Abstract: A sample is separated by a first separator into constituent analytes over a time parameter. The constituent analytes are analysed by a mass spectrometer, which provides intensity measurements against mass-to-charge ratio for each constituent analyte. A relationship of the measured intensity at a mass-to-charge ratio over the time parameter for each constituent analyte defines a respective peak. A peak quality factor may be determined for each of the peaks and/or a common peak position in respect of the time parameter may be determined for at least some of the peaks. A specific range for a time parameter to be used for quantifying the substance may be based on the peak quality factor (or factors). Alternatively, a subset of the peaks may be selected for quantification of the substance, based on the determined peak quality factors and/or the determined common peak position.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: A boat trailer axle rinsing system including a pipe assembly and a tank assembly is disclosed herein. The pipe assembly includes a flush pipe and a nozzle pipe, the nozzle pipe is connected to the flush pipe by a valve, the nozzle pipe includes a plurality of nozzles to rinse an underside of a boat. The tank assembly includes a tank and a dial. The tank stores a desalination chemical. The dial controls the ratio of dilution of the desalination chemical with water provided to the tank by a water hose or by a pump. The tank has an output having a manifold connected therein. The manifold is connected to the flush pipe to provide the desalination chemical to the nozzle pipe to rinse a boat. The pipe assembly is mounted to a trailer axle. The tank assembly is mounted to a front portion of the trailer axle.

Abstract: The recited invention is a method of treating patients having macular edema secondary to branch renal vein occlusion. The patients are treated with a liposomal nanoparticle formulation comprising thermodynamically stable liposomes and a steroid such as triamcinolone acetonide. The formulation is a topical ophthalmic formulation administered topically to treat the posterior segment disease.

Abstract: A multi-compartment sprayer with a main body and an outer casing and which houses a plurality of conduits intended for containing fluids to be sprayed independently. It includes movable equipment having a rotary movement assembly which rotates about a guide shaft of the sprayer and allows selecting the product to be sprayed and has an unlocking movement assembly configured to move axially in the direction of the guide shaft. Likewise, the sprayer includes fixed equipment with a fixed casing inside which the movement assemblies are arranged and with an actuating trigger and a locking button to allow/prevent the change of nozzles for product selection.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: Systems and methods are disclosed for analyzing a sample using overlapping precursor isolation windows. A mass analyzer of a tandem mass spectrometer is instructed to select and fragment at least two overlapping precursor isolation windows across a precursor ion mass range of a sample using a processor. The tandem mass spectrometer includes a mass analyzer that allows overlapping precursor isolation windows across the mass range of the sample.

Abstract: The invention relates to a support (1) comprising a U-shaped enveloping body (1) having an elastic structure formed by a front limb (1a), a rear limb (1b) and a concave bottom (1c), where the U-shaped enveloping body (1) defines an inner space (9) where the external device (3) of the catheter fits tightly. The support (1) also has at least one extension (4) which projects from one of the limbs of the U-shaped enveloping body (1), where said limb and the extension (4) face each other, forming a clip device (5) for attaching the support to the patient's garment, the clip device (5) being formed outside the inner space (9) of the U-shaped enveloping body (1).

Abstract: Systems and methods are disclosed for detecting compounds in a sample using a tandem mass spectrometer. A sample comprising a plurality of detectable compounds that have been separated in time over a time interval is introduced into a tandem mass spectrometer. A sample product ion spectra is obtained. The presence of one or more known compounds of interest in the sample product ion spectra is determined. A compound is identified as present in the sample if the score associated with said compound meets a threshold value set as indicative of the likely presence of the compound in the sample.

Abstract: Systems and methods are disclosed for identifying detectable compounds of a sample. Sample product ion spectra are received for each mass selection window of precursor mass selection windows for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving a known product ion spectrum from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectrum, generating product ion traces in time for the retrieved sample product ion spectra, calculating a score for the product ion traces and the retrieved sample product ion spectra that represents how well the retrieved sample product ion spectra and the known product ion spectrum match, and confirming the identity of a precursor ion using the score.

Abstract: Systems and methods are disclosed for quantitating detectable compounds of a sample. Sample product ion spectra are received for each mass selection window for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving the known product ion spectra from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectra, generating product ion traces in time for the sample product ion spectra for the known product ion spectra, calculating a score for the product ion traces and product ion spectra that represents how well known product ions and sample product ions match, and calculating a quantitative value for the known compound from the product ion traces when the score exceeds a threshold value.

Abstract: Systems and methods are disclosed for quantitating detectable compounds of a sample. Sample product ion spectra are received for each mass selection window for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving the known product ion spectra from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectra, generating product ion traces in time for the sample product ion spectra for the known product ion spectra, calculating a score for the product ion traces and product ion spectra that represents how well known product ions and sample product ions match, and calculating a quantitative value for the known compound from the product ion traces when the score exceeds a threshold value.

Abstract: Systems and methods are disclosed for identifying detectable compounds of a sample. Sample product ion spectra are received for each mass selection window of precursor mass selection windows for each time step. The received sample product ion spectra are searched for the presence of known compounds of interest with known product ion spectra by retrieving a known product ion spectrum from a library, retrieving the sample product ion spectra corresponding to the precursor mass selection window expected to contain a precursor ion corresponding to the known product ion spectrum, generating product ion traces in time for the retrieved sample product ion spectra, calculating a score for the product ion traces and the retrieved sample product ion spectra that represents how well the retrieved sample product ion spectra and the known product ion spectrum match, and confirming the identity of a precursor ion using the score.

Abstract: Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.

Abstract: Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.

Abstract: A hat insert device for maintaining a hat in a desired condition is provided. The hat has an inner flap along an opening of the hat. The hat insert device comprises a flat, planar insert having a first side, a second side substantially opposite the first side, a top edge, a bottom edge substantially opposite the top edge, a first edge between the top edge and the bottom edge, and a second edge substantially opposite the first edge. A retaining mechanism is formed in either the top edge of the insert or the bottom edge of the insert for maintaining the insert in a desired position. Upon positioning the insert inside the inner flap at the front of the hat, the insert provides support, stiffness, and structure in the hat.

Abstract: Systems and methods are used to store an electronic record of all product ion spectra of all detectable compounds of a sample. A plurality of product ion scans are performed on a tandem mass spectrometer one or more times in a single sample analysis across a mass range using a plurality of mass selection windows. All sample product ion spectra of all detectable compounds for each mass selection window are produced. All sample product ion spectra for each mass selection window are received from the tandem mass spectrometer using a processor. All sample product ion spectra for each mass selection window are stored as an electronic record of all detectable compounds of the sample using the processor. The electronic record is used to characterize compounds known at the time the electronic record is stored or to characterize compounds that became known after the electronic record was stored.