD.Type: ApplicationFiled: October 30, 2020Publication date: June 17, 2021Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes Van der Velden, Sebastian Böttcher, Anthonie Willem Langerak, Ester Mejstríková, Tomasz Szczepanski, Matthias Ritgen, Paulo Jorge Monteiro Da Silva Lucio
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Publication number: 20210080460Abstract: This invention relates to the field of primary immunodeficiencies (PID), more specifically to means and method for the diagnosis of PID of the lymphoid system. Provided are unique reagent compositions for the flow cytometric immunophenotyping of leukocytes comprising fluorochrome-conjugated antibodies directed against various specific combinations of markers. Also provided are kits comprising the reagent compositions, and methods using the same.Type: ApplicationFiled: September 24, 2020Publication date: March 18, 2021Inventors: Jacobus Johannes Maria VAN DONGEN, José Alberto ORFAO DE MATOS CORREIA E VALE, Mirjam VAN DER BURG, Martín PÉREZ-ANDRÉS, Menno Cornelis VAN ZELM, Tomás KALINA, Marcela VLKOVÁ, Eduardo LÓPEZ-GRANADOS, Elena BLANCO ÁLVAREZ, Anne-Kathrin KIENZLER
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Patent number: 10942172Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: GrantFiled: December 20, 2017Date of Patent: March 9, 2021Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstrikova, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Martin Ayuso, Carlos Eduardo Pedreira
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Patent number: 10942171Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: GrantFiled: December 20, 2017Date of Patent: March 9, 2021Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstrikova, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Martín Ayuso, Carlos Eduardo Pedreira
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Patent number: 10874710Abstract: The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ?8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10?4, even down to 10?5. Also provided are diagnostic kits and methods for detecting MRD.Type: GrantFiled: November 14, 2017Date of Patent: December 29, 2020Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes Van der Velden, Sebastian Böttcher, Anthonie Willem Langerak, Ester Mejst{hacek over (r)}íková, Tomasz Szczepański, Matthias Ritgen, Paulo Jorge Monteiro Da Silva Lucio
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Patent number: 10802023Abstract: This invention relates to the field of primary immunodeficiencies (PID), more specifically to means and method for the diagnosis of PID of the lymphoid system. Provided are unique reagent compositions for the flow cytometric immunophenotyping of leukocytes comprising fluorochrome-conjugated antibodies directed against various specific combinations of markers. Also provided are kits comprising the reagent compositions, and methods using the same.Type: GrantFiled: October 30, 2015Date of Patent: October 13, 2020Assignee: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAMInventors: Jacobus Johannes Maria Van Dongen, José Alberto Orfao De Matos Correia E Vale, Mirjam Van Der Burg, Martin Pérez-Andrés, Menno Cornelis Van Zelm, Tomá{hacek over (s)} Kalina, Marcela Vlková, Eduardo López-Granados, Elena Blanco Álvarez, Anne-Kathrin Kienzler
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Publication number: 20200191777Abstract: The invention relates to the field of medical diagnostics. Provided are methods and kits for determining the health status of a subject, for early detection of tissue damage, for early diagnosis and monitoring of a disease, and/or for evaluation of treatment effectiveness in a subject using circulating tissue macrophages (CTM) as a mirror of disrupted tissue homeostasis and disease.Type: ApplicationFiled: January 14, 2020Publication date: June 18, 2020Inventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale
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Patent number: 10209245Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: GrantFiled: December 20, 2017Date of Patent: February 19, 2019Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria van Dongen, Jose Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstrikova, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Martín Ayuso, Carlos Eduardo Pedreira
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Patent number: 10133962Abstract: The invention relates to a computer-implemented method for classifying events present in a sample, wherein each event is characterized by a multidimensional set of parameters obtained by means of hardware and/or software, wherein the values of the parameters associated with each event define the position coordinates of said event in a multidimensional space. Said method comprises the following stages: a) clustering the events in groups, b) checking if within each formed group there is a connection between events exceeding a maximum distance threshold, c) calculating the affinity between each pair of previously generated sample groups, d) comparing each sample group with at least one reference group stored in at least one database, e) classifying the sample groups based on the comparisons with the reference groups.Type: GrantFiled: June 9, 2017Date of Patent: November 20, 2018Assignees: Cytognos, S.L., Universidad de SalamancaInventors: Rafael Fluxá Rodriguez, José Alberto Orfao de Matos Correia E Vale, Juan Bernardo Hernández Herrero
