Abstract: The disclosure relates to topical compositions and methods comprising whole, non-viable Micrococcaceae cells, wherein the cells have been processed to kill the cells while minimizing lysis. The topical compositions and methods are useful for decreasing skin inflammation and improving skin barrier function.

Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO by providing a composition comprising a compound set forth in Formula (I):

Abstract: The invention provides one or more methods of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.

Abstract: The invention provides a method of inhibiting the conversion of carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual one or more compositions comprising a compound set forth in Formula (I): Wherein the compound is administered in an amount effective to inhibit conversion of carnitine to TMA in the individual.

Abstract: The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I): The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.

Abstract: A formulation comprising an ingestible carrier and an isolated strain of Bifidobacterium longum.

Abstract: The disclosure relates to topical compositions and methods comprising whole, non-viable Micrococcaceae cells, wherein the cells have been processed to kill the cells while minimizing lysis. The topical compositions and methods are useful for decreasing skin inflammation and improving skin barrier function.

Abstract: Protective antigens against infestations with Ixodes spp. ticks, gene sequences and encoded proteins for such antigens, related vaccines and methods useful to induce an immune response, which are protective to interfere with infestations by Ixodes spp. ticks are presented.

Abstract: Vaccines and methods for inducing an immune response in a ruminant. The vaccine composition including pathogen and tick-derived antigens and a carrier or diluent. The method for inducing an immune response in a ruminate to provide immune protection which reduces the infection of ticks by A. marginale and/or prevents the transmission of the pathogen includes the steps of administering to the ruminant an effective amount of the vaccine composition having at least one antigen member of the group comprising at least one antigen member of the group comprising (i) recombinant MSP1a surface protein antigen of A. marginale, (ii) a subunit of recombinant MSP1a surface protein antigen of A. marginale and (iii) recombinant MSP1a surface protein antigen or subunits thereof in combination with antigen preparation derived from A. marginale infected cultured tick IDE8 cells and/or other pathogen and tick-derived antigens, and a carrier or diluent.

Abstract: B-cell epitopes in the N-terminal repeated peptides of Anaplasma marginale major surface protein (MSP)1a are characterized. Pharmaceutical compositions including such epitopes, and methods useful to induce or enhance an immune response against infection by ehrlichial parasites of the species Anaplasma marginale, are provided.

Abstract: Vaccines and methods useful to induce an immune response which is protective to reduce the severity or prevent infection by ehrlichial parasites of the species Anaplasma marginale utilizing recombinant MSP1a surface protein antigens alone or in combination with tick cell culture derived A. marginale.

Abstract: Protective antigens against infestations with Ixodes spp. ticks, gene sequences and encoded proteins for such antigens, related vaccines and methods useful to induce an immune response, which are protective to interfere with infestations by Ixodes spp. ticks.

Abstract: Vaccines and methods useful to induce an immune response which is protective to reduce the severity or prevent infection by ehrlichial parasites of the species Anaplasma marginale utilizing recombinant MSP1a surface protein antigens alone or in combination with tick cell culture derived A. marginale.