Abstract: A gold(III) complex, a conjugate of the gold(iII) complex, a pharmaceutical composition comprising the gold(III) complex and uses and a process for preparing the gold(III) complex. The complex comprises a group of (S{circumflex over (?)}C)-cyclometallated gold(III) complexes containing a 1,1-dithio ligand, which exhibit antibacterial activity against multiresistant microorganisms or against biofilm activity or biofilm disruption. The gold(III) complex has efficacy against a variety of microorganisms and low toxicity.

Abstract: The present invention relates to the diagnosis and treatment of pelvic floor prolapse. The diagnosis and treatment may involve the use of a multiple sensor-enabled device for vaginal insertion capable of providing real-time data regarding the pa -tient’s physiology, the position and movement of the urethra, and the muscular strength of the patient’s vagina and pelvic floor. The methods and devices of the invention may also be useful to addressing other medical issues, including urinary incontinence, sexual health, and fecal incontinence, as well as facilitate patient home wellness activities.

Abstract: A system and method for optimizing a patient's Kegel exercises is provided. The system includes a user interface device and a vaginal device. The vaginal device includes an intra-vaginal probe having an accelerometer that is configured to generate a signal in response to movement of the probe. The user interface device is connected to the vaginal device and analyzes signals from the accelerometer to provide physiological feedback information to the patient. The vaginal device may be connected to the user interface device via wireless communications such as Bluetooth or by wire. The user interface device may be a smart device or a computer that transmits information to central web-based data server accessible by the patient or authorized healthcare providers or third-party payers.

Abstract: The present disclosure relates to halogenated fatty acid lactylates, in particular to chlorinated fatty acid lactylates. The halogenated fatty acid lactylates now disclosed have antimicrobial and/or antibiofilm activity towards healthcare associated microbial infections.

Abstract: The present invention relates to intravaginal devices, systems including the devices, and methods of using the devices to train an individual in the performance of exercises (e.g., pelvic floor lifts (PFLs) and pelvic floor relaxations (PFRs)) that strengthen the individual's pelvic floor muscles in order to treat or prevent pelvic floor disorders (e.g., pelvic organ prolapse and incontinence) and their accompanying symptoms.

Abstract: A system and method for optimizing a patient's Kegel exercises is provided. The system includes a user interface device and a vaginal device. The vaginal device includes an intra-vaginal probe having an accelerometer that is configured to generate a signal in response to movement of the probe. The user interface device is connected to the vaginal device and analyzes signals from the accelerometer to provide physiological feedback information to the patient. The vaginal device may be connected to the user interface device via wireless communications such as BLUETOOTH® or by wire. The user interface device may be a smart device or a computer that transmits information to central web-based data server accessible by the patient or authorized healthcare providers or third-party payers.

Abstract: Methods and devices to diagnose and treat fecal incontinence in females and males are provided. A multiple sensor-enabled catheter for positioning in a patient's rectum allows for the visualization and manipulation or positioning of an anatomical reference point(s) in the patient's body. A multiple sensor-enabled catheter for rectal insertion in a patient allows for the visualization and implementation of efficient and effective exercises to strengthen pelvic floor muscles.

Abstract: A gold(III) complex, a conjugate of the gold(iII) complex, a pharmaceutical composition comprising the gold(III) complex and uses and a process for preparing the gold(III) complex. The complex comprises a group of (S?C)-cyclometallated gold(III) complexes containing a 1,1-dithio ligand, which exhibit antibacterial activity against multiresistant microorganisms or against biofilm activity or biofilm disruption. The gold(III) complex has efficacy against a variety of microorganisms and low toxicity.

Abstract: Methods and devices to diagnose and treat male urinary incontinence and sexual dysfunction are provided. A multiple sensor-enabled catheter for rectal insertion in a male patient allows for the visualization and manipulation or positioning of the bladder. A multiple sensor-enabled catheter for rectal insertion in a male patient allows for the visualization and implementation of efficient and effective exercises to strengthen pelvic floor muscles.

