Patents by Inventor Jose Antonio ORTEGA MARTINEZ

Jose Antonio ORTEGA MARTINEZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 1,3,5-triazines as inhibitors for a rho family of GTP-ases
    Patent number: 11952366
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: April 9, 2024
    Assignees: Fondazione Istituto Italiano Di Tecnologia
    Inventors: Marco De Vivo, Anand Ganesan, Jose Antonio Ortega Martinez, Sohail Jahid
  • COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF TUMORS
    Publication number: 20230052747
    Abstract: The present invention relates to compounds of Formula (Ia) or pharmaceutically acceptable salts, hydrates, solvates, clathrates, polymorphs, stereoisomers thereof. It further discloses a pharmaceutical composition comprising compounds of Formula (Ia) and the use of compounds of Formula (Ib), in particular for the use in the treatment of diseases or disorders wherein disrupting Rad51-BRCA2 interaction is beneficial.
    Type: Application
    Filed: December 11, 2020
    Publication date: February 16, 2023
    Inventors: Andrea Cavalli, Domenico Milano, Marcella Manerba, Greta Bagnolini, Jose Antonio Ortega Martinez, Marinella Roberti, Giuseppina Di Stefano, Roberto Pellicciari, Francesca De Franco, Saverio Minucci, Pier Giuseppe Pelicci, Viola Previtali
  • Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies
    Publication number: 20220242848
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.
    Type: Application
    Filed: November 23, 2021
    Publication date: August 4, 2022
    Applicants: Fondazione Istituto Italiano Di Tecnologia, The Regents of the University of California
    Inventors: Marco De Vivo, Anand Ganesan, Jose Antonio Ortega Martinez, Sohail Jahid
  • MODULATORS OF INTRACELLULAR CHLORIDE CONCENTRATION
    Publication number: 20220184008
    Abstract: The present invention relates to a compound of Formula la, lb and Ic, (Formula Ia) a pharmaceutical composition comprising the same and their use in the treatment or prevention of pathological conditions associated to depolarizing GABAergic transmission including, for example, Down syndrome and autism.
    Type: Application
    Filed: April 2, 2020
    Publication date: June 16, 2022
    Inventors: Laura Cancedda, Marco De Vivo, Andrea Contestabile, Marco Borgogno, Annalisa Savardi, Jose Antonio Ortega Martinez
  • Substituted pyrimidines as inhibitors for a Rho family of GTP-ases
    Patent number: 11198682
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: December 14, 2021
    Assignees: Fondazione Istituto Italiano Di Tecnologia, The Regents of the University of California
    Inventors: Marco De Vivo, Anand Ganesan, Jose Antonio Ortega Martinez, Sohail Jahid
  • 4-amino-2-pyrido-bicyclic pyrimidines and use thereof as topoisomerase II inhibitors
    Patent number: 10889560
    Abstract: The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines of Formula (I) that function as type II topoisomerase inhibitors and their use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines of Formula (I).
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: January 12, 2021
    Assignees: UNIVERSITÀ DEGLI STUDI DI PADOVA, ALMA MATER STUDIORUM-UNIVERSITÀ DI BOLOGNA, FONDAZIONE ISTITUTO ITALIANO DI TECHNOLOGIA
    Inventors: Marco De Vivo, Jose Antonio Ortega Martinez, Jose Manuel Arencibia Jimenez, Anna Minarini, Claudia Sissi
  • Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies
    Publication number: 20200062733
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.
    Type: Application
    Filed: May 2, 2018
    Publication date: February 27, 2020
    Applicants: Fondazione Istituto Italiano Di Tecnologia, The Regents of the University of California
    Inventors: Marco De Vivo, Anand Ganesan, Jose Antonio Ortega Martinez, Sohail Jahid
  • 4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS
    Publication number: 20190315709
    Abstract: The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines as type II topoisomerase inhibitors and use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines.
    Type: Application
    Filed: December 15, 2017
    Publication date: October 17, 2019
    Inventors: Marco DE VIVO, Jose Antonio ORTEGA MARTINEZ, Jose Manuel ARENCIBIA JIMENEZ, Anna MINARINI, Claudia SISSI