Abstract: Use of organic compounds for the treatment of the infection caused by human immunodeficiency virus type 1 (HIV-1), as well as other diseases caused by RNA viruses is disclosed.

Abstract: The invention relates to novel bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to their ability to interact with an internal RNA loop and to mimic a protein ?-helix these compounds are effective in the treatment and/or prevention of HIV-1 (Human Immunodeficiency Virus-1) infection and other diseases such as those caused by other RNA viruses and by gram-positive and gram-negative bacteria, or infectious or chronic diseases responsive to inhibition of DNA transcription, or infectious or chronic diseases where these compounds can be used to modulate the function of RNA internal loops, or infectious or chronic diseases where these compounds can be used as agonists or inhibitors of ?-helical proteins in interaction with other biomolecules.

Abstract: The present invention is directed to a topical pharmaceutical composition which comprises a compound of formula (I), such as hydroxytyrosol, or a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof, and a pharmaceutically acceptable carrier wherein R1, R2 and R3 take different values, and the use of said composition as 10 medicament in the prevention of sexually transmitted diseases (STDs), such as HIV-infection.

Abstract: The present invention refers to HIV-based recombinant viral clones that possess the general structure represented in FIG. 8 and are the result of the following genetic manipulations: deletion of HIV fragments (for example, Nef gene) without losing infective capacity, insertion of a non-expressed gene in human cells, insertion of LacZ gene, introduction of restriction sites for extracting DNA fragments of matrix provirus and substituting them for genes from patients to assess. The present invention also refers to the application of these clones in analytical methods related to AIDS.

Abstract: The present invention refers to HIV-based recombinant viral clones that possess the general structure represented in FIG. 8 and are the result of the following genetic manipulations: deletion of HIV fragments (for example, Nef gene) without losing infective capacity, insertion of a non-expressed gene in human cells, insertion of LacZ gene, introduction of restriction sites for extracting DNA fragments of matrix provirus and substituting them for genes from patients to assess. The present invention also refers to the application of these clones in analytical methods related to AIDS.