Patents by Inventor Jose M. C. Ribeiro

Jose M. C. Ribeiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • polypeptides and methods of use
    Patent number: 10314900
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: June 11, 2019
    Assignees: The United States of America, as represted by the Secretary, Department of Health and Human Services, Fundaçao Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • polypeptides and methods of use
    Patent number: 9884100
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishishmaniasis are disclosed.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: February 6, 2018
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundacão Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • Aegyptin and uses thereof
    Patent number: 9441022
    Abstract: The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: September 13, 2016
    Assignees: The United States of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Eric Calvo, Osvaldo Marinotti, Jose M. C. Ribeiro, Ivo M. Francischetti
  • polypeptides and methods of use
    Patent number: 9382302
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: July 5, 2016
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundação Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • polypeptides and methods of use
    Patent number: 9120867
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: September 1, 2015
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Netto, Claudia I. Brodskyn, Regis Gomes
  • Aegyptin and uses thereof
    Patent number: 8980859
    Abstract: The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
    Type: Grant
    Filed: January 22, 2013
    Date of Patent: March 17, 2015
    Assignees: The United States of America, as represented by the Secretary, Department of Health & Human Services, The Regents of the University of California
    Inventors: Eric Calvo, Osvaldo Marinotti, Jose M. C. Ribeiro, Ivo M. Francischetti
  • Lutzomyia longipalpis polypeptides and methods of use
    Patent number: 8628780
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: January 14, 2014
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundação Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Netto, Claudia Brodskyn, Regis Gomes
  • Aegyptin and uses thereof
    Patent number: 8383589
    Abstract: The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed.
    Type: Grant
    Filed: July 7, 2008
    Date of Patent: February 26, 2013
    Assignees: The United States of America, as Represented by the Secretary, Department of Health and Human Services, Regents of the University of California
    Inventors: Eric Calvo, Osvaldo Marinotti, Jose M. C. Ribeiro, Ivo M. Francischetti
  • Anti-arthropod vector vaccines, methods of selecting and uses thereof
    Patent number: 8343499
    Abstract: The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent Leishmaniasis.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: January 1, 2013
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jesus G. Valenzuela, Yasmine Belkaid, Shaden Kamhawi, David Sacks, Jose M. C. Ribeiro
  • Anti-arthropod vector vaccines, methods of selecting and uses thereof
    Patent number: 7964576
    Abstract: The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent Leishmaniasis.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: June 21, 2011
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jesus G. Valenzuela, Yasmine Belkaid, Shaden Kamhawi, David Sacks, Jose M. C. Ribeiro
  • polypeptides and methods of use
    Patent number: 7485306
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: February 3, 2009
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jesus G Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Netto, Claudia Brodskyn, Regis Gomes
  • Anti-arthropod vector vaccines method of selecting and uses thereof
    Patent number: 7388089
    Abstract: The present invention provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present invention also provides compositions for vaccines to prevent Leishmaniasis.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: June 17, 2008
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Jesus G. Valenzuela, Yasmine Belkaid, Shaden Kamhawi, David Sacks, Jose M. C. Ribeiro
  • Ixodes salivary anticomplement protein
    Patent number: 7153947
    Abstract: Isac, a novel protein with anticomplement activity is disclosed. Isac can be isolated from the salivary glands of ticks or made by recombinant methods using various DNA expression techniques.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: December 26, 2006
    Assignees: The United States of America as represented by the Department of Health and Human Services, University of Rhode Island
    Inventors: José M. C. Ribeiro, Jesus G. Valenzuela, Rosane Charlab, Thomas N. Mather
  • Ixodes scapularis tissue factor pathway inhibitor
    Patent number: 7078508
    Abstract: Ixolaris, a novel protein with anticoagulant activity is described. Ixolaris can be isolated from the salivary glands of ticks or made by recombinant methods using various DNA expression techniques.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: July 18, 2006
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Ivo M. B. Francischetti, Jesus G. Valenzuela, José M. C. Ribeiro
  • Methods of use of recombinant vasoactive protein from salivary gland of the black fly
    Patent number: 6749855
    Abstract: The invention is drawn to vasodilative proteins from the salivary glands of the species, Simulium. The protein additionally has immunomodulating activities. Methods for recombinant production of the protein as well as biomedical uses are provided.
    Type: Grant
    Filed: August 14, 2002
    Date of Patent: June 15, 2004
    Assignees: Auburn University, University of Arizona
    Inventors: Mary S. Cupp, Jose M. C. Ribeiro, Eddie W. Cupp
  • Ixodes scapularis tissue factor pathway inhibitor
    Publication number: 20040018516
    Abstract: Ixolaris, a novel protein with anticoagulant activity is described. Ixolaris can be isolated from the salivary glands of ticks or made by recombinant methods using various DNA expression techniques.
    Type: Application
    Filed: April 4, 2003
    Publication date: January 29, 2004
    Inventors: Ivo M.B. Francischetti, Jesus G. Valenzuela, Jose M. C. Ribeiro
  • Recombinant vasoactive protein from salivary gland of the black fly
    Patent number: 6500420
    Abstract: The invention is drawn to vasodilative proteins from the salivary glands of the species, Simulium. The protein additionally has immunomodulating activities. Methods for recombinant production of the protein as well as biomedical uses are provided.
    Type: Grant
    Filed: October 31, 2000
    Date of Patent: December 31, 2002
    Assignees: Auburn University, The University of Arizona
    Inventors: Mary S. Cupp, Jose M. C. Ribeiro, Eddie W. Cupp
  • Recombinant vasoactive protein from salivary gland of the black fly
    Patent number: 6162785
    Abstract: The invention is drawn to vasodilative proteins from the salivary glands of the species, Simulium. The protein additionally has immunomodulating activities. Methods for recombinant production of the protein as well as biomedical uses are provided.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: December 19, 2000
    Assignees: Auburn University, University of Arizona
    Inventors: Mary S. Cupp, Jose M. C. Ribeiro, Eddie W. Cupp, Steven F. Swaim
  • Vasodilatory and immune suppressant peptides
    Patent number: 5763271
    Abstract: Disclosed are proteins derived from the sand fly Lutzomyia longipalpis capable of inducing vasodilation in mammals and data characterizing the proteins and nucleic acids encoding the proteins. Also disclosed is a method for temporarily inactivating the immune system in a mammal comprising administering to the mammal the Lutzomyia protein, CGRP, calcitonin, or active immune suppressing analogs thereof.
    Type: Grant
    Filed: April 26, 1994
    Date of Patent: June 9, 1998
    Assignee: The President and Fellows of Harvard College
    Inventors: Jose M. C. Ribeiro, Richard G. Titus, Charles B. Shoemaker, Heinz G. Remold, Ethan A. Lerner
  • Vasodilatory peptides from the salivary gland of the sand fly Lutzomyia longipalpis
    Patent number: 5397772
    Abstract: Disclosed are proteins derived from the sand fly Lutzomyia longipalpis capable of inducing vasodilation in mammals, and data characterizing the proteins and nucleic acid encoding the proteins. Also disclosed is a method for temporarily inactivating the immune system in a mammal comprising administering to the mammal the Lutzomyia protein, CGRP, calcitonin, or active immune suppressing analogs thereof.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: March 14, 1995
    Assignee: The President and Fellows of Harvard College
    Inventors: Jose M. C. Ribeiro, Ethan A. Lerner, Heinz G. Remold, Richard G. Titus