Abstract: An injectable pharmaceutical composition contained in a receptacle for injection into a human, which comprises a solution of zoledronic acid or the salts thereof, a solvent and a pH regulator.

Abstract: A catheter having features configured to provide a substantially uniform flow rate of a fluid exiting the catheter and also exhibits anti-microbial properties. The uniform flow rate features may include one or more of a flow restricting membrane or flow restricting component within an infusion section of the catheter. In other arrangements, exit holes defining the infusion section of the catheter may be configured to provide the desired uniform flow rate over the length of the infusion section. Furthermore, the catheter also includes anti-microbial properties to inhibit the growth of microbes on or within the catheter and, preferably, to inhibit microbe growth in an anatomical region surrounding the catheter. The desired anti-microbial properties may be provided by an anti-microbial layer, anti-microbial materials dispersed within the material from which components of the catheters are constructed, or a combination of anti-microbial layers and embedded anti-microbial materials.

Abstract: Flexible bag includes at least a first wall, a second wall facing the first wall when the flexible bag is folded and a functional part having at least a portion protruding from the first wall inside the bag. The second wall includes protective means intended to prevent damage to the flexible bag and/or to the functional part.

Abstract: Mixing system comprising: a flexible bag with a mixing device comprising a magnetic impeller; and an alignment facilitation device adapted to facilitate alignment between the magnetic impeller and a magnetic driver located external to the system. Specific flexible bag and hardware therefore.

Abstract: The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with some embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube and an elongated member positioned within the tube. The exit holes combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region.

Abstract: A catheter is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter is comprised of an elongate tubular catheter body defining a lumen. A distal end of the lumen is closed and a portion of the catheter body includes a plurality of openings thereby defining an infusion section of the catheter. A tubular sheath is constructed from a porous material and is positioned over the infusion section. The tubular sheath extends at least a length of the infusion section. The tubular sheath and the catheter body are configured such that fluid within the lumen must pass through the tubular sheath to exit the catheter. In at least one embodiment, a pore size of the porous material is less than about 0.5 microns.

Abstract: The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with some embodiments, the catheter includes an elongated tubular member made of a porous membrane. The porous membrane is configured so that a fluid introduced into an open end of the tubular member will flow through side walls of the tubular member at a substantially uniform rate along a length of the tubular member. In accordance with other embodiments, the catheter includes an elongated “weeping” tubular coil spring attached to an end of, or enclosed within, a tube. Fluid within the spring and greater than or equal to a threshold pressure advantageously flows radially outward between the spring coils. Advantageously, the fluid is dispensed substantially uniformly throughout a length of the spring. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube.

Abstract: The present invention relates to a cell culture device (1) comprising a disposable culture vessel comprising at least one external wall made of a material having a Young modulus E of less than 50 GPa, in which there is situated at least one cell culture zone and at least one cell-free medium transfer zone, allowing a flow of a culture medium between the cell culture zone and the transfer zone, and at least one sensor element of a cell-density sensor wherein said sensor element is situated in the cell culture zone of said vessel. The sensor element is an electrode arrangement of at least two and preferably at least four measuring electrodes arranged on the inner side of an external wall of the disposable culture vessel and directed towards the cell culture zone. The present invention further relates to a method of culturing cells.

Abstract: The invention relates to a method including spraying steam in the form of multiple jets with a pressure and a temperature depending on the characteristics of the solar panel to be cleaned and of the impurities to be removed and at an angle that can be adjusted relative to the panel. The method can be combined with gentle cleaning using elements contacting the surface of the panels to be cleaned. The device includes a self-propelled vehicle, a water tank feeding a system for treating and purifying the water prior to feeding a steam generator, with a means for regulating the output temperature and pressure of the steam, which enters a system for distribution to the steam diffusers, which are coupled on a support associated with a cantilevered structure of the self-propelled vehicle.

Abstract: A catheter is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter is compromised of an elongated, proximal tube defining a lumen and an elongated, distal tube having a closed end. The distal tube is constructed from a bio-absorbable material and also defines a lumen, which communicates with the lumen of the proximal tube. In one embodiment, at least a portion of the distal tube defines a porous side wall that permits fluid within the lumen to pass through the portion of the distal tube. In another embodiment, the proximal tube and the distal tube overlap one another and are secured to one another at the overlapping surfaces.

Abstract: Flexible bag comprising at least a first wall, a second wall facing the first wall when the flexible bag is folded and a functional part having at least a portion protruding from the first wall inside the bag, wherein the second wall comprises protective means intended to prevent damage to said flexible bag and/or to said functional part.

Abstract: The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with one embodiment, the catheter comprises an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region. In one particular embodiment, the catheter comprises a tube having elongated exit slots therein. In accordance with other embodiments, the catheter includes an elongated tubular member made of a porous membrane.

