Patents by Inventor Jose-Luis Diaz

Jose-Luis Diaz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240239781
    Abstract: The present invention relates to new 1H-pyrazole derivatives of formula (I) as sigma ligands having a great affinity for sigma receptors, especially the sigma-1 receptor (?1) and/or sigma-2 receptor (?2), as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: April 19, 2022
    Publication date: July 18, 2024
    Inventors: Ana Virginia LLORENTE-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Mónica GARCÍA-LÓPEZ, Ute CHRISTMANN, Jose Luís DÍAZ-FERNÁNDEZ
  • Publication number: 20240217959
    Abstract: The present invention relates to new compounds of formula (I) as sigma ligands having a great affinity for sigma receptors, sigma-1 receptor (?1) and/or sigma-2 receptor (?2). The present invention also refers to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: April 6, 2022
    Publication date: July 4, 2024
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: José Luis DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Ute CHRISTMANN
  • Publication number: 20240182489
    Abstract: The present invention relates to new 5,6,7,8-tetrahydropyrido[4?,3?:4,5]thieno[2,3d] pyrimidin-4(3H)-one derivatives as sigma ligands having a great affinity for sigma receptors, especially sigma-1 (?1), as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: March 17, 2022
    Publication date: June 6, 2024
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: Ute CHRISTMANN, Jose Luís DÍAZ-FERNÁNDEZ
  • Publication number: 20240174671
    Abstract: The present invention relates to new 2,3-dihydro-1H-pyrrolo[3,2-b]pyridine derivatives of formula (I): as sigma ligands having a great affinity for sigma receptors, especially sigma-1 (?1) and/or sigma-2 (?2) receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: March 8, 2022
    Publication date: May 30, 2024
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: Marina VIRGILI-BERNADÓ, Mónica ALONSO-XALMA, Carmen ALMANSA-ROSALES, Jose Luís DÍAZ-FERNÁNDEZ, Adriana LORENTE-CRIVILLÉ
  • Publication number: 20240059690
    Abstract: The present invention relates to pyrazolopyrimidine derivatives having dual pharmacological activity towards both the ?2? subunit of the voltage-gated calcium channel and the sigma-1 (?1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 20, 2021
    Publication date: February 22, 2024
    Inventors: Ariadna FERNANDEZ-DONIS, José-Luis DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Mónica GARCIA-LOPEZ, Joan-Carles FERNANDEZ-COLLADO, Jordi GONZALEZ-GARCIA, Maria GARRIDO-MARTINEZ
  • Publication number: 20230346532
    Abstract: Mandibular advancement measurement and positioning device provided with an instrument (1) with an upper slider (2) and a lower slider (3), means to measure and position the relative displacement of both sliders and two trays at one end of the instrument, one upper and one lower (11a, 11b), the trays being attached to each slider respectively, wherein the lower slider is divided into a fixed part (3a) and a pivoting part (3b) joined to the end of the fixed part (3a), being the upper and lower slider joined by means of a recess that allows a relative slide of both and wherein the pivoting part (3b) of the lower slider is provided with a vertical opening control (6). By means of the pivoting part and the opening control it is possible to measure and position the vertical opening.
    Type: Application
    Filed: August 11, 2021
    Publication date: November 2, 2023
    Inventors: Daniel FERNÁNDEZ FAJARDO, José Luis DIAZ GONZÁLEZ, Juan José FERNÁNDEZ VIDAL, Daniel SÁNCHEZ ALBERTOS
  • Publication number: 20220380345
    Abstract: The present invention relates to homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having dual pharmacological activity towards both the ?2? subunit of the voltage-gated calcium channel and the sigma-1 (?1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 5, 2020
    Publication date: December 1, 2022
    Inventors: Carmen ALMANSA-ROSALES, Ariadna FERNANDEZ-DONIS, José-Luís DÍAZ-FERNÁNDEZ, Monica GARCIA-LOPEZ, Sergi RODRIGUEZ-ESCRICH, Ute CHRISTMANN
  • Publication number: 20220002314
    Abstract: The present invention relates to piperazinyl and piperidinyl quinazolin-4(3H)-one derivatives having pharmacological activity towards the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 31, 2019
    Publication date: January 6, 2022
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: Ariadna FERNÁNDEZ-DONIS, Jose Luís DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Adriana LORENTE-CRIVILLÉ
  • Publication number: 20200190081
    Abstract: The present invention relates to meta substituted phenylpyrazolo- and phenylpyrrolo-pyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the NET receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 30, 2017
    Publication date: June 18, 2020
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carmen ALMANSA-ROSALES, José-Luis DÍAZ-FERNÁNDEZ
  • Patent number: 10577360
    Abstract: The present invention relates to arylamide derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: March 3, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Pilar Goya, Antoni Torrens-Jover, Carmen Almansa-Rosales, Jose-Luis Diaz-Fernández, Ana-Maria Caamaño-Moure
  • Publication number: 20200062767
    Abstract: The present invention relates to substituted pyrrolidinyl and piperidinyl pyrazolopyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2??1 subunit, of the voltage-gated calcium channel and the Noradrenaline transporter (NET), to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 29, 2018
    Publication date: February 27, 2020
    Inventors: Carmen ALMANSA-ROSALES, José-Luís DÍAZ-FERNÁNDEZ, Ariadna FERNANDEZ-DONIS, Susana YENES-MINGUEZ
  • Publication number: 20200002283
    Abstract: The present invention relates to pyrazole derivatives having pharmacological activity towards the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: June 26, 2017
    Publication date: January 2, 2020
    Inventors: Carmen ALMANSA-ROSALES, Susana YENES-MÍNGUEZ, José-Luis DÍAZ-FERNÁNDEZ, Antonio David RODRIGUEZ-GARRIDO
  • Patent number: 9963453
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 8, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Ramón Merce-Vidal, José-Luis Díaz-Fernández, Carmen Almansa-Rosales
  • Patent number: 9879015
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: January 30, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Ramón Merce-Vidal, José-Luis Díaz-Fernández
  • Patent number: 9676784
    Abstract: The present invention relates to new fused imidazolyl derivatives having a high affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: June 13, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luis Díaz-Fernández, Carmen Almansa-Rosales, Piotr Nieczypor
  • Patent number: 9617281
    Abstract: The present invention relates to new imidazo[2,1-b]thiazole derivatives having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: April 11, 2017
    Assignee: LABORATORIES DEL DR. ESTEVE S.A.
    Inventors: María de las Ermitas Alcalde-Pais, José Luís Diaz Fernández, María de les Neus Mesquida-Estevez, Laura Paloma-Romeu
  • Patent number: 9611229
    Abstract: The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: April 4, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Antoni Torrens-Jover, Ute Christmann, Josè-Luis Diaz-Fernández, Carmen Almansa-Rosales
  • Patent number: 9567338
    Abstract: Pyrazolo[3,4-d]pyrimidine compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as a process for preparing these compounds, compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: February 14, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Maria Rosa Cuberes-Altisent, Jordi Corbera-Arjona, Jose Luis Diaz-Fernandez, Carmen Almansa-Rosales
  • Patent number: 9512142
    Abstract: The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: December 6, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luís Díaz-Fernández, Carmen Almansa-Rosales, Félix Cuevas-Cordobés
  • Patent number: 9493434
    Abstract: The present invention relates to new indene derivatives of formula (I) having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: November 15, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Maria de las Ermitas Alcalde-Pais, Carmen Almansa-Rosales, José´Luis Diaz Fernández, María de les Neus Mesquida-Estevez, Laura Paloma-Romeu