Abstract: Two forms of N-[[[2-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]ethyl]amino] methylene]-4-bromo-benzenesulfonamidehave been identified. A process for the preparation of thereof and the use thereof are described.

Abstract: The process consists of reacting (-)trans-N-p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]-piperid ine acetate with 2-chloro- or 2-bromo-4'-fluoroacetophenone. The resulting compound can be isolated as a pharmaceutically acceptable addition salt by reaction with the corresponding acid.

Abstract: A method and apparatus for automatically transferring a predetermined quantity of a sterile liquid to a vial containing a dry medicament for hydrating the medicament and then transferring the hydrated medicament to a container. To hydrate the medicament, a needle is positioned through a vial septum of the vial and an artificial sensor senses when the needle has been positioned through the vial septum and actuates a pump to transfer a predetermined quantity of sterile liquid into the vial. The needle is then removed from the vial septum and the vial is shaken to mix the liquid and medicament. To transfer the hydrated medicament to a container, another needle is positioned through the vial septum. An artificial sensor senses when the needle has been positioned through the vial septum and actuates the pump to transfer the hydrated medicament to the container.

Abstract: Two polymorphs of 1-?2,4-dichloro-.beta.-?(7-chloro-benzo?b!thien-3-yl)methoxy!phenetyl!imid azole mononitrate have been identified. A process for the preparation thereof and composition are described.

Abstract: A method of automatically producing a plurality of prefilled, sterile delivery devices with a desired quantity of fluid. The sterile delivery devices each include a hollow barrel with a dispensing nozzle at one end and an open opposite end. A piston plunger is positioned within the open end and is slidable in sealing engagement with the barrel to retain a fluid therein. A tip is secured to the dispensing nozzle. A plurality of the sterile delivery devices are automatically fed along a predetermined path. Tips are then removed from the dispensing nozzles of the sterile delivery devices. The hollow barrels of the sterile delivery devices are then filled through the dispensing nozzles with a desired is quantity of fluid. The dispensing nozzles of the sterile delivery devices are then closed and sealed after the filling step to provide sealed sterile delivery devices with sterile fluid contents.

Abstract: A method and apparatus for automatically transferring a predetermined quantity of a sterile liquid to a vial containing a dry medicament for hydrating the medicament and then transferring the hydrated medicament to a container. To hydrate the medicament, a needle is positioned through a vial septum of the vial and an artificial sensor senses when the needle has been positioned through the vial septum and actuates a pump to transfer a predetermined quantity of sterile liquid into the vial. The needle is then removed from the vial septum and the vial is shaken to mix the liquid and medicament. To transfer the hydrated medicament to a container, another needle is positioned through the vial septum. An artificial sensor senses when the needle has been positioned through the vial septum and actuates the pump to transfer the hydrated medicament to the container.

Abstract: An arrangement and method for identifying mechanical damage in a mechanism having a multiplicity of different sections which generate different actual sounds due to damage in each section, uses a sound sample storage for storing a sound sample of each of the different actual sounds. A selector is connected to the sound sample storage for selecting one of the sound samples corresponding to a section which is suspected of being damaged. A sound generator generates the sound sample selected by the selector, to make the sound sample audible, for use in comparing the sound sample to the actual sound of the section which is suspected of being damaged, for identifying the section which is damaged if the actual sound is similar to the audible sound sample.

Abstract: Polymorph B of (1-diphenylmethyl)-4-?3-(2-phenyl-1,3-dioxolan-2-yl)propyl!piperazine have been identified. A process for its preparation and its use are described.

Abstract: The present invention relates to new 5H-thiazolo?3,2-a!pyrimidin -5-one derivatives having the formula (I): ##STR1## wherein Ar is phenyl optionally substituted by one or two groups selected from halogen, alkyl having from 1 to 4 carbon atoms, methylendioxy, alkoxy having from 1 to 4 carbon atoms, and trifluoromethyl; and R is a group selected from (a) or (b): ##STR2## as well as their pharmaceutically acceptable addition salts, which are useful in the treatment of psychosis, schizophrenia and anxiety. This invention also discloses methods and intermediates for their preparation and pharmaceutical compositions containing them.

