Abstract: A sensor comprising a field-effect transistor of a semiconducting material in two-dimensional nanosheets having an interfacial nanoarchitecture comprising a recognition element, a structural element and a polymeric coating, a gate electrode of the transistor being coplanar with a drain electrode and a source electrode of the transistor; a system using the sensor and methods of preparation and use thereof. The disclosed sensor has increased stability and an interfacial nanoarchitecture suitable for the immobilization of a broad number of recognition elements without loss of their biological activity.

Abstract: An electronic device and method for continuous noninvasive blood pressure monitoring in a subject having an electronic device capable of receiving, storing and processing data from an arterial pulse waveform sensor. The electronic device detects key landmarks on the arterial pulse waveform allowing the calculation of pulse rate and left ventricular ejection time (LVET). Based on experimentally determined regression equations between rate-corrected LVET and systolic diastolic and pulse blood pressures, prevailing beat-to-beat blood pressure values are calculated. The only input required for continuous blood pressure monitoring is an arterial pulse waveform, detected in the present invention by a single sensor device, for example a photoplethysmography pulse detector. An electronic device suitable for performing this noninvasive method is further provided.