Abstract: The present invention relates to compounds that are useful for modulating hepatic cholesterol metabolism in an animal. The invention includes methods of making and using the compounds of the invention. The invention further provides methods of treating, preventing and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in an animal, such as a human, comprising administering compounds of the invention, or pharmaceutically acceptable salts or solvates thereof, to the animal.

Abstract: The present invention relates to compounds that are useful for modulating hepatic cholesterol metabolism in an animal. The invention includes methods of making and using the compounds of the invention. The invention further provides methods of treating, preventing and/or alleviating a cholesterol related disorder, a cardiovascular disease and/or liver disease in an animal, such as a human, comprising administering compounds of the invention, or pharmaceutically acceptable salts or solvates thereof, to the animal.

Abstract: A pair of safety sunglass, particularly for use when arc welding, includes auto darkening lenses having suitable characteristics for providing high intensity light protection during welding procedures. The sunglasses have a tight fitting frame conforming to an individual's face curvature. When an arc is struck, or another high intensity light source is present, the lenses instantly and automatically darken to protect the individual's eyes from damage. Each lens includes a plurality of layers for prohibiting the high intensity direct light rays from passing therethrough. A feature and benefit of such eyewear is that welding operations may be performed in confined spaces where a conventional welding face shield can not fit. When the welding is completed, the eyeglasses would quickly return to their sun tinted state allowing them to be used as a conventional pair of sunglasses.

Abstract: The retractable pet guard has a screen or net extending retractably from a housing which is temporarily secured to either the latch edge of a door or to the latch side of a door frame. The extension edge of the net secures removably to the opposite member of the door assembly, extending across the doorway when the door is opened. The device extends from the floor upwardly to about the level of the doorknob and latch, thereby preventing the escape of pets and/or small children while still permitting a transaction(s) to take place through the open doorway above the screen or net. A stop may be provided to prevent door closure due to the pull of the retraction mechanism, and/or a retraction stop may be provided to prevent retraction as desired. The device may also be installed in a window opening to serve as a window screen, if desired.

Abstract: Novel indolyl-2-phenyl bisamidines are described which are DNA methyltransferase inhibiting agents, and pharmaceutical compositions containing them are used as antiproliferative agents for treating a disease, especially a neoplastic disease, characterized by abnormally rapid proliferation of tissue involved in said disease; said indolyl-2-phenyl bisamidines comprising a and a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen or (C1-C3)alkyl; R3, R4, R5, R8, R9, and R10 are hydrogen or (C1-C3)alkyl, or R3 and R4 may be taken together, or R8 and R9 may be taken together with the nitrogen atoms to which they are attached, to form an imidazolinyl group; R14 is —H; —NHC(═O)(CH2)mR20; —(CH2)mR20; —CH(CH3)R20; —(CH2)m(C6H3)—R17; —(CH2)m(C6H3)—R20; —(CH2)m(heterocyclyl)—R17; —(CH2)m(heterocyclyl)—R20; —CH2CH═CHR20; —(CH2)mC(═O)NH—CHR20R21; or —(CH2)mC(═O)NH—CH2&m

Abstract: The present invention describes the incorporation of liposomal gene constructs directly into a wound to further improve wound repair, or into wound coverage and/or closure materials to enhance the functionality of the material. The present invention further describes the use of human fetal membranes (e.g., amnion) enhanced with the liposomal gene therapy as a wound coverage material in full-thickness wound repair. The enhanced fetal membranes or enhanced cadaver skin have advantages over currently used materials lacking the liposomal gene construct and are an efficient and safe approach to improve clinical outcome in patients with burn injuries.

Abstract: The present invention describes the incorporation of liposomal gene constructs directly into a wound to further improve wound repair, or into wound coverage and/or closure materials to enhance the functionality of the material. The present invention further describes the use of human fetal membranes (e.g., amnion) enhanced with the liposomal gene therapy as a wound coverage material in full-thickness wound repair. The enhanced fetal membranes or enhanced cadaver skin have advantages over currently used materials lacking the liposomal gene construct and are an efficient and safe approach to improve clinical outcome in patients with burn injuries.

Abstract: Known bisamidine compounds are newly discovered to possess DNA methyltransferase inhibiting properties, making them useful for preparing pharmaceutical compositions useful as antiproliferative agents for treating a neoplastic or a non-neoplastic disease characterized by abnormally rapid proliferation of tissue involved in said disease; wherein said bisamidines comprise a compound of Formula (5.0.0): and a pharmaceutically acceptable salt thereof, wherein: —X is —C(R34)—; or —N—; —R23, R24, R28 and R29 are each independently —H; or —CH2— where R23 and R24 and R28 and R29 are taken together with the nitrogen atoms to which they are attached, to form an imidazolinyl group; and —R34 is —H; or —CH3. A preferred species of Formula (5.0.0) is the following: 2-(4-Carbamimidoyl-phenyl)-1H-indole-6-carboxamidine.

Abstract: A tool for adjustably spacing components during an alignment procedure. The inventive device includes a spreader plate pivotally mounted to an engaging yoke. A handle assembly is coupled to the yoke to facilitate manual placement of the yoke and spreader plate between two components to be adjusted. An adjustment assembly is rotatably coupled to the handle assembly for selectively pivoting the spreader plate relative to the yoke to separate the components to a desired spacing.

Abstract: A safety valve cap providing an elongated inner chamber with an internally screw-threaded open lower end for threaded engagement on the extended end of a conventional valve stem associated with a vehicle tire, for example. A check valve is movably positioned in the inner chamber between a compression spring and a depressor plate. When the safety valve cap is threaded onto the valve stem, the depressor plate actuates the valve stem check valve releasing compressed air into a first portion of the inner chamber until the air pressure therein is balanced with the tire pressure.