Patents by Inventor Jose Halperin

Jose Halperin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulation of protein synthesis
    Patent number: 8257931
    Abstract: A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: September 4, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Gerhard Wagner, Michael Chorev, Nathan John Moerke, Bertal Huseyin Aktas, José Halperin
  • MASS SPECTROMETRIC METHODS AND PRODUCTS
    Publication number: 20120088251
    Abstract: The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
    Type: Application
    Filed: December 7, 2011
    Publication date: April 12, 2012
    Applicant: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Mass spectrometric methods and products
    Patent number: 8093009
    Abstract: The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: January 10, 2012
    Assignee: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • METHODS, PRODUCTS AND TREATMENTS FOR DIABETES
    Publication number: 20120003754
    Abstract: The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.
    Type: Application
    Filed: August 9, 2011
    Publication date: January 5, 2012
    Applicant: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Methods, products and treatments for diabetes
    Patent number: 8008024
    Abstract: The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: August 30, 2011
    Assignee: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • MASS SPECTROMETRIC METHODS AND PRODUCTS
    Publication number: 20110053177
    Abstract: The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
    Type: Application
    Filed: November 1, 2010
    Publication date: March 3, 2011
    Applicant: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Mass spectrometric methods and products
    Patent number: 7833725
    Abstract: The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
    Type: Grant
    Filed: January 6, 2006
    Date of Patent: November 16, 2010
    Assignee: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Methods, products and treatments for diabetes
    Patent number: 7767791
    Abstract: The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: August 3, 2010
    Assignee: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Regulation of protein synthesis
    Publication number: 20100144805
    Abstract: A composition and method for inhibiting proliferation of a tumor cell compared to a non-tumor cell. Also described are methods of screening for a composition that inhibits cap-dependent translation compared to cap-independent translation of proteins.
    Type: Application
    Filed: January 20, 2006
    Publication date: June 10, 2010
    Inventors: Gerhard Wagner, Michael Chorev, Nathan Moerke, Huseyin Aktas, José Halperin
  • Mass Spectrometric Methods and Products
    Publication number: 20100009378
    Abstract: The invention involves assays, diagnostics, kits, and assay components for mass spectrometry and other methods to determine levels of glycated CD59 in subjects.
    Type: Application
    Filed: January 6, 2006
    Publication date: January 14, 2010
    Applicant: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Methods, Products and Treatments for Diabetes
    Publication number: 20090191574
    Abstract: The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.
    Type: Application
    Filed: October 3, 2008
    Publication date: July 30, 2009
    Applicant: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Use of triaryl methane compounds for inhibiting unwanted cellular proliferation associated with inflammatory disease
    Patent number: 7531573
    Abstract: The present invention provides a class of chemical compounds useful as efficacious drugs in the treatment of sickle cell disease and diseases characterized by unwanted or abnormal cell proliferation, and in particular inflammatory diseases associated with unwanted cellular proliferation. The active compounds are substituted triaryl methane compounds or analogues thereof where one or more of the aryl groups is replaced with a heteroaryl, cycloalkyl or heterocycloalkyl group and/or the tertiary carbon atom is replaced with a different atom such as Si, Ge, N or P. the compounds inhibit mammalian cell proliferation, inhibit the Gardos channel of erythrocytes, reduce sickle erythrocyte dehydration and/or delay the occurrence of erythrocyte sickling or deformation.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: May 12, 2009
    Assignee: Children's Medical Center Corporation
    Inventors: Carlo Brugnara, Jose Halperin, Emile M. Bellot, Jr., Mark Froimowitz, Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Falguni M. Kher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft
  • Anti-glycated CD59 antibodies and uses thereof
    Patent number: 7439330
    Abstract: The invention includes antibodies or antigen-binding fragments thereof which bind specifically to glycated CD59, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of producing and using the antibodies or antigen-binding fragments thereof for diagnosis and treatment of diabetic conditions and diabetic-associated conditions.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: October 21, 2008
    Assignee: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
    Patent number: 7342038
    Abstract: The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: March 11, 2008
    Assignees: President and Fellow of Harvard College, Children's Medical Center Corporation, NuChem Pharmaceuticals Inc.
