Patents by Inventor Jose Manuel Galindro

Jose Manuel Galindro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Manufacture of a triiodinated contrast agent
    Patent number: 8835672
    Abstract: A new compound, (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid, of formula II (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid. Said new compound is of use for the production of triiodinated contrast agent, especially lopamidol, with low content of acetyl and hydroxyacetyl analogs. The new compound may be formed from 5-amino-2,4,6-triiodoisophtalic acid by acylating with (S)-1-chloro-1-oxopropan-2-yl acetate. The new compound may then be converted to the respective acid dichloride by reacting with a chlorinating reagent, which is a further object of the present invention, followed by the amidation with 2-amino-1,3-propanediol and acetate hydrolysis.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: September 16, 2014
    Assignee: Hovione Inter Limited
    Inventors: Jose Manuel Galindro, Ana Cristina Cruz, João José Bandarra, William Heggie
  • Manufacture of a Triiodinated Contrast Agent
    Publication number: 20140155648
    Abstract: A new compound, (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid, of formula II (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid. Said new compound is of use for the production of triiodinated contrast agent, especially lopamidol, with low content of acetyl and hydroxyacetyl analogs. The new compound may be formed from 5-amino-2,4,6-triiodoisophtalic acid by acylating with (S)-1-chloro-1-oxopropan-2-yl acetate. The new compound may then be converted to the respective acid dichloride by reacting with a chlorinating reagent, which is a further object of the present invention, followed by the amidation with 2-amino-1,3-propanediol and acetate hydrolysis.
    Type: Application
    Filed: February 2, 2012
    Publication date: June 5, 2014
    Applicant: HOVIONE INTER LIMITED
    Inventors: Jose Manuel Galindro, Ana Cristina Cruz, João José Bandarra, William Heggie