Patents by Inventor Jose Manuel Martinez Costas

Jose Manuel Martinez Costas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protein muNS that can form inclusions in the endoplasmic reticulum, methods for the use thereof and uses of same
    Patent number: 11174485
    Abstract: The invention relates to a polynucleotide encoding a polypeptide based on the minimum region of the Orthoreovirus muNS protein that can form inclusions in the endoplasmic reticulum, and to said polypeptide. The invention also relates to a purification method and a method for detecting interaction between two polypeptides based on the capacity of some regions of the Orthoreovirus muNS protein to incorporate themselves into the inclusions, together with a peptide of interest.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: November 16, 2021
    Assignee: UNIVERSID ADE DE SANTIAGO DE COMPOSTELA
    Inventors: José Manuel Martínez Costas, Natalia Barreiro Piñeiro, Francisco Javier Benavente Martínez
  • METHOD FOR PRODUCING GLUCOSE-6-PHOSPHATASE 2 PROTEIN
    Publication number: 20210139869
    Abstract: The invention relates to a fusion protein comprising glucose-6-phosphatase 2 protein and a polypeptide derived from avian or mammalian Orthoreovirus muNS protein, as well as a method for producing said protein, and to the use of said protein to treat type 1 diabetes.
    Type: Application
    Filed: April 9, 2019
    Publication date: May 13, 2021
    Inventors: José Manuel MARTÍNEZ COSTAS, Rubén VARELA CALVIÑO, Natalia BARREIRO PIÑEIRO, Francisco Javier BENAVENTE MARTÍNEZ
  • Applications of the protein muNS and the derivates thereof
    Patent number: 10059745
    Abstract: The invention is based on the identification of the minimum region of the avian Orthoreovirus muNS protein which is capable of forming inclusions as well as on the identification of specific regions of the muNS protein showing capacity to associate with the inclusions formed by muNS. The identification of said regions allows developing methods for purifying recombinant polypeptides as well as methods for detecting the interaction between two polypeptides of interest.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: August 28, 2018
    Assignee: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Alberto Brandariz Nunez, Rebeca Menaya Vargas, Francisco Javier Benavente Martinez, Jose Manuel Martinez Costas
  • PROTEIN MUNS THAT CAN FORM INCLUSIONS IN THE ENDOPLASMIC RETICULUM, METHODS FOR THE USE THEREOF AND USES OF SAME
    Publication number: 20170298365
    Abstract: The invention relates to a polynucleotide encoding a polypeptide based on the minimum region of the Orthoreovirus muNS protein that can form inclusions in the endoplasmic reticulum, and to said polypeptide. The invention also relates to a purification method and a method for detecting interaction between two polypeptides based on the capacity of some regions of the Orthoreovirus muNS protein to incorporate themselves into the inclusions, together with a peptide of interest.
    Type: Application
    Filed: September 1, 2015
    Publication date: October 19, 2017
    Inventors: José Manuel Martínez Costas, Natalia Barreiro Piñeiro, Francisco Javier Benavente Martínez
  • APPLICATIONS OF THE PROTEIN MUNS AND THE DERIVATES THEREOF
    Publication number: 20120301493
    Abstract: The invention is based on the identification of the minimum region of the avian Orthoreovirus muNS protein which is capable of forming inclusions as well as on the identification of specific regions of the muNS protein showing capacity to associate with the inclusions formed by muNS. The identification of said regions allows developing methods for purifying recombinant polypeptides as well as methods for detecting the interaction between two polypeptides of interest.
    Type: Application
    Filed: February 11, 2011
    Publication date: November 29, 2012
    Inventors: Alberto Brandariz Nunez, Rebeca Menaya Vargas, Francisco Javier Benavente Martinez, Jose Manuel Martinez Costas