Abstract: The present invention relates to 4-(6-fluoro-1,2-benzisoxazolyl)-1-piperidinyl-propoxy-chromen-4-one derivatives having the formula (I): ##STR1## wherein R is hydrogen or alkyl having 1 to 4 carbon atoms optionally substituted by hydroxyl, as well as their pharmaceutically acceptable addition salts, which are useful in the treatment of psychosis, schizophrenia and anxiety.

Abstract: The invention relates to new N-benzoylmethyl-piperidines of the general formula (I): ##STR1## wherein X is a halogen atom, as well as their pharmaceutically acceptable addition salts. The compounds are potentially useful to treat depressions.

Abstract: The present invention relates to new chromene compounds of the general formula (I): ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, alkyl having from 1 to 4 carbon atoms, halogen, trifluoromethyl, optionally substituted phenyl, or hydroxymethyl, as well as their pharmaceutically acceptable addition salts.These compounds are useful in the treatment of psychosis and schizophrenia.

Abstract: 4-Benzylpiperidine derivatives of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein X is hydrogen or fluorine and R is hydrogen, or a group selected from p-fluorobenzoyl, .alpha.-hydroxy-p-fluorobenzyl, p-fluorophenoxy, bis(p-fluorophenyl)methyl and 8-azaspiro[4,5]decane-7,9-dione-8-yl-methyl, with the proviso that X and R may not be simultaneously hydrogen and p-fluorobenzoyl respectively.Such compounds are useful as sigma-receptor ligands.

Abstract: A light bulb mounting arrangement has at least one continuous grooved indentation about the base portion and an adapter to fit the device to present day threaded sockets. The bulb is retained in a substantially tubular socket which is in a close fitting or telescopic relation with the base. The retaining mechanism has at least two spring-loaded fingers having nodes thereon with cross-sectional profiles similar to and matable with those of the grooved indentions. Optionally, the adapter upon installation is captive within the existing conventional socket.

Abstract: An electric light bulb and socket system is described. The system includes a bulb with a base having a substantially cylindrical wall and a single groove extending thereinto and thereabout and also includes a socket base with an open cavity therein and retaining springs for retaining the bulb. The retaining springs are mounted within the wall of the socket base, except for the lugs of the retaining springs which extend into the socket base cavity. The lugs of the retaining springs are dimensioned to, upon the insertion of the bulb into the receptacle, protrude into the groove and to seat therewithin. As the lugs are equally spaced about the groove, the lugs exert a balanced spring pressure on the bulb to retain the bulb in the socket. With this system, the insertion of the bulb into the socket is by axial movement without orientation and without rotation thereof.

Abstract: The 1H-imidazole derivative compound of formula I: ##STR1## and its nontoxic addition salts, particularly the nitrate addition salt, are more effective as antimycotic agents and are unexpectedly safer than the corresponding prior art compounds, especially the compound in which the sulfur atom of the benzothiophene ring of the above compound is replaced by an oxygen atom. Pharmaceutical compositions containing an effective amount of the compound of formula I, e.g. 1 to 5% by weight, in a pharmaceutical carrier are safer, more effective, and, in some cases, more reliable with fewer side effects than currently used antimycotic preparations.

Abstract: Derivatives of piperazine having the general formula ##STR1## wherein R.sub.1 is benzhydryl or cinnamyl and R.sub.2 is selected from the group consisting of ##STR2## --(CH.sub.2).sub.3 --R.sub.8, --CH.sub.2 NHR.sub.9, --CH.sub.2 NH.sub.2 and --COR.sub.10 ; wherein R.sub.3 is hydrogen, chloromethyl, (4-benzhydryl-1-piperazinyl) methyl, 4-morpholinylmethyl or 1-piperidinylmethyl, R.sub.4 is hydrogen, chloromethyl or carbethoxy, R.sub.5 and R.sub.6 taken together are an oxygen atom or the radical --O--(CH.sub.2).sub.2 --O--, R.sub.7 is methyl, phenyl or 2-thienyl, R.sub.8 is 4-morpholinyl, 1-piperidinyl or 4-benzhydryl-1-piperazinyl, R.sub.9 is 2-oxo-1- (pyrrolidinyl) acetyl, 2-hydroxybenzoyl or 4-sulfamoylbenzoyl, R.sub.10 is 2-oxo-1-(pyrrolidinyl)methyl or 4-sulfamoylphenyl and X is oxygen or NH; as well as methods for making the same and their use in a pharmaceutical composition is proposed. The compounds have cardiovascular properties and increasing effects on cerebral flow.