Patents by Inventor Jose M. Cano
Jose M. Cano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10466165Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.Type: GrantFiled: September 25, 2017Date of Patent: November 5, 2019Assignee: Beckman Coulter, Inc.Inventors: Marshall Donnie Graham, William Gerry Graham, James P. Clarkin, Mark A. Wells, Jose M. Cano, Carlos Alberto Arboleda, Armando J. Sanchez
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Publication number: 20180188154Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.Type: ApplicationFiled: September 25, 2017Publication date: July 5, 2018Applicant: Beckman Coulter, Inc.Inventors: Marshall Donnie Graham, William Gerry Graham, James P. Clarkin, Mark A. Wells, Jose M. Cano, Carlos Alberto Arboleda, Armando J. Sanchez
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Patent number: 9772274Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.Type: GrantFiled: March 14, 2014Date of Patent: September 26, 2017Assignee: Beckman Coulter, Inc.Inventors: Marshall Donnie Graham, William Gerry Graham, James P. Clarkin, Mark A. Wells, Jose M. Cano, Carlos Alberto Arboleda, Armando J. Sanchez
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Publication number: 20160011098Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells) in liquid suspensions. Preferably manufactured by assembling, aligning, and optically joining at least two elements made from transparent material, the improved flow cell has a seamless internal flow channel of preferably non-circular cross-section in a cylindrical first element through which prepared samples can be metered and an independent second element having an external envelope suited to acquisition of optical parameters from formed bodies in such suspensions, the second element being conforming and alignable to the first element so that non-axisymmetric refractive effects on optical characterizing parameters of formed bodies passing through the flow channel in the first element may be minimized before the two elements are optically joined and fixed in working spatial relationship.Type: ApplicationFiled: March 14, 2014Publication date: January 14, 2016Inventors: Marshall Donnie GRAHAM, William Gerry GRAHAM, James P. CLARKIN, Mark A. WELLS, Jose M. CANO, Carlos Alberto ARBOLEDA, Armando J. SANCHEZ
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Patent number: 8916384Abstract: A pipelining assembly for use in a blood analyzing instrument, methods for performing parallel pipelining functions, and methods for processing a plurality of prepared blood samples through a blood analyzing instrument. The pipelining assembly presented generally includes a first sample preparation chamber, a first queuing chamber in fluid communication with the first sample preparation chamber, and a first control valve between the first sample preparation chamber and the first queuing chamber. The pipelining assembly further includes a second sample preparation chamber, a second queuing chamber in fluid communication with the second sample preparation chamber, and a second control valve between the second sample preparation chamber and the second queuing chamber. An analysis chamber is provided to receive first and second prepared blood samples from the in first and second queuing chambers.Type: GrantFiled: April 10, 2012Date of Patent: December 23, 2014Assignee: Beckman Coulter, Inc.Inventors: Carlos A. Perez, Jose M. Cano, Joe C. Schorsch, Viviana A. Vargas
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Patent number: 8339585Abstract: Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss.Type: GrantFiled: December 6, 2011Date of Patent: December 25, 2012Assignee: Beckman Coulter, Inc.Inventors: Mark A. Wells, Carlos A. Perez, Jose M. Cano
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Publication number: 20120208228Abstract: A pipelining assembly for use in a blood analyzing instrument, methods for performing parallel pipelining functions, and methods for processing a plurality of prepared blood samples through a blood analyzing instrument. The pipelining assembly presented generally includes a first sample preparation chamber, a first queuing chamber in fluid communication with the first sample preparation chamber, and a first control valve between the first sample preparation chamber and the first queuing chamber. The pipelining assembly further includes a second sample preparation chamber, a second queuing chamber in fluid communication with the second sample preparation chamber, and a second control valve between the second sample preparation chamber and the second queuing chamber. An analysis chamber is provided to receive first and second prepared blood samples from the in first and second queuing chambers.Type: ApplicationFiled: April 10, 2012Publication date: August 16, 2012Inventors: Carlos A. Perez, Jose M. Cano, Joe C. Schorsch, Viviana A. Vargas
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Patent number: 8189187Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells). Manufactured from a monolithic transparent material, the improved flow cell has an internal flow channel of polygonal transverse cross-section through which prepared samples can be metered and an external envelope suited to acquisition of optical parameters from formed bodies in such samples. Preferably, such flow cell is formed by a glass-drawing process in which a relatively large glass preform having a rectilinear internal channel of a desired polygonal cross-sectional shape is heated and drawn to achieve a desired cross-sectional area of reduced size. Also disclosed are preferred methods for differentiating formed bodies using the flow cell of the invention.Type: GrantFiled: November 13, 2009Date of Patent: May 29, 2012Assignee: Beckman Coulter, Inc.Inventors: Marshall Donnie Graham, William Gerry Graham, James P. Clarkin, Mark A. Wells, Jose M. Cano, Carlos Alberto Arboleda, Armando Jose Sanchez
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Publication number: 20120075630Abstract: Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss.Type: ApplicationFiled: December 6, 2011Publication date: March 29, 2012Applicant: Beckman Coulter, Inc.Inventors: Mark A. Wells, Carlos A. Perez, Jose M. Cano
