Abstract: A method of rapidly analyzing unexpected metabolites in a metabolite analyzing system is disclosed. A control sample is run and analyzed to generate an exclusion list of unwanted sample components. A single analyte sample is then run and programmatically uses the exclusion list containing the unwanted metabolites to dynamically filter out data regarding components present in both the control sample and the analyte sample. The remaining components in the analyte sample are analyzed for unexpected metabolites of interest. The present invention allows for the analysis to be automated and eliminates the need for a second analyte sample run for the purpose of eliminating common components in the samples.

Abstract: Compounds of formula I: are potent and selective antagonists of the human 5-HT2A receptor, and hence useful in treatment of a variety of adverse conditions of the CNS.

Abstract: A class of 8-fluoroimidazo[1,2-?]pyridine derivatives, substituted at the 3-position by an optionally substituted five-membered or six-membered heteroaromatic ring, being selective ligands for GABAA receptors, in particular having high affinity for the ?2 and/or ?3 and/or ?5 subunit thereof, are accordingly of benefit in the treatment and/or prevention of adverse conditions of the central nervous system, including anxiety, convulsions and cognitive disorders.

Abstract: The present invention discloses a compound of formula I, or a pharmaceutically acceptable salt thereof: (I) wherein —U—V— represents —CH?CH—, or —CH2—CH2—, —N?CH— or —CH?N—; X1 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy; X2 represents hydrogen or halogen; Y represents a chemical bond, an oxygen atom, or a —NH— or —OCH2— linkage; Z represents an optionally substituted aryl or heteroaryl group; R1 represents hydrocarbon, a heterocyclic group, trifluoromethyl, —SO2Ra, —SO2NRaRb, —CORa, —CO2Ra or —CONRaRb; and Ra and Rb independently represent hydrogen, hydrocarbon or a heterocyclic group; pharmaceutical compositions comprising it; its use in methods of treatment; use of it in the manufacture of a medicament for treating and/or preventing anxiety; convulsions or a cognitive disorder; and methods of treatment using it.

Abstract: A numerical method operating within a processor-based environment for predicting the fill pattern and coating pressure distribution for a substrate in a computer simulation of an in-mold coating flow within a two-dimensional flow domain having a plurality of possible inlet nodes for injection, which includes the steps of initializing pressure and thickness change of the substrate for at least one of the inlet nodes, determining which of the inlet nodes are newly filled nodes and new flow front nodes, calculating pressure for the newly filled nodes; updating thickness and coating volume of the substrate, checking if pressure and time step have converged, and updating pressure and time step and returning to the pressure calculation step if pressure and time step calculations have not converged, and determining whether the substrate is filled, and updating filling time and returning to the determining step if the substrate is not filled.

Abstract: Compounds of formula I: inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease.

Abstract: The present invention provides a method and system of anticipating salt depletion in a brine tank of a water softener system, the system including a controller having a user interface and display, the method comprising the steps of tracking salt usage; determining the amount of salt remaining in the brine tank; calculating the number of days before salt is required in the brine tank based on salt usage and the amount of salt remaining in the brine tank; and providing an indication of the number of days to empty, whereby a user is able to anticipate the need to replenish the salt supply and plan accordingly to assure continuous satisfactory operation of the water softener system.

Abstract: The present invention provides a method and system of anticipating salt depletion in a brine tank of a water softener system, the system including a controller having a user interface and display, the method comprising the steps of tracking salt usage; determining the amount of salt remaining in the brine tank; calculating the number of days before salt is required in the brine tank based on salt usage and the amount of salt remaining in the brine tank; and providing an indication of the number of days to empty, whereby a user is able to anticipate the need to replenish the salt supply and plan accordingly to assure continuous satisfactory operation of the water softener system.

Abstract: A collapsible and concealable stand or pulpet for holding a device such as a cellular phone handset or an electronic map within arm's reach of an automotive vehicle driver, comprises a cradle or platform supported by an articulated or flexible arm that is secured by a rotating and swiveling joint to the floor of the vehicle or to a seat anchoring bracket. The stand can be folded down and rotated in a horizontal plane to place the device out of sight under the driver's or passenger's seat.

Abstract: An improved apron and apron drive mechanism for object or patient transferring apparatus of the type in which different phases of transfer operation are effected by selective linear travel in a transfer apron. The transfer apron to carry out the transfer operation in conjunction with a translatable separator plate is formed from a finite length of flexible belt material, the opposite ends of which are attached to winding rollers operated to pay out, take in or hold stationary apron flight portions in direct synchronism with a common drive shaft for translating the separator.