Patents by Inventor Jose Delamano Garcia

Jose Delamano Garcia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrrolo?3,2-E!indol derivatives, process for the preparation thereof and applications
    Patent number: 5786377
    Abstract: The pyrrolo?3,2-e! derivatives of the present invention have the formulae (I), (Ia) and (II) wherein R is substituted or unsubstituted aryl or heteroaryl, R' is substituted or unsubstituted alkanoyl, alkenoyl, alkynoyl, arenocarbonyl or heteroarenocarbonyl and X is chloro, bromo, iodo or alkylsulfonyl or arylsulfonyl. The compounds find utility as agents having antitumor activity, and are thus useful agents in the treatment of cancer.
    Type: Grant
    Filed: January 29, 1997
    Date of Patent: July 28, 1998
    Assignee: Universidad de Santiago de Compostela
    Inventors: Jose Delamano Garcia, Gabriel Tojo Suarez, Carmen Lopez Goti, Jesus Fernandez Almeida, Dolores Garcia Gravalos, Glynn Thomas Faircloth
  • Areno [e]indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity
    Patent number: 5631384
    Abstract: The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.
    Type: Grant
    Filed: July 3, 1996
    Date of Patent: May 20, 1997
    Assignee: Pharma-Mar, S.A.-Pharmar
    Inventors: Koen Alexander, Jose Delamano Garcia, Benedikt Sas, Gabriel Tojo Suarez, Dolores Garcia Gravalos
  • Areno [E]indols, preparation method and application as intermediates in the synthesis of products with antitumoral activity
    Patent number: 5571927
    Abstract: The areno[e]indols have the formula (I). The methods comprises: (a) reacting (VI) with an aldehyde Ar"--CHO to obtain (VII); (b) oxidizing (VII) to yield the cetone (VIII); (c) reating (VIII) with a strong base and thereafter with an acycle chloride ClCOR, to produce (IX); (d) subjecting to a photochemical cyclization (IX) to produce (I). In said formulas Ar is phenyl or substituted phenyl; Ar' is radical (i) or (ii); R is an acyle group, Ar" is a phenyl, pyrolyl, furanyl or thiophenyl group substituted up to three times by any of the radials R, R.sup.1, R.sup.2, or R.sup.3. The compounds (I) are useful as intermediates in the synthesis of hexahydroareno(e)cyclopropa(c)indol-4-ones with antitumoral activity.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: November 5, 1996
    Assignee: Pharma-Mar, S.A.- Pharmar
    Inventors: Koen Alexander, Jose Delamano Garcia, Benedikt Sas, Gabriel Tojo Suarez, Dolores Garcia Gravalos