Abstract: The present invention relates to the diagnosis and treatment of urinary incontinence. Th diagnosis and treatment involves the use of a multiple sensor-enabled catheter capable of providing real-time data regarding the patient's physiology, such as urinary flow and muscular function of the bladder sphincter, as well as the position and movement of the catheter within the patient.

Abstract: Techniques for selectively removing Monte Carlo (MC) noise from a geometric buffer (G-buffer). Embodiments identify the G-buffer for rendering an image of a three-dimensional scene from a viewpoint. Embodiments determine, for each of a plurality of pixels in the image being rendered, respective world position information based on the three-dimensional scene and a position and orientation of the viewpoint. A pre-filtering operation is then performed to selectively remove the MC noise from the G-buffer, based on the determined world position information for the plurality of pixels.

Abstract: Featured are intravaginal devices and methods of using the devices to observe the state of an individual's pelvic floor muscles in order to diagnose, treat, or prevent pelvic floor disorders (e.g., pelvic organ prolapse and incontinence) and their accompanying symptoms and methods of using the devices to treat or prevent vaginal disorders (e.g., skin laxity) in a subject using an energy transmitter (e.g., a radiofrequency transmitter).

Abstract: The present invention relates generally to the field of cancer biology. Some embodiments of the methods and compositions provided herein relate to administration of humanized antibodies or antigen-binding fragments thereof that specifically bind to LRG5 to treat certain cancers.

Abstract: The present invention relates to the diagnosis and treatment of pelvic floor prolapse. The diagnosis and treatment may involve the use of a multiple sensor-enabled device for vaginal insertion capable of providing real-time data regarding the patient's physiology, the position and movement of the urethra, and the muscular strength of the patient's vagina and pelvic floor. The methods and devices of the invention may also be useful to addressing other medical issues, including urinary incontinence, sexual health, and fecal incontinence, as well as facilitate patient home wellness activities.

Abstract: A method and device for the diagnosis and treatment of pelvic floor prolapse is provided. The diagnosis and treatment may involve the use of a multiple sensor-enabled device for vaginal insertion capable of providing real-time data regarding the patient's physiology, the position and movement of the urethra, and the muscular strength of the patient's vagina and pelvic floor. The methods and devices of the invention may also be useful to addressing other medical issues, including urinary incontinence, sexual health, and fecal incontinence, as well as facilitate patient home wellness activities.

Abstract: Techniques for selectively removing Monte Carlo (MC) noise from a geometric buffer (G-buffer). Embodiments identify the G-buffer for rendering an image of a three-dimensional scene from a viewpoint. Embodiments determine, for each of a plurality of pixels in the image being rendered, respective world position information based on the three-dimensional scene and a position and orientation of the viewpoint. A pre-filtering operation is then performed to selectively remove the MC noise from the G-buffer, based on the determined world position information for the plurality of pixels.

Abstract: Techniques for selectively removing Monte Carlo (MC) noise from a geometric buffer (G-buffer). Embodiments identify the G-buffer for rendering an image of a three-dimensional scene from a viewpoint. Embodiments determine, for each of a plurality of pixels in the image being rendered, respective world position information based on the three-dimensional scene and a position and orientation of the viewpoint. A pre-filtering operation is then performed to selectively remove the MC noise from the G-buffer, based on the determined world position information for the plurality of pixels.

Abstract: The present invention relates to intravaginal devices, systems including the devices, and methods of using the devices to train an individual in the performance of exercises (e.g., pelvic floor lifts (PFLs) and pelvic floor relaxations (PFRs)) that strengthen the individual's pelvic floor muscles in order to treat or prevent pelvic floor disorders (e.g., pelvic organ prolapse and incontinence) and their accompanying symptoms.

Abstract: The present invention relates generally to the field of cancer biology.

Abstract: The present invention relates to cancer markers that are predictive for cancer patent response to treatment with an m TOR inhibitor and a vascular disrupting agent. The present invention further relates to methods of treating a cancer patient subpopulation with a combination of an m TOR inhibitor and a vascular disrupting agent.