Abstract: The portable office-in-a-box allows a user to readily transport and set up an office and workstation at any location. The portable office-in-a-box comprises a substantially rectangular shaped box comprising a base, a lid configured to engage with the base to define the rectangular shaped box, multiple panels, one or more enclosures, multiple mounting fixtures, office equipment and office supplies. The multiple panels are disposed on an inner surface of the base, and inner surface of the lid. A first set of the panels secure one or more office items, and a second set of the panels define one or more enclosures to secure other office items. Multiple drawers slidably engage with the base for providing storage of office equipment and office supplies. Multiple mounting accessories are disposed on the inner surface of the lid for securing office equipment and accessories.