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Publication number: 20180181835Abstract: The invention relates to a computer-implemented method for classifying events present in a sample, wherein each event is characterized by a multidimensional set of parameters obtained by means of hardware and/or software, wherein the values of the parameters associated with each event define the position coordinates of said event in a multidimensional space. Said method comprises the following stages: a) clustering the events in groups, b) checking if within each formed group there is a connection between events exceeding a maximum distance threshold, c) calculating the affinity between each pair of previously generated sample groups, d) comparing each sample group with at least one reference group stored in at least one database, e) classifying the sample groups based on the comparisons with the reference groups.Type: ApplicationFiled: June 9, 2017Publication date: June 28, 2018Inventors: Rafael Fluxá Rodríguez, José Alberto Orfao de Matos Correia E Vale, Juan Bernardo Hernández Herrero
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Publication number: 20180180597Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: December 20, 2017Publication date: June 28, 2018Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marin Ayuso, Carlos Eduardo Pedreira
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Publication number: 20180180598Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: December 20, 2017Publication date: June 28, 2018Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marin Ayuso, Carlos Eduardo Pedreira
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Publication number: 20180140664Abstract: The invention relates to the field of minimal residual disease (MRD) diagnostics, which is progressively more applied for the evaluation of treatment effectiveness in patients with a hematological malignancy, such as B-cell precursor acute lymphoblastic leukemia (BCP-ALL), B-cell chronic lymphocytic leukemia (B-CLL), and multiple myeloma (MM). Provided are unique reagent compositions with carefully selected and thoroughly tested combinations of antibodies, for ?8-color flow cytometric stainings as well as for 10-color and 12-color flow cyometric stainings, which can reach sensitivities of at least 10?4, even down to 10?5. Also provided are diagnostic kits and methods for detecting MRD.Type: ApplicationFiled: November 14, 2017Publication date: May 24, 2018Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes Van der Velden, Sebastian Böttcher, Anthonie Willem Langerak, Ester Mejstriková, Tomasz Szczepanski, Matthias Ritgen, Paulo Jorge Monteiro Da Silva Lucio
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Publication number: 20180120301Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least there identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: ApplicationFiled: December 20, 2017Publication date: May 3, 2018Inventors: Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes van der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary de Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marin Ayuso, Carlos Eduardo Pedreira
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Patent number: 9880158Abstract: The invention relates to the field of flow cytometry and more particularly to a panel of antibody reagents conjugated to fluorescent compounds. Provided are reagent compositions, comprising at least eight distinct fluorochrome-conjugated antibodies comprising a set of at least three identification antibodies for the identification of a leukocyte population of interest and at least four characterization antibodies for further characterization and/or classification of said leukocyte population. Also provided are kits and methods related to the reagent compositions.Type: GrantFiled: June 2, 2010Date of Patent: January 30, 2018Assignee: Erasmus University Medical Center RotterdamInventors: Jacobus Johannes Maria Van Dongen, José Alberto Orfao De Matos Correia E Vale, Juan Alejandro Flores-Montero, Julia Maria Almeida Parra, Vincent Henricus Johannes Van Der Velden, Sebastian Böttcher, Andrew Craig Rawstron, Ruth Mary De Tute, Ludovic Bernard Simon Lhermitte, Vahid Asnafi, Ester Mejstríková, Tomasz Szczepanski, Paulo Jorge Monteiro Da Silva Lucio, Marta Marín Ayuso, Carlos Eduardo Pedreira
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Patent number: 9823248Abstract: The invention relates to the field of medical diagnostics. In particular, it relates method and kits for identification and classification of IgE-related diseases, e.g. Type I hypersensitivity, as well as for monitoring of treatment efficacy, for instance anti-IgE therapy.Type: GrantFiled: November 15, 2011Date of Patent: November 21, 2017Assignees: ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM, UNIERSIDAD DE SALAMANCAInventors: Menno Cornelis van Zelm, Jacobus Johannes Maria van Dongen, José Alberto Orfao de Matos Correia e Vale