Abstract: The present invention provides a photodynamic therapeutic method to shorten the infectivity period of an infection caused by a targeted microorganism comprising: applying a photosensitizer on a targeted body treatment area; and applying light to the targeted body treatment area at a wavelength absorbed by the photosensitizer. The present invention also provides a method to induce a sustained humoral and cellular T-Cell responses against an antigen of a targeted microorganism comprising: applying a photosensitizer on a targeted body treatment area; and applying light to the targeted body treatment area at a wavelength absorbed by the photosensitizer.

Abstract: A precision medicine system for patient management and rare disease identification can include an interface and a global data lake. The interface can be configured to search a plurality of search databases including medical data related to diagnosis or treatment plans. The global data lake can be configured to include a plurality of patient data lakes each storing patient data of at least one patient. The precision medicine system can further include a processor and a memory configured to label the patient data using medical ontologies and selectively produce relevant medical data from the search databases via the interface. The patient data can then be supplemented with the medical data. Embodiments enable clinicians to provide specialized, up to date diagnosis and treatment plants to patients by providing the clinicians with medical advancements specific to their patient.

Abstract: The present invention belongs to the field of biomedical chemistry and provides modified peptides and dimers thereof derived from the amino acid sequence of the protein ADAM-12, their compositions, process of synthesis and their use in medicine, specifically in the inhibition of cancer growth and/or the reduction or inhibition of cancer cell invasion and metastasis in different cancers.

Abstract: A machine, program product, and method for enabling interoperable and low-latency networking among service devices.

Abstract: A method of controlling a tight junction between epithelial cells of an animal comprises providing the animal with a feed containing polyphenols in an amount effective to increase transmembrane protein levels between the epithelial cells thereby minimizing passage of macromolecules between the epithelial cells of the animal.

Abstract: An on-axis aimer and distance measurement apparatus for a vision system can include a light source configured to generate a first light beam along a first axis. The first light beam can project an aimer pattern on an object and a receiver can be configured to receive reflected light from the first light beam to determine a distance between a lens of the vision system and the object. One or more parameters of vision system can be controlled based on the determined distance.

Abstract: This disclosure provides genetically engineered organisms with genetic modifications that are useful for producing desirable alkaloids. This disclosure also provides methods of making genetically engineered organisms that can produce desirable alkaloids. The organisms described herein produce alkaloids in amounts beyond that produced from comparable wild-type organisms. In certain embodiments, the genetically engineered organisms are fungi from the Basidiomycota division.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: Provided herein are methods for modulating the psilocybin biosynthesis pathway in fungi or other organisms. Also provided are genetically modified fungi and organisms with induced and/or increased expression of psilocybin and psilocin and psilocybin and/or psilocin compositions generated by the provided methods.

Abstract: A compact self-contained lighting system combining efficient LEDs with heat dissipating heat sinks, wherein the heat sinks are electrically connected to and provide power flow to the LEDs.

Abstract: This invention provides a system and method for detecting and acquiring one or more in-focus images of one or more barcodes within the field of view of an imaging device. A measurement process measures depth-of-field of barcode detection. A plurality of nominal coarse focus settings of a variable lens allow sampling, in steps, of a lens adjustment range corresponding to allowable distances between the one or more barcodes and the image sensor, so that a step size of the sampling is less than a fraction of the depth-of-field of barcode detection. An acquisition process acquires a nominal coarse focus image for each nominal coarse focus setting. A barcode detection process detects one or more barcode-like regions and respective likelihoods. A fine focus process fine-adjusts, for each high-likelihood barcode, the variable lens near a location of the barcode-like regions. The process acquires an image for decoding using the fine adjusted setting.

Abstract: Disclosed herein are novel compounds comprising antisense oligonucleotides that regulate the splicing of NUMB. In particular, an antisense oligonucleotide for reducing inclusion of NUMB exon 9 in a population of mature NUMB transcripts is provided. The antisense oligonucleotide comprises a sequence of at least 7 nucleotides that is complementary to a target region within exon 9 of a NUMB transcript. Pharmaceutical compositions comprising the antisense oligonucleotide and methods of treating a proliferative disease using the compounds or compositions of the invention are also described.

Abstract: An apparatus for controlling a depth of field for a reader in a vision system includes a dual aperture assembly having an inner region and an outer region. A first light source can be used to generate a light beam associated with the inner region and a second light source can be used to generate a light beam associated with the outer region. The depth of field of the reader can be controlled by selecting one of the first light source and second light source to illuminate an object to acquire an image of the object. The selection of the first light source or the second light source can be based on at least one parameter of the vision system.

Abstract: A process for the manufacturing of 3D reduced graphene oxide/Fe2O3 material includes the following steps: (i) putting in contact a graphene oxide (GO) water dispersion with an aqueous solution of iron(II) sulfate; (ii) hydrothermal treatment; and (iii) freezing the reaction product obtained in step (ii) at a temperature ??5° C.; and (iv) lyophilisation. A 3D reduced graphene oxide/Fe2O3 material is obtainable by the process and further relates to electrodes for CDI devices having the material. A method for removing ions from a fluid, like saline water, using the capacitive deionization device includes applying a voltage to the electrodes while supplying the fluid into the capacitive deionization device.

Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.

Abstract: An elevator car (2, 2?), includes a first safety brake (8, 8?), including a first electronic safety actuator (512, 612), the first safety brake (8, 8?) positioned on a first side of the elevator car (2, 2?) at a first height (20, 20?); and a second safety brake (10, 10?), including a second electronic safety actuator (512, 612), the second safety brake (10, 10?) positioned on a second side of the elevator car (2, 2?) at a second height (22, 22?); the first height is different to the second height.

Abstract: Mandibular advancement measurement and positioning device provided with an instrument (1) with an upper slider (2) and a lower slider (3), means to measure and position the relative displacement of both sliders and two trays at one end of the instrument, one upper and one lower (11a, 11b), the trays being attached to each slider respectively, wherein the lower slider is divided into a fixed part (3a) and a pivoting part (3b) joined to the end of the fixed part (3a), being the upper and lower slider joined by means of a recess that allows a relative slide of both and wherein the pivoting part (3b) of the lower slider is provided with a vertical opening control (6). By means of the pivoting part and the opening control it is possible to measure and position the vertical opening.

Abstract: The present invention provides compounds useful in treating or preventing inflammation, acne, bacterial conditions and promoting the appearance of healthy skin and compositions including these compounds.