Abstract: The present invention refers to the use of derivatives of 2,5-dihidroxybenzenosulphonic acids of general formula (I), to develop medicinal products of therapeutic value to enhance the effects of phosphodiesterase-5 including sildenaphyl, vardenaphyl and IC-351, of apomorphine, of nitric oxide donors including amyl nitrate, nitroglycerine, nitroprussiate, nitrosothioles and nicorandyl, of the compounds that increase the level of cyclic GMP in the penile tissue and of other compounds used to facilitate penile erection in man.

Abstract: The present invention relates to the use of 2,5-dihydroxybenzenesulfonic compounds for the manufacture of medicament for the regulation of nitric oxide (NO) synthesis and/or the regulation of EDHF (Endothelium-derived-Hyperpolarizing-Factor) in the endothelium of humans or animals, whereby the medicament is administered in a daily dose of the 2,5-dihydroxybenzenesulfonic compounds of formula I of <500 mg.

Abstract: The present invention relates to the use of 2,5-dihydroxybenzenesulfonic compounds for the manufacture of a medicament for the regulation of nitric oxide (NO) synthesis and/or the regulation of EDHF (Endothelium-Derived-Hyperpolarizing-Factor) in the endothelium of diabetic patients, whereby the medicament is administered in a daily dose of the 2,5-dihydroxybenzenesulfonic compounds of formula (I) of <500 mg.

Abstract: The present invention refers to the use of derivatives of 2,5-dihidroxybenzenosulphonic acids of general formula (I), to develop medicinal products of therapeutic value to enhance the effects of phosphodiesterase-5 including sildenaphyl, vardenaphyl and IC-351, of apomorphine, of nitric oxide donors including amyl nitrate, nitroglycerine, nitroprussiate, nitrosothioles and nicorandyl, of the compounds that increase the level of cyclic GMP in the penile tissue and of other compounds used to facilitate penile erection in man.

Abstract: A method for the use of 2,5-dihydroxybenzenesulfonic derivatives for normalizing endothelial function is disclosed. Preferred 2,5-dihydroxybenzenesulfonic derivatives are calcium dobesilate, ethamsylate and persilate.

Abstract: Method for the use of 2,5,-dihydroxybenzenesulphonic derivatives for normalizing endothelial function and treating sexual dysfunctions, the vascular complications of diabetes and vascualr disorders of endothelial origin are disclosed. Preferred 2,5-dihydroxybenzenesulponic derivatives are calcium dobesilate, ethamsylate and persilate.

Abstract: This invention relates to new derivatives of oxazinobenzothiazine-6,6-dioxide, to a process for the production thereof and to the use thereof as medicaments.The new derivatives according to the present invention correspond to the general formula I: ##STR1## wherein: R represents a linear or branched lower C.sub.1 -C.sub.4 alkyl radical, in particular the methyl and ethyl radicals,X represents an oxygen atom or a sulphur atom, andHet represents a mono- or bicyclic unsaturated heterocycle containing a nitrogen heteroatom in the ortho position relative to the link between the said heterocycle and the nitrogen atom of the oxazine ring, the said heterocycle optionally containing one or two other additional heteroatoms selected from nitrogen, oxygen and sulphur, and also being able to be substituted by one or two methyl radicals.

Abstract: The present invention relates to new derivatives of 7-(1-pyrrolyl)-1-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid and 7-(1-pyrrolyl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid of general formula I: ##STR1## in which: X represents a carbon atom or a nitrogen atom, andR represents a hydrogen atom or a fluorine atom, as well as their physiologicaly acceptable alkali metal salts or alkaline earth metal salts. The derivatives of the present invention are advantageously used as antimicrobial agents, espcially as anti-bacterial and anti-fungal agents.

Abstract: Calcium Dobesilate of the formula: ##STR1## Can be used against coronary heart disease, myocardial infarction or disturbances of the lymphatic circulation of the heart.

Abstract: Derivatives of p-chloroacetophenone oxime, the preparation thereof and the use thereof as medicaments.The compounds of the invention correspond to the general formula I ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl radical, preferably a C.sub.1 to C.sub.4 radical, or, in association with the nitrogen atom to which they are linked, form a saturated heterocyclic group, and the physiologically acceptable acid addition salts.The compounds of the invention are useful as medicaments and particularly as analgesics, antipyretics, anti-inflammatory agents and antitussives.

Abstract: Novel derivatives of formula (I) and the pharmaceutically acceptable salts thereof. ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached, form a saturated heterocyclic group optionally containing, in addition to the said nitrogen atom, a second hetero atom, a process for the preparation thereof, and their use as anti-histamine anti "H.sub.2 " agents.

Abstract: The invention relates to new salts of 2,5-dihydroxy benzene sulphonic acids and the process for their production.The new compounds according to the invention are salts corresponding to the general formula (I): ##STR1## in which M.sup.++ represents the divalent cation of a transition metal,N is the number 1 or 2, but with the proviso that, when n is the number 2, the two radicals --SO.sub.3.sup.- are situated in the para-position relative to one another.The new compounds are useful for treating disorders of the scalp.