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Patent number: 8094299Abstract: Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss.Type: GrantFiled: July 24, 2008Date of Patent: January 10, 2012Assignee: Beckman Coulter, Inc.Inventors: Mark A. Wells, Carlos A. Perez, Jose M. Cano
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Publication number: 20100329927Abstract: A pipelining assembly for use in a blood analyzing instrument, methods for performing parallel pipelining functions, and methods for processing a plurality of prepared blood samples through a blood analyzing instrument. The pipelining assembly presented generally includes a first sample preparation chamber, a first queuing chamber in fluid communication with the first sample preparation chamber, and a first control valve between the first sample preparation chamber and the first queuing chamber. The pipelining assembly further includes a second sample preparation chamber, a second queuing chamber in fluid communication with the second sample preparation chamber, and a second control valve between the second sample preparation chamber and the second queuing chamber. An analysis chamber is provided to receive first and second prepared blood samples from the in first and second queuing chambers.Type: ApplicationFiled: June 26, 2009Publication date: December 30, 2010Inventors: Carlos A. Perez, Jose M. Cano, Joe C. Schorsch, Viviana A. Vargas
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Publication number: 20100290041Abstract: An improved optical flow cell adapted for use in a flow cytometer for differentiating formed bodies (e.g., blood cells). Manufactured from a monolithic transparent material, the improved flow cell has an internal flow channel of polygonal transverse cross-section through which prepared samples can be metered and an external envelope suited to acquisition of optical parameters from formed bodies in such samples. Preferably, such flow cell is formed by a glass-drawing process in which a relatively large glass preform having a rectilinear internal channel of a desired polygonal cross-sectional shape is heated and drawn to achieve a desired cross-sectional area of reduced size. Also disclosed are preferred methods for differentiating formed bodies using the flow cell of the invention.Type: ApplicationFiled: November 13, 2009Publication date: November 18, 2010Applicant: Beckman Coulter, Inc.Inventors: Marshall Donnie GRAHAM, William Gerry GRAHAM, James P. CLARKIN, Mark A. WELLS, Jose M. CANO, Carlos Alberto ARBOLEDA, Armando Jose SANCHEZ
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Patent number: 7661326Abstract: Apparatus for aspirating and dispensing liquid samples in an analytical instrument, e.g., a hematology instrument, includes a liquid-sampling valve that, while operating to segment and position for dispensing one or more precise volumes of a liquid sample that has been aspirated into the valve by a pump, simultaneously enables the apparatus to be operated in an aspirate/dispense (suck-and-spit) mode in which a liquid sample can be selectively driven through the valve in opposite directions by a pump, e.g., a syringe pump.Type: GrantFiled: October 26, 2006Date of Patent: February 16, 2010Assignee: Beckman Coulter, Inc.Inventors: William W. Li, William J. Casey, Craig R. Veiner, Carlos R. Gonzalez, Jose M. Cano, Roberto Del Valle, Santiago Galvez
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Publication number: 20100020308Abstract: Transducer modules for use in a blood analysis instrument and methods for analyzing a blood sample. The transducer modules presented generally include a light source, a focus-alignment system, a flow cell, and a light scatter detection system. Electrodes within the flow cell allow for the measurement of the DC impedance and RF conductivity of cells passing through a cell-interrogation zone in the flow cell. Light scatter from the cells passing through the cell-interrogation zone is measured by the light scatter detection system. The light scatter detection system measures the light scatter parameters of upper median light scatter, lower median angle light scatter, low angle light scatter, and axial light loss.Type: ApplicationFiled: July 24, 2008Publication date: January 28, 2010Inventors: Mark A. Wells, Carlos A. Perez, Jose M. Cano
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Publication number: 20080098828Abstract: Apparatus for aspirating and dispensing liquid samples in an analytical instrument, e.g., a hematology instrument, includes a liquid-sampling valve that, while operating to segment and position for dispensing one or more precise volumes of a liquid sample that has been aspirated into the valve by a pump, simultaneously enables the apparatus to be operated in an aspirate/dispense (suck-and-spit) mode in which a liquid sample can be selectively driven through the valve in opposite directions by a pump, e.g., a syringe pump.Type: ApplicationFiled: October 26, 2006Publication date: May 1, 2008Applicant: BECKMAN COULTER, INC.Inventors: William W. Li, William J. Casey, Craig R. Veiner, Carlos R. Gonzalez, Jose M. Cano, Roberto Del Valle, Santiago Galvez
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Patent number: 6228652Abstract: A blood analyzing instrument includes a single transducer for simultaneously measuring the DC volume, RF conductivity, light scattering and fluorescence characteristics of blood cells passing through a cell-interrogation zone. Preferably, the transducer includes an electro-optical flow cell which defines a cell-interrogation zone having a square transverse cross-section measuring approximately 50×50 microns, and having a length, measured in the direction of cell flow, of approximately 65 microns.Type: GrantFiled: February 16, 1999Date of Patent: May 8, 2001Assignee: Coulter International Corp.Inventors: Carlos M. Rodriguez, Jose M. Cano, Barbara Carrillo, Kristie M. Gordon, Allan F. Horton, Ronald D. Paul, Mark A. Wells, James L. Wyatt