Abstract: A disposable material processing apparatus, useable as a bioreactor or fermenter, includes a hollow tank (101) and a mixing paddle (110) disposed within the interior of the tank and adapted to mix contents therein. The paddle may be isolated within a flexible sleeve (140). Various functional elements, such as a sparger, sensor, material extraction conduit, material addition conduit, and/or heat exchange element may be provided, and optionally arranged to travel with the paddle within the tank interior. Baffles may protrude into a mixing tank to enhance mixing. A tank and/or sleeve may comprise polymeric film materials.

Abstract: Catheters for uniform delivery of medication within an anatomical region. A catheter includes an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. A catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. A catheter includes an elongated tubular member made of a porous membrane. The porous membrane is configured so that a fluid introduced into an open end of the tubular member will flow through side walls of the tubular member at a substantially uniform rate along a length of the tubular member. A catheter includes an elongated “weeping” tubular coil spring attached to an end of, or enclosed within, a tube.

Abstract: The present invention relates to methods for the diagnosis and evaluation of stroke and stroke sub-type. A variety of bio-markers are disclosed for assembling a panel for such diagnosis and evaluation. Methods are disclosed for selecting markers and correlating their combined levels with a clinical outcome of interest. In various aspects: the invention provides methods for early detection and differentiation of stroke subtypes, for determining the prognosis of a patient presenting with stroke symptoms, and identifying a patient at risk for hemorrhagic transformation after thrombolyic therapy. Methods are disclosed that provide rapid, sensitive and specific assays to greatly increase the number of patients that can receive beneficial stroke treatment and therapy, and reduce the costs associated with incorrect stroke diagnosis.

Abstract: Mixing system comprising: a flexible bag with a mixing device comprising a magnetic impeller; and an alignment facilitation device adapted to facilitate alignment between the magnetic impeller and a magnetic driver located external to the system. Specific flexible bag and hardware therefore.

Abstract: The present invention provides a catheter for the delivery of fluid medication across an anatomical region. In accordance with one embodiment, the catheter comprises an elongated tube with a plurality of exit holes along an infusion section of the catheter, and an elongated flexible porous member residing within the tube and forming an annular space between the tube and the member. In accordance with other embodiments, the catheter includes a tube having a plurality of exit holes in a side wall of the tube. The exit holes may combine to form a flow-restricting orifice of the catheter. Advantageously, fluid within the catheter flows through all of the exit holes, resulting in uniform distribution of fluid within an anatomical region. In one particular embodiment, the catheter comprises a tube having elongated exit slots therein. In accordance with other embodiments, the catheter includes an elongated tubular member made of a porous membrane.

Abstract: A catheter having features configured to provide a substantially uniform flow rate of a fluid exiting the catheter and also exhibits anti-microbial properties. The uniform flow rate features may include one or more of a flow restricting membrane or flow restricting component within an infusion section of the catheter. In other arrangements, exit holes defining the infusion section of the catheter may be configured to provide the desired uniform flow rate over the length of the infusion section. Furthermore, the catheter also includes anti-microbial properties to inhibit the growth of microbes on or within the catheter and, preferably, to inhibit microbe growth in an anatomical region surrounding the catheter. The desired anti-microbial properties may be provided by an anti-microbial layer, anti-microbial materials dispersed within the material from which components of the catheters are constructed, or a combination of anti-microbial layers and embedded anti-microbial materials.

Abstract: A catheter is provided for uniform distribution of fluid medication within an anatomical region. One embodiment of the catheter is comprised of an elongate tubular catheter body defining a lumen. A distal end of the lumen is closed and a portion of the catheter body includes a plurality of openings thereby defining an infusion section of the catheter. A tubular sheath is constructed from a porous material and is positioned over the infusion section. The tubular sheath extends at least a length of the infusion section. The tubular sheath and the catheter body are configured such that fluid within the lumen must pass through the tubular sheath to exit the catheter. In at least one embodiment, a pore size of the porous material is less than about 0.5 microns.

Abstract: A catheter having features configured to provide a substantially uniform flow rate of a fluid exiting the catheter and also exhibits anti-microbial properties. The uniform flow rate features may include one or more of a flow restricting membrane or flow restricting component within an infusion section of the catheter. In other arrangements, exit holes defining the infusion section of the catheter may be configured to provide the desired uniform flow rate over the length of the infusion section. Furthermore, the catheter also includes anti-microbial properties to inhibit the growth of microbes on or within the catheter and, preferably, to inhibit microbe growth in an anatomical region surrounding the catheter. The desired anti-microbial properties may be provided by an anti-microbial layer, anti-microbial materials dispersed within the material from which components of the catheters are constructed, or a combination of anti-microbial layers and embedded anti-microbial materials.