Abstract: This method provides a method for reducing HIV-1 viral load in an HIV-1-infected human subject which comprises administering to the subject at a predefined interval effective HIV-1 viral load-reducing doses of (a) a humanized antibody designated PRO 140, or of (b) an anti-CCR5 receptor monoclonal antibody. This invention also provides a method for inhibiting in a human subject the onset or progression of an HIV-1-associated disorder, the inhibition of which is effected by inhibiting fusion of HIV-1 to CCR5+CD4+ target cells in the subject. This invention also provides a method for treating a subject infected with HIV-1 comprising administering to the subject (a) a monoclonal antibody which (i) binds to a CCR5 receptor on the surface of the subject's CD4+ cells and (ii) inhibits fusion of HIV-1 to the subject's CCR5+CD4+ cells, and (b) a non-antibody CCR5 receptor antagonist, in amounts effective to treat the subject.

Abstract: An axial-flow pump combined with an electric motor coaxially arranged therearound. The rotor (1) and stator (2) are common to both the electric motor and the pump. The rotor comprises a central tubular portion (11) defining a central channel (14) with a wall (15) provided with blades (16). The blades preferable do not extend as far as the channel axis (3) so that they define a central free area therealong. The outer portion of the rotor (1) has pairs of permanent magnets (24, 25) with stator coils (9) therebetween. The coils are actuated and deactuated by an electronic switching device (28) controlled by sensors (36, 37) for sensing markings on the rotor. The length of the rotor is smaller than its outer diameter. Said pump may be used to pump liquids or gases and drive vehicles, particularly submarines.

Abstract: The skate includes an under-frame (3) equipped with two or several rollers aligned one behind the other in a common median plane. Each roller (4, 5) has a shape of a narrow-bobbin, with two circular flanges provided with bands and a central hollowed hub, fixed inside a ball-bearing. This bearing is put in an orifice of a central plate (24) of the under-frame, this plate holding also a front buffer-stop (6) and a back buffer-stop (7). An instrument absorbing the shocks in the radial direction is intercalated between the bearing and the plate (24). Preferably, the under-frame (3) of the skate is equipped with a support for a leg (1) which is articulated in relation to a transverse axis (Y) at the level of the ankle. A braking mechanism of the rollers (4, 5) can be fixed on the central plate (24) of the under-frame. Thanks to the special shape of the rollers, bearings and the under-frame are lightened.