Patents by Inventor Jose Amato

Jose Amato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10343984
    Abstract: The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N?-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: July 9, 2019
    Assignee: CHEMO RESEARCH. S.L.
    Inventor: José Amato
  • Publication number: 20180244608
    Abstract: The present invention relates to a process for the preparation of the compound N-(3,5-dimethylphenyl)-N?-(2-trifluoromethylphenyl) guanidine of formula (I) which comprises reacting a salt of a compound of formula (II) or a mixture of the salt of the compound of formula (II) and a compound of formula (II) with a compound of formula (III), in the presence of a polar organic solvent; a crystalline solid form of the compound of formula (I), in particular crystalline solid form A; to a pharmaceutical composition comprising them; and to their use as a medicament, in particular to the treatment of a condition mediated by Rho-GTPase cell proteins.
    Type: Application
    Filed: August 10, 2016
    Publication date: August 30, 2018
    Inventor: José AMATO
  • Patent number: 4036985
    Abstract: The present invention relates to new 2-mono substituted malonic acid diamides. Furthermore, the invention relates to a process of preparing these compounds. Also the invention relates to a pharmaceutical composition including as an active antiinflammatory-analgesic-antipyretic agent compound according to the invention and methods of treating with the new compounds and compositions, warm blooded animals.
    Type: Grant
    Filed: July 16, 1975
    Date of Patent: July 19, 1977
    Inventors: Jose Amato, Marta Propker, Magdalena Julia Beatriz Pongracz, Jorge Luis Jose Szabo