Patents by Inventor Jose Manuel Mejia Oneto

Jose Manuel Mejia Oneto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Trans-Cyclooctene Bioorthogonal Agents and Uses in Cancer and Immunotherapy
    Publication number: 20230256109
    Abstract: Trans-cyclooctene conjugates of immunomodulatory agents may be used for bioorthogonal delivery to a targeted location in a subject. The compositions and methods have applications in the treatment of cancer, tumor growths, and immunotherapy.
    Type: Application
    Filed: August 6, 2021
    Publication date: August 17, 2023
    Inventors: Jose Manuel Mejia Oneto, Nathan A. Yee, Sangeetha Srinivasan, Michael Zakharian, Jesse M. McFarland
  • TRANS-CYCLOOCTENE BIOORTHOGONAL AGENTS AND USES IN CANCER AND IMMUNOTHERAPY
    Publication number: 20220259254
    Abstract: Trans-cyclooctene conjugates of therapeutic agents may be used for bioorthogonal delivery to a targeted location in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.
    Type: Application
    Filed: July 6, 2020
    Publication date: August 18, 2022
    Inventors: Jose Manuel Mejia Oneto, Nathan A. Yee, Sangeetha Srinivasan, Michael Zakharian
  • BIOORTHOGONAL COMPOSITIONS
    Publication number: 20220168426
    Abstract: Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.
    Type: Application
    Filed: December 14, 2021
    Publication date: June 2, 2022
    Inventors: Jose Manuel MEJIA ONETO, Nathan YEE, Maksim ROYZEN, Sangeetha SRINIVASAN, Ethan MILLER
  • Bioorthogonal compositions
    Patent number: 11253600
    Abstract: Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: February 22, 2022
    Assignees: TAMBO, INC., THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Jose Manuel Mejia Oneto, Nathan Yee, Maksim Royzen, Sangeetha Srinivasan, Ethan Miller
  • BIOORTHOGONAL COMPOSITIONS
    Publication number: 20210128733
    Abstract: Cyclooctene conjugates of therapeutic or diagnostic agents have improved aqueous solubility and can release the agents upon contact with a tetrazine-containing biomaterial. The cyclooctene conjugates provide site-selective delivery of agents at the location of the tetrazine-containing biomaterial in a subject. The compositions and methods have applications in the treatment of various diseases or conditions including cancer, tumor growths, and bacterial infections.
    Type: Application
    Filed: April 6, 2018
    Publication date: May 6, 2021
    Inventors: Jose Manuel MEJIA ONETO, Nathan YEE, Maksim ROYZEN, Sangeetha SRINIVASAN, Ethan MILLER
  • Chemical structures for localized delivery of therapeutic agents
    Patent number: 10953098
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: March 23, 2021
    Assignees: The Regents of the University of California, Alchemical Research Holdings, LLC
    Inventors: Jose Manuel Mejia Oneto, Ziyad F. Al-Rashid
  • TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20210060188
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Application
    Filed: September 11, 2020
    Publication date: March 4, 2021
    Inventors: Jose Manuel Mejia Oneto, Maksim Royzen
  • TCO conjugates and methods for delivery of therapeutic agents
    Patent number: 10806807
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: October 20, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEWYORK
    Inventors: Jose Manuel Mejia Oneto, Maksim Royzen
  • TCO conjugates and methods for delivery of therapeutic agents
    Patent number: 10342882
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: July 9, 2019
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Jose Manuel Mejia Oneto, Maksim Royzen
  • CHEMICAL STRUCTURES FOR LOCALIZED DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20190111140
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Application
    Filed: October 2, 2018
    Publication date: April 18, 2019
    Applicants: The Regents of the University of California, ALCHEMICAL RESEARCH HOLDINGS, LLC
    Inventors: Jose Manuel MEJIA ONETO, Ziyad F. AL-RASHID
  • TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20190111163
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Application
    Filed: October 10, 2018
    Publication date: April 18, 2019
    Inventors: Jose Manuel MEJIA ONETO, Maksim ROYZEN
  • Chemical structures for localized delivery of therapeutic agents
    Patent number: 10130711
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: November 20, 2018
    Assignees: The Regents of the University of California, Alchemical Research Holdings, LLC
    Inventors: Jose Manuel Mejia Oneto, Ziyad F. Al-Rashid
  • TCO conjugates and methods for delivery of therapeutic agents
    Patent number: 10130723
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: November 20, 2018
    Assignees: The Regents of the University of California, The Research Foundation for the State University of New York
    Inventors: Jose Manuel Mejia Oneto, Maksim Royzen
  • TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20170095580
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Application
    Filed: December 16, 2016
    Publication date: April 6, 2017
    Applicants: The Regents of the University of California, The Research Foundation for the State University of New York
    Inventors: Jose Manuel Mejia Oneto, Maksim Royzen
  • TCO CONJUGATES AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20170087258
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Application
    Filed: September 14, 2016
    Publication date: March 30, 2017
    Inventors: Jose Manuel Mejia Oneto, Maksim Royzen
  • CHEMICAL STRUCTURES FOR LOCALIZED DELIVERY OF THERAPEUTIC AGENTS
    Publication number: 20160120987
    Abstract: The present invention provides a method for selective delivery of a therapeutic or diagnostic agent to a targeted organ or tissue by implanting a biocompatible solid support in the patient being linked to a first binding agent, and administering a second binding agent to the patient linked to the therapeutic or diagnostic agent, such that the therapeutic or diagnostic agent accumulates at the targeted organ or tissue.
    Type: Application
    Filed: June 18, 2014
    Publication date: May 5, 2016
    Inventors: Jose Manuel Mejia Oneto, Ziyad F. Al-Rashid