Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.

Abstract: The present invention refers to Imipramine for use as inhibitor of fascin1 overexpression, preferably said overexpression of fascin1 is associated to cancer, and more preferably to colorectal cancer. It also refers to a method for the treatment of cancer mediated by fascin1 comprising administering to a subject in need thereof an effective amount of imipramine, and more preferably to colorectal cancer.

Abstract: An identification device and procedure for pharmaceutical containers comprising at least one means of marking at least one secured identification code on each of the containers, characterised in that the device comprises at least one inkjet system configured to print the identification code on at least one surface of the moving container with at least one ink which exhibits visible fluorescence when radiated with ultraviolet (UV) radiation, and whose drying time is 1 to 3 seconds or less than about 3 seconds.

Abstract: An identification device and procedure for pharmaceutical containers comprising at least one means of marking at least one secured identification code on each of the containers, characterised in that the device comprises at least one inkjet system configured to print the identification code on at least one surface of the moving container with at least one ink which exhibits visible fluorescence when radiated with ultraviolet (UV) radiation, and whose drying time is 1 to 3 seconds or less than about 3 seconds.

Abstract: An apparatus to separate broken tablets comprising: a sieve plate having at least one perforation; a cover plate which is distanced from the sieve plate by an amount suitable to permit only broken tablets below a certain predetermined size to pass through the at least one perforation; and a vibrating device which vibrates the sieve plate.

Abstract: The invention relates to a process for transforming and managing messages from SIP signaling in an event-managed asynchronous system, comprising: receiving (S0, S0?, S0?) at least one SIP signaling message in an application server (1), extracting certain information relating to a call from said SIP message, creating/modifying (S1, S1?, S1?) a new/existing entry in a tree structure in which said information is stored, creating (S2) an asynchronous event from said information stored in the tree, sending (S4) said asynchronous event to an Event Distribution Module (20), and, assigning the control of said event to an application which wants to control said call (S8) or to the server (S9).