Patents by Inventor Joseê Golay

Joseê Golay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Multispecific antigens binding fragments and multispecific antibodies
    Patent number: 11945879
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Grant
    Filed: August 18, 2020
    Date of Patent: April 2, 2024
    Assignees: Jean Kadouche, Centre National de la Recherche Scientifique, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, University of Lausanne
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Multispecific Antibodies
    Publication number: 20210040235
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CHI and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Application
    Filed: August 18, 2020
    Publication date: February 11, 2021
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Multispecific Antibodies
    Publication number: 20200385490
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CHI and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Application
    Filed: August 18, 2020
    Publication date: December 10, 2020
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Multispecific antigen binding fragments and multispecific antibodies derived therefrom comprising mutant CH1 and CL-kappa domains
    Patent number: 10815310
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: October 27, 2020
    Assignees: Centre National de la Recherche Scientifique, Azienda socio sanitaria territoriale Papa Giovanni XXIII, Universite de Lausanne
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • MULTISPECIFIC ANTIGENS BINDING FRAGMENTS AND MULTISPECIFIC ANTIBODIES DERIVED THEREFROM COMPRISING MUTANT CH1 AND CL-KAPPA DOMAINS
    Publication number: 20180022829
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
    Type: Application
    Filed: March 20, 2017
    Publication date: January 25, 2018
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Multispecific antigens binding fragments and multispecific antibodies derived therefrom comprising mutant CH1 and CL-? domains
    Patent number: 9631031
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy/light chain mispairing.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: April 25, 2017
    Assignees: Centre National de la Recherche Scientifique, Azienda Ospedaliera Papa Giovanni XXIII, Universite de Lausanne
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • MULTISPECIFIC MUTATED ANTIBODY FAB FRAGMENTS
    Publication number: 20140242076
    Abstract: The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy/light chain mispairing.
    Type: Application
    Filed: July 6, 2012
    Publication date: August 28, 2014
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE LAUSANNE, AZIENDA OSPEDALIERA PARA GIOVANNI XXIII
    Inventors: Jean Kadouche, Jean-Pierre Mach, Olivier Michielin, Vincent Zoete, Justyna Iwaszkiewicz, Martine Cerutti, Sylvie Choblet, Josee Golay
  • Method for treating Philadelphia-negative myeloproliferative syndromes
    Patent number: 8217079
    Abstract: Method for treating Philadelphia-negative myeloproliferative syndromes in a patient in need of such treatment, by administering to the patient diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride or other pharmaceutically acceptable salts and/or solvates thereof, in combination with N-hydroxyurea.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: July 10, 2012
    Assignee: Italfarmaco SpA
    Inventors: Paolo Mascagni, Carmine D'urzo, Joseê Golay
  • Method for treating Philadelphia-negative myeloproliferative syndromes
    Publication number: 20110237663
    Abstract: A method for treating Philadelphia-negative myeloproliferative syndromes (polycythemia vera, essential thrombocythemia or idiopathic myelofibrosis) which comprises administering diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride or other pharmaceutically acceptable salts and/or solvates thereof, in combination with N-hydroxyurea to a patient in need of such a treatment, is described. The diethyl-[6-(4-hydroxycarbamoyl-phenylcarbamoyloxymethyl)-naphthalen-2-yl-methyl]-ammonium chloride in combination with N-hydroxyurea induces positive therapeutic responses in patients refractory to the N-hydroxyurea monotherapy and/or whose therapeutic response to monotherapy with the same dose of N-hydroxyurea is unsatisfactory.
    Type: Application
    Filed: March 26, 2010
    Publication date: September 29, 2011
    Applicant: ITALFARMACO SPA
    Inventors: Paolo Mascagni, Carmine D'urzo, Joseê Golay
  • Use of antibodies against CD20 for the treatment of the graft versus host disease
    Publication number: 20070014785
    Abstract: It is described the use of antibodies against exogenous surface antigens not present on normal human T lymphocytes for the preparation of compositions for the treatment of the graft versus host disease in patients who have received T lymphocytes transduced with such exogenous surface antigens.
    Type: Application
    Filed: August 3, 2006
    Publication date: January 18, 2007
    Applicant: CONSIGLIO NAZIONALE DELLE RICHERCHE
    Inventors: Josee Golay, Martino Introna, Alessandro Rambaldi, Andrea Biondi