Patents by Inventor Jose FERNANDEZ-ALCON
Jose FERNANDEZ-ALCON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240093136Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: ApplicationFiled: November 28, 2023Publication date: March 21, 2024Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher Davidd Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Publication number: 20240084235Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.Type: ApplicationFiled: September 19, 2023Publication date: March 14, 2024Inventors: Jose Fernandez-Alcon, Norman Wen, Richard Novak, Donald E. Ingber, Geraldine A. Hamilton, Christopher Hinojosa, Karel Domansky, Daniel Levner, Guy Thompson, II, Kambez Hajipouran Benam, Remi Villenave, Thomas Umundum, Alfred Paris, Georg Bauer
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Patent number: 11920114Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: GrantFiled: February 16, 2021Date of Patent: March 5, 2024Assignee: EMULATE, INC.Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Patent number: 11834641Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: GrantFiled: September 22, 2022Date of Patent: December 5, 2023Assignee: EMULATE, INC.Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Publication number: 20230022203Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: ApplicationFiled: September 22, 2022Publication date: January 26, 2023Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Publication number: 20220372423Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.Type: ApplicationFiled: July 22, 2022Publication date: November 24, 2022Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Daniel LEVNER, Guy THOMPSON, III, Jose FERNANDEZ-ALCON, Christopher David HINOJOSA
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Publication number: 20220364030Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.Type: ApplicationFiled: July 28, 2022Publication date: November 17, 2022Inventors: Christopher David Hinojosa, Josiah Sliz, Daniel Levner, Guy Thompson, Hubert Geisler, Jose Fernandez-Alcon, Donald E. Ingber
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Patent number: 11499131Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.Type: GrantFiled: October 4, 2019Date of Patent: November 15, 2022Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Daniel Levner, Guy Thompson, II, Jose Fernandez-Alcon, Christopher David Hinojosa
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Patent number: 11434458Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.Type: GrantFiled: January 11, 2017Date of Patent: September 6, 2022Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Christopher David Hinojosa, Josiah Sliz, Daniel Levner, Guy Thompson, Hubert Geisler, Jose Fernandez-Alcon, Donald E. Ingber
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Publication number: 20210179992Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: ApplicationFiled: February 16, 2021Publication date: June 17, 2021Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Patent number: 11034926Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.Type: GrantFiled: January 11, 2017Date of Patent: June 15, 2021Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Christopher David Hinojosa, Josiah Sliz, Daniel Levner, Guy Thompson, Hubert Geisler, Jose Fernandez-Alcon, Donald E. Ingber
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Patent number: 10988721Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: GrantFiled: October 5, 2018Date of Patent: April 27, 2021Assignee: EMULATE, Inc.Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Patent number: 10913924Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: GrantFiled: October 5, 2018Date of Patent: February 9, 2021Assignee: Emulate, Inc.Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Publication number: 20200277558Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.Type: ApplicationFiled: October 4, 2019Publication date: September 3, 2020Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Donald E. Ingber, Daniel Levner, Guy Thompson, II, Jose Fernandez-Alcon, Christopher David Hinojosa
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Patent number: 10465158Abstract: Systems and methods interconnect cell culture devices and/or fluidic devices by transferring discrete volumes of fluid between devices. A liquid-handling system collects a volume of fluid from at least one source device and deposits the fluid into at least one destination device. In some embodiments, a liquid-handling robot actuates the movement and operation of a fluid collection device in an automated manner to transfer the fluid between the at least one source device and the at least one destination device. In some cases, the at least one source device and the at least one destination device are cell culture devices. The at least one source device and the at least one destination device may be microfluidic or non-microfluidic devices. In some cases, the cell culture devices may be microfluidic cell culture devices. In further cases, the microfluidic cell culture devices may include organ-chips.Type: GrantFiled: July 11, 2014Date of Patent: November 5, 2019Assignee: President and Fellows of Harvard CollegeInventors: Donald E. Ingber, Daniel Levner, Guy Thompson, II, Jose Fernandez-Alcon, Christopher David Hinojosa
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Patent number: 10407655Abstract: Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.Type: GrantFiled: January 11, 2017Date of Patent: September 10, 2019Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Christopher David Hinojosa, Josiah Sliz, Daniel Levner, Guy Thompson, Hubert Geisler, Jose Fernandez-Alcon, Donald E. Ingber
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Publication number: 20190040349Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: ApplicationFiled: October 5, 2018Publication date: February 7, 2019Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Publication number: 20190040348Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: ApplicationFiled: October 5, 2018Publication date: February 7, 2019Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Patent number: 10184102Abstract: A culture module is contemplated that allows the perfusion and optionally mechanical actuation of one or more microfluidic devices, such as organ-on-a-chip microfluidic devices comprising cells that mimic at least one function of an organ in the body. A method for pressure control is contemplated to allow the control of flow rate (while perfusing cells) despite limitations of common pressure regulators. The method for pressure control allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly, so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Type: GrantFiled: August 26, 2016Date of Patent: January 22, 2019Assignee: Emulate, Inc.Inventors: Daniel Levner, Josiah Daniel Sliz, Christopher David Hinojosa, Joshua Gomes, Jose Fernandez-Alcon
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Publication number: 20170327781Abstract: An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.Type: ApplicationFiled: May 22, 2017Publication date: November 16, 2017Inventors: Jose Fernandez-Alcon, Norman Wen, Richard Novak, Donald E. Ingber, Geraldine A. Hamilton, Christopher Hinojosa, Karel Domansky, Daniel Levner, Guy Thompson, Kambez Hajipouran Benam, Remi Villenave, Thomas Umundum, Alfred Paris, Georg Bauer