Abstract: The invention relates to a composition and related methods for enhancing the immune response and/or decreasing the size or growth rate of a tumor volume in a subject. The composition comprises a recombinant MVA encoding IL-12 and, optionally, a Tumor Associated Antigen (“TAA”). In some embodiments, the MVA also encodes 4-1BBL and/or a second MVA encoding 4-1BBL is coadministered to the subject. In some embodiments of the invention, methods comprise injecting these MVAs intratumorally. In some embodiments, the recombinant MVAs are injected intraperitoneally to stimulate an immune response to peritoneal tumors.

Abstract: Embodiments of the present disclosure are directed towards coated fertilizer granule compositions that include three polyurethane layers and two wax layers.

Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding a tumor-associated antigen and an administration of an antibody to a cancer patient.

Abstract: Methods for treating a producing wellbore of a subterranean reservoir include obtaining a side stream flow of a produced fluid from a production tube of the wellbore at a location above the surface of the earth; providing an eluting contact of the side stream flow of produced fluid with a treatment material to form a side stream flow of treated produced fluid; and directing the side stream flow of treated produced fluid into the wellbore at a point below the surface of the earth. Apparatuses suitable for carrying out the methods include an elution device fluidly connected to a side stream of produced fluid flowing above the surface of the earth and situated to direct the side stream toward the elution device to provide an eluting contact of the produced fluid with a treatment material disposed in the elution device, then direct the treated produced fluid into the wellbore.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: Disclosed is a method and system to combine virtual reality techniques with a consumer's real-world space to identify ways to reduce energy consumption and reduce their attendant carbon footprint through an immersive energy assessment. An object is identified that is related to the consumption of energy in the consumer's real-world space, the system is able to present energy information that is specific to that object. This is in contrast to generic information such as an energy star rating. The specific energy information in one example is derived from data from many sources, including smart electric meters, smart appliances, smart home equipment, Internet of thing equipment, smart thermostats, smart speakers, and in-line watt meters.

Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding CD40L and an administration of an antagonist or agonist of an immune checkpoint molecule.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: Illustrative embodiments provide a method and system for communicating air traffic control information. An audio signal comprising voice activity is received. Air traffic control information in the voice activity is identified using an artificial intelligence algorithm. A text transcript of the air traffic control information is generated and displayed on a confirmation display. Voice activity in the audio signal may be detected by identifying portions of the audio signal that comprise speech based on a comparison between the power spectrum of the audio signal and the power spectrum of noise and forming speech segments comprising the portions of the audio signal that comprise speech.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding a tumor-associated antigen and an administration of an antibody to a cancer patient.

Abstract: The invention relates to a recombinant Modified Vaccinia Virus Ankara (MVA) encoding a spike (S) protein or a part thereof, such as a receptor-binding domain (RBD), and additional antigenic sequences derived from other proteins of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 19 (COVID-19).

Abstract: The invention relates to a composition and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The composition comprises a recombinant MVA encoding a Tumor Associated Antigen (“TAA”) as well as 4-1BBL and/or CD40L and can be administered to a subject in any suitable manner, including by intravenous and/or intratumoral administration.

Abstract: Described herein are compounds of Formula I and pharmaceutically acceptable salt thereof, stereoisomers, tautomers as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: The invention relates to a recombinant Modified Vaccinia Virus Ankara (MVA) expressing a TAA and the costimulatory molecule 4-1BBL for use in (i) the prevention of recurrence of a solid tumor, wherein the recombinant MVA is intratumorally administered to the solid tumor, or (ii) the treatment, prevention and/or prevention of recurrence of a tumor, wherein the recombinant MVA is intratumorally administered to another solid tumor.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: The invention relates to a pharmaceutical combination and related methods for reducing tumor volume and/or increasing the survival of a cancer patient. The combination comprises an intravenous administration of a recombinant MVA encoding a tumor-associated antigen and an administration of an antibody to a cancer patient.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: A computer-readable media, system, and method for providing role-based access management to channels within a group-based communication system. Role-based access management allows for a plurality of roles to be established and for users to be associated with these roles. Roles may be associated with sets of permissions allowing users assigned to the respective role to perform various actions within the group-based communication system. The group-based communication system may include preset, system roles with predetermined permissions and custom, user-defined roles may be created by administrators within the group-based communication system.

Abstract: A floor includes structural floor joist that includes a flange and tabs punched out of the flange (forming holes in the flange). Flooring material of the floor that extrudes through at least one of the holes is bonded to some of the tabs and the flange of the structural floor joist, forming a bonded composite assembly of the structural floor joist and the forming material, that has a centroid that is located in or near the forming material, placing some of the forming material in compression and placing at least 90% of the structural floor joist in tension.