Patents by Inventor Jose Luis Diaz-Fernandez

Jose Luis Diaz-Fernandez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20240059690
    Abstract: The present invention relates to pyrazolopyrimidine derivatives having dual pharmacological activity towards both the ?2? subunit of the voltage-gated calcium channel and the sigma-1 (?1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 20, 2021
    Publication date: February 22, 2024
    Inventors: Ariadna FERNANDEZ-DONIS, José-Luis DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Mónica GARCIA-LOPEZ, Joan-Carles FERNANDEZ-COLLADO, Jordi GONZALEZ-GARCIA, Maria GARRIDO-MARTINEZ
  • HOMOPIPERAZINYL AND HOMOPIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20220380345
    Abstract: The present invention relates to homopiperazinyl and homopiperidinyl quinazolin-4(3H)-one derivatives having dual pharmacological activity towards both the ?2? subunit of the voltage-gated calcium channel and the sigma-1 (?1) receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 5, 2020
    Publication date: December 1, 2022
    Inventors: Carmen ALMANSA-ROSALES, Ariadna FERNANDEZ-DONIS, José-Luís DÍAZ-FERNÁNDEZ, Monica GARCIA-LOPEZ, Sergi RODRIGUEZ-ESCRICH, Ute CHRISTMANN
  • PIPERAZINYL AND PIPERIDINYL QUINAZOLIN-4(3H)-ONE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
    Publication number: 20220002314
    Abstract: The present invention relates to piperazinyl and piperidinyl quinazolin-4(3H)-one derivatives having pharmacological activity towards the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: October 31, 2019
    Publication date: January 6, 2022
    Applicant: ACONDICIONAMIENTO TARRASENSE
    Inventors: Ariadna FERNÁNDEZ-DONIS, Jose Luís DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Adriana LORENTE-CRIVILLÉ
  • META SUBSTITUTED PHENYLPYRAZOLO- AND PHENYLPYRROLO- PYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200190081
    Abstract: The present invention relates to meta substituted phenylpyrazolo- and phenylpyrrolo-pyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the NET receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: November 30, 2017
    Publication date: June 18, 2020
    Inventors: Marina VIRGILI-BERNADO, Monica ALONSO-XALMA, Carmen ALMANSA-ROSALES, José-Luis DÍAZ-FERNÁNDEZ
  • Arylamide derivatives having multimodal activity against pain
    Patent number: 10577360
    Abstract: The present invention relates to arylamide derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Grant
    Filed: April 12, 2017
    Date of Patent: March 3, 2020
    Assignee: ESTEVE PHARMACEUTICALS, S.A.
    Inventors: Pilar Goya, Antoni Torrens-Jover, Carmen Almansa-Rosales, Jose-Luis Diaz-Fernández, Ana-Maria Caamaño-Moure
  • SUBSTITUTED PYRROLIDINYL AND PIPERIDINYL PYRAZOLOPYRIDAZINE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
    Publication number: 20200062767
    Abstract: The present invention relates to substituted pyrrolidinyl and piperidinyl pyrazolopyridazine derivatives having dual pharmacological activity towards both the ?2? subunit, in particular the ?2??1 subunit, of the voltage-gated calcium channel and the Noradrenaline transporter (NET), to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: May 29, 2018
    Publication date: February 27, 2020
    Inventors: Carmen ALMANSA-ROSALES, José-Luís DÍAZ-FERNÁNDEZ, Ariadna FERNANDEZ-DONIS, Susana YENES-MINGUEZ
  • PYRAZOLE DERIVATIVES HAVING ACTIVITY AGAINST PAIN
    Publication number: 20200002283
    Abstract: The present invention relates to pyrazole derivatives having pharmacological activity towards the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel, in particular having dual pharmacological activity towards both the ?2? subunit, in particular the ?2?-1 subunit, of the voltage-gated calcium channel and the ?-opioid receptor. The present invention also relates to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain.
