Abstract: The disclosed apparatus, systems and methods relate to a smart minimally invasive glaucoma surgery (Smart-MIGS) device configured for passive and active flow. Various implementations are defined by a combination device that integrates intraocular pressure (IOP) monitoring, drug delivery and a drainage function for pressure control in the body or bodily region of a subject.

Abstract: A platform for hermetic heterogeneous integration of passive and active electronic components is provided herein. The platform can include a substrate that provides a hermetic electrical interconnection between integrated circuits and passive devices, such as resistors, capacitors, and inductors. Such substrates can be formed of a dielectric, such as a ceramic, and include electrical interconnects and can further include one or more passive devices. The substrate can include one or more cavities, at least a primary cavity dimensioned to receive an active device and one or more secondary cavities can be included for secondary connector pads for interfacing with the active and passive devices and which can be separately hermetically sealed. The substrate can include a multi-coil inductor defined within alternating layers of the substrate within sidewalls that surround the primary cavity to minimize size of the device package while optimizing the size of the coil.