Abstract: A therapeutic instrument, and method, for radiation treatment of patients with carcinoma of the cervix and uterus. An elongated uterovaginal tandem having a curved proximal end is inserted in the uterine cavity, and an intravaginal applicator having a bore receiving the tandem is slid over the tandem into the vagina, and the tandem and applicator are fixed so that no relative motion therebetween is possible. The applicator obviates the need for packing of the vagina, having a quadrate cross-section, with rounded corners that substantially fills the vagina if the appropriate size of applicator is selected. Sutures are used to connect the distal end of the applicator adjacent the vaginal introitus. The applicator is then loaded with a pair of containers of irradiative material, the containers inserted utilizing handles through passageways in the applicator to cavities in the applicator on either side of the tandem and adjacent the slanted proximal end of the applicator.