    Inventors: Carlo Brugnara, Jose Halperin, Rudolf Fluckiger, Emile M. Bellott, Jr., Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft
  • DETECTION OF PHOSPHORYLATED eIF2-alpha AS A DIAGNOSTIC TEST FOR EFFICACY AND SENSITIVITY OF TRANSLATION INITIATION INHIBITORS IN THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES
    Publication number: 20070196848
    Abstract: The present invention relates to methods for determining the effectiveness of one or more agents for treating one or more disorders associated with aberrant cellular proliferation. Screening assays for the discovery of agents that alter eIF2? phosphorylation, inhibit translation initiation and/or inhibit aberrant cellular proliferation are also provided.
    Type: Application
    Filed: February 2, 2007
    Publication date: August 23, 2007
    Applicant: President and Fellows of Harvard College
    Inventors: Jose Halperin, Huseyin Aktas
  • 3-3-DI-SUBSTITUTED-OXINDOLES AS INHIBITORS OF TRANSLATION INITIATION
    Publication number: 20070099976
    Abstract: Compositions and methods for inhibiting translation using 3-(5-tert-Butyl-2-Hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using 3-(5-tert-butyl-2-hydroxy-phenyl)-3-phenyl-1,3-dihydro-indol-2-one and/or its derivatives are described.
    Type: Application
    Filed: August 9, 2006
    Publication date: May 3, 2007
    Applicant: President and Fellows of Harvard College
    Inventors: Jose Halperin, Amarnath Natarajan, Huseyin Aktas, Yun-Hua Fan, Han Chen
  • Methods, products and treatments for diabetes
    Publication number: 20060257936
    Abstract: The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.
    Type: Application
    Filed: April 27, 2006
    Publication date: November 16, 2006
    Applicant: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Methods, products and treatments for diabetes
    Patent number: 7049082
    Abstract: The invention involves assays, diagnostics, kits, and assay components for determining levels of K41-glycated CD59 in subjects. Treatments for subjects based upon levels of K41-glycated CD59 also are provided.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: May 23, 2006
    Assignee: President and Fellows of Harvard College
    Inventor: Jose Halperin
  • Substituted 11-phenyl-dibenzazepine compounds useful for the treatment or prevention of diseases characterized by abnormal cell proliferation
    Patent number: 6992079
    Abstract: The present invention provides substituted 11-phenyl-dibenzazepine compounds which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a therapeutic approach towards the treatment or prevention of diseases characterized by abnormal cell proliferation, such as cancer.
    Type: Grant
    Filed: December 7, 2001
    Date of Patent: January 31, 2006
    Assignees: President Fellows of Harvard College, Children's Medical Center Corporation, NuChem Pharmaceuticals Inc.
    Inventors: Carlo Brugnara, Jose Halperin, Rudolf Fluckiger, Emile M. Bellott, Jr., Richard John Lombardy, John J. Clifford, Ying-Duo Gao, Reem M. Haidar, Eugene W. Kelleher, Adel M. Moussa, Yesh P. Sachdeva, Minghua Sun, Heather N. Taft, Michael H. Zeldin
  • Anti-glycated CD59 antibodies and uses thereof
    Publication number: 20050032128
    Abstract: The invention includes antibodies or antigen-binding fragments thereof which bind specifically to glycated CD59, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of producing and using the antibodies or antigen-binding fragments thereof for diagnosis and treatment of diabetic conditions and diabetic-associated conditions.
    Type: Application
    Filed: June 17, 2004
    Publication date: February 10, 2005
    Applicant: President and Fellows of Harvard College
    Inventor: Jose Halperin