    Type: Application
    Filed: June 26, 2017
    Publication date: January 2, 2020
    Inventors: Carmen ALMANSA-ROSALES, Susana YENES-MÍNGUEZ, José-Luis DÍAZ-FERNÁNDEZ, Antonio David RODRIGUEZ-GARRIDO
  • Substituted pyrazino[1,2-a]indoles as sigma receptor activity modulators
    Patent number: 9963453
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: May 8, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Ramón Merce-Vidal, José-Luis Díaz-Fernández, Carmen Almansa-Rosales
  • Pyrazino[1,2-a]indole compounds, their preparation and use in medicaments
    Patent number: 9879015
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: January 30, 2018
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Ramón Merce-Vidal, José-Luis Díaz-Fernández
  • Fused imidazolyl derivatives, their preparation and use as medicaments
    Patent number: 9676784
    Abstract: The present invention relates to new fused imidazolyl derivatives having a high affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: June 13, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luis Díaz-Fernández, Carmen Almansa-Rosales, Piotr Nieczypor
  • Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments
    Patent number: 9617281
    Abstract: The present invention relates to new imidazo[2,1-b]thiazole derivatives having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: July 4, 2013
    Date of Patent: April 11, 2017
    Assignee: LABORATORIES DEL DR. ESTEVE S.A.
    Inventors: María de las Ermitas Alcalde-Pais, José Luís Diaz Fernández, María de les Neus Mesquida-Estevez, Laura Paloma-Romeu
  • 1,2,3-triazole-4-amine derivatives for the treatment of sigma receptor related diseases and disorders
    Patent number: 9611229
    Abstract: The present invention relates to new 1,2,3-triazole-amine derivatives, having affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments for the treatment of sigma receptor related diseases and disorders.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: April 4, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Antoni Torrens-Jover, Ute Christmann, Josè-Luis Diaz-Fernández, Carmen Almansa-Rosales
  • Pyrazolo[3,4-]pyrimidine compounds, their preparation and use as sigma ligands
    Patent number: 9567338
    Abstract: Pyrazolo[3,4-d]pyrimidine compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as a process for preparing these compounds, compositions comprising them and their use as medicaments.
    Type: Grant
    Filed: July 13, 2012
    Date of Patent: February 14, 2017
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: Maria Rosa Cuberes-Altisent, Jordi Corbera-Arjona, Jose Luis Diaz-Fernandez, Carmen Almansa-Rosales
  • Tricyclic triazolic compounds
    Patent number: 9512142
    Abstract: The present invention relates to new tricyclic triazolic compounds having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: December 6, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luís Díaz-Fernández, Carmen Almansa-Rosales, Félix Cuevas-Cordobés
  • Substituted pyrazolo[1,5-A]pyridines, their preparation and use as medicaments
    Patent number: 9487513
    Abstract: The present invention relates to new substituted pyrazolo[1,5-a]pyridine having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: February 21, 2013
    Date of Patent: November 8, 2016
    Assignee: LABORATORIOS DE DR. ESTEVE S.A.
    Inventors: José Luis Diaz Fernández, Ma Rosa Cuberes Altisent
  • FUSED IMIDAZOLYL DERIVATIVES, THEIR PREPARATION AND USE AS MEDICAMENTS
    Publication number: 20160311828
    Abstract: The present invention relates to new fused imidazolyl derivatives having a high affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 27, 2016
    Inventors: José-Luís DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES, Piotr NIECZYPOR
  • Substituted pyrano and furanoquinolines, their preparation and use as medicaments
    Patent number: 9408842
    Abstract: The present invention relates to new substituted pyrano and furanoquinolines having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: August 20, 2015
    Date of Patent: August 9, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José-Luis Diaz-Fernández, Ute Christmann
  • PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS
    Publication number: 20160075709
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Application
    Filed: April 22, 2014
    Publication date: March 17, 2016
    Inventors: Ramón MERCE-VIDAL, José-Luis DÍAZ-FERNÁNDEZ, Carmen ALMANSA-ROSALES
  • Substituted pyrazolo[3,4-]pyrimidine compounds, their preparation and use as sigma receptors ligands
    Patent number: 9278974
    Abstract: The present invention relates to new substituted pyrazolo[3,4-d]pyrimidine compounds, having a great affinity for sigma receptors, especially sigma-1 receptor, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
    Type: Grant
    Filed: November 14, 2013
    Date of Patent: March 8, 2016
    Assignee: LABORATORIOS DEL DR. ESTEVE S.A.
    Inventors: José Luis Díaz Fernández, Carme Almansa, Jordi Corbera Arjona
  • PYRAZINO[1,2-a]INDOLE COMPOUNDS, THEIR PREPARATION AND USE IN MEDICAMENTS
    Publication number: 20160060268
    Abstract: The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in pain therapy.
    Type: Application
    Filed: April 22, 2014
    Publication date: March 3, 2016
    Inventors: Ramón MERCE-VIDAL, José-Luís DÍAZ-FERNÁNDEZ